MONOCROTALINE CAS NO.315-22-0

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Min.Order Quantity:: 1 Gram

Purity:: 99% min

Port:: China main port

Payment Terms:: L/C,T/T,

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Product Details

Keywords

MONOCROTALINE
high purity MONOCROTALINE
factory supply MONOCROTALINE

Quick Details

ProName: MONOCROTALINE
CasNo: 315-22-0
Molecular Formula: C16H23NO6
Appearance: White to light tan powder
Application: Pharmaceutical intermediates
DeliveryTime: in stock
PackAge: as you requested
Port: China main port
ProductionCapacity: 10 Kilogram/Day
Purity: 99% min
Storage: Room temperature
Transportation: by courier
LimitNum: 1 Gram
Transportation: by courier

Superiority

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1.noble metal catalysts (pt.pd...)

2.organic phosphine ligands (tert-butyl-phosphine.cyclohexyl-phosphine...)

3.oled intermediates (fluorene,carbazole,boric acid...)

4.customs synthesis

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Details

description references

product name:	monocrotaline
synonyms:	monocrotalin;monocrotaline;crotalin;crotaline;(13-alpha,14-alpha)-14,19-dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dio;(13-alpha,14-alpha)-14,19-dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione;(2,3,4-gh)pyrrolizine-2,6(3h)-dione,(4,5,8,10,12,13,13a,13b-octahydro-4,5-dihy;(2,3,4-gh)pyrrolizine-2,6(3h)-dione,(4,5,8,10,12,13,13a,13b-octahydro-4,5-dihydroxy-3,4,5-trimethyl-2h-(1,6)dioxacycloundecino-
cas:	315-22-0
mf:	c16h23no6
mw:	325.36
einecs:	2017-001-1
product categories:	miscellaneous natural products;amines;heterocycles;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from chinese medicinal herbs (tcm).;standardized herbal extract;inhibitors
mol file:	315-22-0.mol

monocrotaline chemical properties

melting point	204 °c (dec.)(lit.)
alpha	-54.8o (c=5 in chloroform)
storage temp.	2-8°c
merck	13,6274

safety information

hazard codes	t
risk statements	25-40-35
safety statements	36/37/39-45
ridadr	un 1544 6.1/pg 3
wgk germany	3
rtecs	qb3140000
hazardclass	6.1(b)
packinggroup	iii

msds information

provider	language
sigmaaldrich	english
acros	english

monocrotaline usage and synthesis

description	monocrotaline (mct) is a toxic 11-membered macrocyclic pyrrolizidine alkaloid (pa) derived from the seeds of the crotalaria spectabilis plant. it poisons livestock and humans through the ingestion of contaminated grains and other foods. pyrrolizidine alkaloid is activated by cytochrome p450 to the reactive pyrrole metabolite dehydromonocrotaline (mctp) in the liver. the alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. monocrotaline is produced for research use. it is used in rat model to investigate human pulmonary hypertension as it offers technical simplicity, reproducibility, and low cost compared with other models of pulmonary hypertension.
references	[1] jose g. gomez-arroyo, laszlo farkas, aysar a. alhussaini, daniela farkas, donatas kraskauskas, norbert f. voelkel, harm j. bogaard (2012) the monocrotaline model of pulmonary hypertension in perspective, am j physio lung cell mol phyisol, 302, l363-l369 [2] #
chemical properties	white to light tan powder
uses	a toxic pyrrolizidine alkaloid isolated from crotalaria spp. it is used for inducing pulmonary diseases in rats.
uses	antineoplastic, insect sterilant