USD $1.00-1.00 / Kilogram
USD $9.00-99.00 / Kilogram
USD $1.00-1.00 / Kilogram
USD $2.00-10.00 / Kilogram
USD $1.00-1.00 / Kilogram
USD $2.00-10.00 / Kilogram
USD $2.00-10.00 / Kilogram
USD $2.00-10.00 / Kilogram
USD $2.00-10.00 / Kilogram
product name: | isoquinoline |
synonyms: | benzo(c)pyridine;fema 2978;leucoline;isochinolin;isoquinoline;2-benzazine;2-azanaphthalene;2-benzanine |
cas: | 119-65-3 |
mf: | c9h7n |
mw: | 129.16 |
einecs: | 204-341-8 |
product categories: | pyridine;quinoline&isoquinoline;building blocks;heterocyclic building blocks;isoquinolines;building blocks;chemical synthesis;heterocyclic building blocks |
mol file: | 119-65-3.mol |
isoquinoline chemical properties |
melting point | 26-28 °c(lit.) |
boiling point | 242-243 °c(lit.) |
density | 1.099 g/ml at 25 °c(lit.) |
fema | 2978 |
refractive index |
n |
fp | 225 °f |
storage temp. | 2-8°c |
water solubility | practically insoluble |
merck | 14,5222 |
brn | 107549 |
cas database reference | 119-65-3(cas database reference) |
nist chemistry reference | isoquinoline(119-65-3) |
epa substance registry system | isoquinoline(119-65-3) |
safety information |
hazard codes | t |
risk statements | 22-24-38-52/53-36/38-21/22-45 |
safety statements | 36/37-45-36/37/39-61-53 |
ridadr | un 2811 6.1/pg 3 |
wgk germany | 2 |
rtecs | nw6825000 |
hazardclass | 6.1 |
packinggroup | ii |
msds information |
provider | language |
---|---|
sigmaaldrich | english |
acros | english |
alfa | english |
isoquinoline usage and synthesis |
chemical properties | colorless flaky crystal or liquid, similar fragrance to bitter almonds and chervil, sweet taste, melting point 23℃,boiling point 243℃, soluble in ethanol and non-volatile oil, diluted inorganic acid and most organic solvents, slightly soluble in water. |
usage |
|
usage limitation | fema(mg/kg): soft drinks 0.25,, cold drinks 0.25, sweets1.0; bakery products 0.004-1.0, moderate use (fda§172.515,2000). |
preparation |
crude quinoline containing 83% quinoline, 15% isoquinoline and 2% methyl quinoline can be used as the raw material for the production of isoquinoline. however, the distillation section from 237.5-239.5℃ and 243-246℃ is generally collected and used as the raw material for the extraction of isoquinoline. 13-28% of 2-methyl quinoline and 3.9% quinoline can be separated from this distillation section in the form of hydrochloride salt. the isoquinoline fraction reacted with 98% sulfuric acid at 35℃ in alcohol solution to produce isoquinoline sulfonate. isoquinoline sulfonate crystallizes faster than its homologues in the cooling process. after filtration, recrystallization was carried out with 85% ethanol, and then decomposed with 20% ammonia water. the generated oil layer was firstly washed with water, and then rectified to collect the fraction at242-243℃to obtain isoquinoline with purity greater than 95% it is separated by repeated freezing the coal tar with the boiling rangeat 238~250℃. |
content analysis | determined by gas chromatography and liquid chromatography and the chromatographic test conditions are the same as α-allyl ionone (03411). |
category | flammable liquid |
toxicity grade | middle toxic |
toxicity | gras(fema) |
acute toxicity | oral – rat ld50: 360mg/kg |
stimulus data | skin-rabbit 10 mg/24h mild; eye-rabbit 250 μg severe. |
flammability hazard characteristics | flammable in case of fire, high temperature and oxidants, combustion produces toxic nitrogen oxide smog. |
storage | completely packed, handle with care; ventilated warehouse, away from open flame, high temperature, separated from strong acids. |
fire extinguishing agent | foam, carbon dioxide, dry powder, dry sand, water spray. |
chemical properties | light brown low meltling solid |