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Hubei XinRunde Chemical Co., LtdLegal Gefitinib Manuafcturer CAS 184475-35-2 Pharmaceutical Cancer Treating Raw Material//www.lookchem.com/300w/\2011-9\7ed242bc-fed6-44fa-bc23-1d27bc928b5b.gif
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Legal Gefitinib Manuafcturer CAS 184475-35-2 Pharmaceutical Cancer Treating Raw Material CAS NO.184475-35-2

Min.Order Quantity:
10 Gram
Purity:
99%
Port:
Wuhan
Payment Terms:
T/T,Western Union,MoneyGram

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Product Details

Keywords

  • 99% Gefitinib
  • Pharmaceutical Raw Materials
  • API Manufacturer

Quick Details

  • ProName: Legal Gefitinib Manuafcturer CAS 18447...
  • CasNo: 184475-35-2
  • Molecular Formula: C22H24ClFN4O3
  • Appearance: White Powder
  • Application: It Can Be Used As Pharmaceutical Inte...
  • DeliveryTime: 2-4 days after confirming your payment...
  • PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
  • Port: Wuhan
  • ProductionCapacity: 10000 Metric Ton/Month
  • Purity: 99%
  • Storage: Store in sealed containers at cool & d...
  • Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
  • LimitNum: 10 Gram

Superiority

Advantages:

Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.


2. Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.


3. Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.


4. Warm after-sale service Any of your question would be solved for the first as soon as possible.

Details

Sarms Steroids Gefitinib CAS 184475-35-2 for Anticancer Ingredients

Technical Data:

M. Wt: 446.9
Formula: C22H24ClFN4O3
Storage: Store at RT
Purity: ≥98% (HPLC)
CAS Number: 184475-35-2
PubChem ID: 123631
InChI Key: XGALLCVXEZPNRQ-UHFFFAOYSA-N
Solubility: DMSO (44.69), ethanol (4.47)

COA:

Product name
Gefitinib
CAS No.
184475-35-2
Outer Packing
1KG
Production date
May,05,2016
Shelf life
May.04,2019
Standard adopted

house standard
Items of analysis Specification Results


Appearance


White to off-white powder


off-White powder


Identifcation


HPLC(RT)


Complies


Loss on drying


≤ 0.5%


0.13%


Residue on ignition


≤0.,1%


0.1%


Max Single Impurity


≤ 0.10 %


0.09%


Total Impurity


≤.1.0%


0.24%


Purity(HPLC)


≥99%


99.76%
Conclusion Qualified


Mechanism of action:



Gefitinib is the first selective inhibitor of epidermal growth factor receptor's (EGFR) tyrosine kinase domain. Thus gefitinib is an EGFR inhibitor. The target protein (EGFR) is a member of a family of receptors (ErbB) which includes Her1(EGFR), Her2(erb-B2), Her3(erb-B3) and Her4 (Erb-B4). EGFR is overexpressed in the cells of certain types of human carcinomas - for example in lung and breast cancers. This leads to inappropriate activation of the anti-apoptotic Ras signalling cascade, eventually leading to uncontrolled cell proliferation. Research on gefitinib-sensitive non-small cell lung cancers has shown that a mutation in the EGFR tyrosine kinase domain is responsible for activating anti-apoptotic pathways.These mutations tend to confer increased sensitivity to tyrosine kinase inhibitors such as gefitinib and erlotinib. Of the types of non-small cell lung cancer histologies, adenocarcinoma is the type that most often harbors these mutations. These mutations are more commonly seen in Asians, women, and non-smokers (who also tend to more often have adenocarcinoma).

Gefitinib inhibits EGFR tyrosine kinase by binding to the adenosine triphosphate (ATP)-binding site of the enzyme.Thus the function of the EGFR tyrosine kinase in activating the anti-apoptotic Ras signal transduction cascade is inhibited, and malignant cells are inhibited.


How to use Gefitinib Tablet:



Take gefitinib by mouth once daily, with or without food, or as directed.

Medications which reduce or completely block stomach acid (e.g., proton pump inhibitors/PPIs, H2 blockers, antacids) may decrease the absorption of gefitinib. This could decrease the effectiveness of gefitinib. Consult your doctor or pharmacist if you are taking any of these medications.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time each day...

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