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Shanghai Minstar Chemical Co., LtdNaphazoline hydrochloride 550-99-2 Large in supply//file1.lookchem.com/cas/reactions/2021/06/03/3716843.png
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Naphazoline hydrochloride 550-99-2 Large in supply CAS NO.550-99-2

Min.Order Quantity:
1 Kilogram
Purity:
99.00%
Port:
Shanghai
Payment Terms:
T/T,MoneyGram,Other

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Product Details

Keywords

  • Naphazoline hydrochloride supplier
  • 550-99-2
  • Naphazoline HCL

Quick Details

  • ProName: Naphazoline hydrochloride 550-99-2 Lar...
  • CasNo: 550-99-2
  • Molecular Formula: C14H15ClN2
  • Appearance: white crystalline powder
  • Application: adrenergic blocker
  • DeliveryTime: in stock
  • PackAge: drums
  • Port: Shanghai
  • ProductionCapacity: 100 Kilogram/Month
  • Purity: 99.00%
  • Storage: dry and cool
  • Transportation: air, courier and sea
  • LimitNum: 1 Kilogram

Superiority

product name: naphazoline hydrochloride
synonyms: naphconforte;naphthasoliumchloride;niazol;privinehydrochloride;prizolehydrochloride;rhinantin;rhinoperd;sanorin-spofa
cas: 550-99-2
mf: c14h15cln2
mw: 246.74
einecs: 208-989-2
product categories: adrenoceptor;normodyne;pharmaceutical intermediates
mol file: 550-99-2.mol
naphazoline hydrochloride structure
naphazoline hydrochloride chemical properties
melting point 254-260 °c
water solubility 170 g/l (20 ºc)
sensitive hygroscopic
merck 14,6368
brn 3716843
cas database reference 550-99-2(cas database reference)
safety information
hazard codes t,xn
risk statements 25-23/24/25-20/21/22
safety statements 45-36/37/39-24/25
ridadr un 2811 6.1/pg 2
wgk germany 3
rtecs nj4375000
hazardclass 6.1
packinggroup iii
hazardous substances data 550-99-2(hazardous substances data)

Details


pharmacological effects naphazoline hydrochloride, is commonly used as a vasoconstrictor in the hospital's otorhinolaryngology and ophthalmology ,it is a adrenomimetic drug ,it has a strong effect on contraction of blood vessels and blood pressure elevation,it has inhibition effect on the central nervous system,by contraction of local vascular, it can play an anti-inflammatory and analgesic role in the local inflammatory lesions , and can eliminate congestion due to fatigue or other reasons. clinically it is used for the treatment of colds, acute and chronic rhinitis, allergic conjunctivitis, allergic and inflammatory nasal congestion embolism. local long-term use can lead to blood flow reduction in medication area, which causes resistance decreasing , and results in superinfection. it can not be taken orally. dropping excess liquid or high concentrations can cause poisoning. care should be taken, especially in children. infants, hypertension, hyperthyroidism patients should take with caution, atrophic rhinitis patients are banned. the interval time of dropping , is preferably not less than 4 to 6 hours.
the above information is edited by the chemicalbook of tian ye.
chemical properties white crystalline powder. melting point 255-260 ℃. 40 grams of the product can be dissolved in 100 ml of water . it is soluble in alcohol, slightly soluble in chloroform, insoluble in ether and benzene. odorless, bitter taste.
uses this product is a vasoconstrictor. rat subcutaneous injection is ld50 385 mg/kg.
production method by the α-naphthalene acetic acid and ethylene diamine condensation, cyclization ,2-(1-naphthylmethyl) imidazoline (c14h14n2, [835-31-4]) is made , then after salifying, naphazoline hydrochloride is derived . the α-acetic acid and ethylene diamine are added to the reaction pot, stir and heat to 120 ℃, react after 1 hour, then heat to 130 ℃, react for 1 hour. ethylenediamine and water are distilled ,and after vacuum distillation, collect 180-240 ℃ (1.33-4 kpa) distillate, obtain 2-(1-naphthylmethyl) imidazoline. it is dissolved in a mixture of acetone and ethanol, and at 10-12℃ inlet hydrogen chloride gas to become into a salt, naphazoline hydrochloride crystals is generated .
chemical properties white crystalline powder
uses adrenergic blocker
uses antihistamine

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