LY2874455 CAS NO.1254473-64-7

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Min.Order Quantity:: 100 Gram

Purity:: 98%

Port:: shang hai

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Product Details

Keywords

LY2874455
LY 2874455;(R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol;4-[(1E)-2-[5-[(1R)-1-(3,5-Dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]-1H-pyraz
1254473-64-7

Quick Details

ProName: LY2874455
CasNo: 1254473-64-7
Molecular Formula: C21H19Cl2N5O2
Appearance: White crystal
Application: CAS：1254473-64-7；LY 2874455;(R,E)-2-(4...
DeliveryTime: 3 months
PackAge: 100g,500g,1kg,25kg
Port: shang hai
ProductionCapacity: 100 Metric Ton/Week
Purity: 98%
Storage: Dry seal
Transportation: shipping
LimitNum: 100 Gram

Superiority

we are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research.

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our research team of scientists consists of western-trained ph.d.s with experience and capabilities in drug r&d methodologies and medicinal chemistry.

Details

ly2874455

生物活性体外研究体内研究

中文名称:	ly2874455
中文同义词:	4-[(1e)-2-[5-[(1r)-1-(3,5-二氯-4-吡啶基)乙氧基]-1h-吲唑-3-基]乙烯基]-1h-吡唑-1-乙醇;ly 2874455,4-[(1e)-2-[5-[(1r)-1-(3,5-二氯-4-吡啶基)乙氧基]-1h-吲唑-3-基]乙烯基]-1h-吡唑-1-乙醇
英文名称:	ly 2874455
英文同义词:	ly 2874455;(r,e)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1h-indazol-3-yl)vinyl)-1h-pyrazol-1-yl)ethanol;4-[(1e)-2-[5-[(1r)-1-(3,5-dichloro-4-pyridinyl)ethoxy]-1h-indazol-3-yl]ethenyl]-1h-pyrazole-1-ethanol;ly2874455/ly-2874455;4-[(1e)-2-[5-[(1r)-1-(3,5-dichloro-4-pyridinyl)ethoxy]-1h-indazol-3-yl]ethenyl]-1h-pyrazole-1-ethanol ly2874455
cas号:	1254473-64-7
分子式:	c21h19cl2n5o2
分子量:	444.31386
einecs号:
相关类别:	蛋白酪氨酸激酶;小分子抑制剂;inhibitors;小分子抑制剂，天然产物
mol文件:	1254473-64-7.mol

ly2874455 性质

密度

1.44

ly2874455 用途与合成方法

生物活性	ly2874455是一个泛fgfr的抑制剂，对fgfr1，fgfr2, fgfr3, 和fgfr4的ic50值分别为2.8 nm, 2.6 nm, 6.4 nm,以及6 nm。并且也能抑制vegfr2的活性，ic50为7 nm。phase 1。
体外研究	在rt-112细胞，huvecs，kato-iii 细胞，和snu-16细胞，ly2874455抑制fgf/fgfr介导的信号活性。ly2874455在kms-11，opm-2，snu-16 和kato-iii细胞中表现出fgfr依赖性抗增殖作用。
体内研究	在小鼠心脏组织中，ly2874455对fgf诱导的erk磷酸化表现出有效的抑制作用， ted50 和 ted90 值分别为1.3 和 3.2 mg/kg。在负荷rt-112，opm-2 (dsmz)，snu-16，或nci-h460异种移植物的小鼠体内，ly2874455 (3 mg/kg p.o.)剂量依赖性抑制肿瘤生长。