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Hubei Jusheng Technology Co., Ltd.,High quality LCZ696 LCZ696 Supplier 936623-90-4//file1.lookchem.com/cas/reactions/2021/05/26/22138143.png
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High quality LCZ696 LCZ696 Supplier 936623-90-4 CAS NO.936623-90-4

FOB Price:
USD 2.00-2.00 /Kilogram Get Latest Price
Min.Order Quantity:
10 Kilogram
Purity:
98%
Port:
Wuhan/ Shanghai / Guangzhou / Tianjin Port
Payment Terms:
T/T,MoneyGram

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Product Details

Keywords

  • LCZ696
  • High quality LCZ696
  • cas no:936623-90-4

Quick Details

  • ProName: High quality LCZ696 LCZ696 Supplier 9...
  • CasNo: 936623-90-4
  • Molecular Formula: 2(C24H29N5O3).2(C24H29NO5).5(H2O).6Na
  • Appearance: White or almost white crystalline powd...
  • Application: Aceclofenac is an anti-inflammatory an...
  • DeliveryTime: According to the order quantity and or...
  • PackAge: Foil Bag or as Required
  • Port: Wuhan/ Shanghai / Guangzhou / Tianjin ...
  • ProductionCapacity: 50 Metric Ton/Day
  • Purity: 98%
  • Storage: Storaged in dry, ventilate and cool pl...
  • Transportation: EMS、TNT、DHL、UPS、FEDEX、SF、Wuhan Port、Sh...
  • LimitNum: 10 Kilogram
  • Moisture Content: 0.001
  • Impurity: 0.001

Superiority

1.high quality and competetive price

1)for prulifloxacin exported we can offer coa certificate and official invoice.
2)we are manufacturer with own lab and factory, can provide high quality products with factory price.
3)products purity is test by our quality department strictly before sending, and you can also ask the third testing organization come and inspect, such as (sgs/ cti/ its), only after your confirmation will we send it out to you.

2.fast and safe delivery:
1)products can be sent out one or four weeks after payment. tracking number available, fixed service person are 7x24h for you to contact.
2) secure and discreet shipment. various transportation methods for your choice, like dhl/ups/tnt/fedex/sf-express.
3)customs pass and satisfied rate ¡ý99%.
4)for hot sale products we have stock in there for transferring.

3 we have clients throughout the world:
1) professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) market feedback and goods feedback will be appreciated, meeting customers' requirement is our responsibility.
3) high quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

Details

product name: lcz696
synonyms: 3-(1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-3'-methyl-2'-(pentanoyl(2'-(tetrazol-5-ylate)biphenyl-4'-ylmethyl)amino)butyrate;valsartan/sacubitril;lcz696 intermediate;n-(1-oxopentyl)-n-[[2'-(2h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-l-valine, compd. with α-ethyl (αr,γs)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl[1,1'-biphenyl]-4-pentanoate, sodium salt, hydrate (2);valsartan-sacubitril(lcz696);entresto;lzc696;[(c24h29n5o3).(c24h29no5).2.5(h2o).3na]
cas: 936623-90-4
mf:

2(c24h29n5o3).2(c24h29no5).5(h2o).6na

lcz696 is a dual-acting angiotensin-receptor enkephalinase inhibitor that has a unique mechanism that is thought to reduce the strain of failing hearts. lcz696 can enhance the body's natural defense against heart failure, as well as increase the level of natriuretic peptides and other endogenous vasoactive peptides, and inhibit the renin-angiotensin-aldosterone system (raas). lcz696 has combined with novartis's hypertension medication (diovan, generic name: valsartan) and the experimental drug ahu-377. ahu377 blocks the mechanism of the two peptides responsible for lowering blood pressure. diovan improves vasodilatation and stimulates the body to excrete sodium and water.
the safety threshold of cardiovascular drugs is extremely high, and lcz696 even shows a higher safety than conventional drugs. previously, novartis vigorously develop the cardiovascular drug— serelaxi, while because of security issues, both the fda and the european union did not grant this drug. this is undoubtedly a heavy blow to novartis. however, the success of lcz696 will pay back novartis a big era in the cardiovascular field.。
in august 2014, novartis announced significant results as a landmark of paradigm-hf trial. lcz696 was significantly superior to the ace inhibitor enalapril at several key end points, including a significant reduction in cardiovascular death risk or heart failure hospitalization rate. these latest analyzes were first disclosed at the american heart association scientific conference in 2014 and published in circulation at the same time.
on november 30, 2014, the european medicines agency (emp) committee for medicinal products for human use (chmp) has granted lcz696 an accelerated eligibility, so it became the first cardiovascular drug to qualify for accelerated evaluation in the history of eu drug regulation. prior to this, the eu's accelerated assessment of qualifications was never granted to the cardiovascular field.
lcz696 is an experimental drug developed for the treatment of patients with heart failure with reduced ejection fraction (hfref). accreditation of accelerated evaluation by chmp means that the review time of lcz696 will be shortened by 60 days in official eu. novartis is expected to submit lcz696 application approval (maa) in the european union at the beginning of 2015. the maa submission will be based on data from the landmark phase iii paradigm-hf study, which is the largest study of heart failure patients conducted in the history. the data show that the efficacy and safety of lcz696 is beyond the clinical standard drug enalapril (enalapril), including significantly reduced cardiovascular death or heart failure hospitalization risk
the industry believes that lcz696's outstanding performance, make it became one of the most important progress over the past 10 years in the field of cardiology. at the same time, in the next few years, there will be no drug to compete with the lcz696 in the cardiovascular field. some analysts predict that the lcz696 sales peaked at $ 8 billion; while deutsche bank analysts expect the drug to peak at $ 6 billion, given lcz696's superior performance in reducing cardiovascular risk. although the data are slightly different, but there is no doubt that, lcz696 will become a super star for novartis. in addition to bring rolling financial resources, it will lead the cardiovascular treatment step into a new era.
in february 2015, novartis pharma test drug lcz696 was given priority review by the us food and drug administration (fda) for the treatment of heart failure with reduced ejection fraction (hfref). novartis added that the drug's overall review time will be reduced by 8 months, the fda may make its approval decision in august.
novartis said its listing application in us was based on a 3-phase paradigm-hf study, which showed a significant reduction in cardiovascular mortality and heart failure hospitalization compared with the ace inhibitor enalapril.

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