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HENAN SUNLAKE ENTERPRISE CORPORATIONLeflunomide//www.lookchem.com/300w/\2010-5\1dd39a4b-7e9b-4f57-a7cc-4772ec967a1d.jpg
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Leflunomide CAS NO.75706-12-6

Min.Order Quantity:
1 Kilogram
Purity:
98%
Port:
TIANJIN/SHANGHAI
Payment Terms:
L/C,D/P,T/T,Western Union

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Product Details

Keywords

  • 5-methyl-n-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamid
  • HWA 486
  • 5-methylisoxazole-4-carboxylicacid(4-trifluoromethyl)anilide

Quick Details

  • ProName: Leflunomide
  • CasNo: 75706-12-6
  • Molecular Formula: C12H9F3N2O2
  • Appearance: Off White Crystalline Solid
  • Application: vasodilator
  • DeliveryTime: within 7-10days after receiving paymen...
  • PackAge: as required
  • Port: TIANJIN/SHANGHAI
  • ProductionCapacity: 200 Kilogram/Month
  • Purity: 98%
  • Storage: 2-8°C
  • Transportation: by sea/ by express
  • LimitNum: 1 Kilogram
  • 57260-71-6: 57260-71-6

Superiority

Henan Sunlake Enterprise Corporation

Our Advantages

1, Any inquiry about chemicals will be welome and replied within 24 hours;

2, Competitive price;

3, Good quality is guaranteed;

4, Fast and safe delivery;

5, Full experience in manufacture and international trade;

6, Perfect and professional service.

Details

Product information

Leflunomide Basic information
Product Name: Leflunomide
Synonyms: LEFLUNOMIDE;HWA 486;ALPHA,ALPHA,ALPHA-TRIFLUORO-5-METHYL-4-ISOXAZOLECARBOXY-P-TOLUIDIDE;5-METHYLISOXAZOLE-4-(4-TRIFLUOROMETHYLCARBOXANILIDE);5-METHYL-N-[4-(TRIFLUOROMETHYL)PHENYL]-4-ISOXAZOLECARBOXAMIDE;N-(4-TRIFLUOROMETHYLPHENYL)-5-METHYLISOXAZOL-4-CARBOXAMIDE;5-methylisoxazole-4-carboxylicacid(4-trifluoromethyl)anilide;5-methyl-n-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamid
CAS: 75706-12-6
MF: C12H9F3N2O2
MW: 270.21
EINECS:
Product Categories: Active Pharmaceutical Ingredients;API;Osteoarthritis and Rheumatoid Arthritis;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Cytokine signaling;Aromatics;Heterocycles;An immunosuppressive agent;CARDENE;Other APIs
Mol File: 75706-12-6.mol
Leflunomide Structure
Leflunomide Chemical Properties
mp 163-168°C
storage temp. 2-8°C
CAS DataBase Reference 75706-12-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38
Safety Statements 26-36
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS NY2354200
Hazardous Substances Data 75706-12-6(Hazardous Substances Data)
MSDS Information
Provider Language
Leflunomide English
SigmaAldrich English
Leflunomide Usage And Synthesis
Chemical Properties Off White Crystalline Solid
Usage An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutical
Usage vasodilator
Usage anti-Altzheimer therapeutic
Biological Activity Immunosuppressant agent. In vitro the active metabolite A77 1726 (RS-61980) inhibits dihydroorotate dehydrogenase (K i = 2.7 μ M) and de novo pyrimidine synthesis in T-cells; blocks lymphocyte cell cycle progression and proliferation. A77 1726 also inhibits anti-CD3/CD28-induced cytokine production in PBMC cells (IC 50 = 21-27 μ g/ml). In vivo reduces inflammation in several animal models of autoimmune disease, arthritis, asthma and graft rejection.
Company information

Henan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .

Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.

We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.

We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.

We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate.

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