Neratinib CAS NO.698387-09-6

Min.Order Quantity:: 100 Metric Ton

Purity:: 98%min

Port:: Qingdao,China

Payment Terms:: L/C,T/T,MoneyGram,Other

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698387-09-6
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ProName: Neratinib
CasNo: 698387-09-6
Molecular Formula: C30H29ClN6O3
Appearance: white powder
Application: Used for research and industrial manuf...
DeliveryTime: Within7-10 days after receipt of your ...
PackAge: As customer request
Port: Qingdao,China
ProductionCapacity: 100kg/Month Metric Ton/Day
Purity: 98%min
Storage: Store in a cool,dry place and keep awa...
Transportation: Common products:Sea/Air/Courier Dange...
LimitNum: 100 Metric Ton

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lorcaserin(856681-05-5)is an orally administered agent and a selective 5-ht2c receptor agonist for the treatment of obesity. it had been approved for marketing in us by fda on 27 june in 2012. in clinical studies, lorcaserin has demonstrated efficacy in obese and overweight populations by promoting weight loss and improving metabolic parameters, and it is well tolerated.

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proname: neratinib 698387-09-6 c30h29cln6o3
casno: 698387-09-6
molecular formula: c30h29cln6o3
appearance: detailed in specifcations
application: aripiprazole intermediate functional...
deliverytime: within 5days
package: as needed
port: china main port
productioncapacity: 500 metric ton/month
purity: 99%
storage: keep in dry and cool condition
transportation: by air or sea
limitnum: 1 kilogram
mf: c13h21o3ps

details

neratinib basic information

synthesis pathways side effect

product name:	neratinib
synonyms:	(2e)-n-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide;neratinib;(e)-n-[4-[3-chloro-4-[(2-pyridinyl)methoxy]anilino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide;(2e)-n-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide;n-(4-(3-chloro-4-(2-pyridinylmethoxy)anilino)-3-cyano-7-ethoxy-6-quinolyl)-4-(dimethylamino)-2-butenamide;unii-jjh94r3pwb;neratinib(hki-272);(2e)-n-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
cas:	698387-09-6
mf:	c30h29cln6o3
mw:	557.04266
einecs:
product categories:	antineoplastic;anti-cancer & immunity;inhibitors
mol file:	698387-09-6.mol

neratinib chemical properties

density

1.33

safety information

msds information

neratinib usage and synthesis

new anticancer drug

neratinib developed by us wyeth company is an irreversible epidermal growth factor receptor(egfr) inhibitor. it is a multiple target point of small molecule tyrosine kinase inhibitors to her 2 and her1 after lapatinib, and is an irreversible erbb receptor tyrosine kinase inhibitor. neratinib could selectively inhibit her-1 and her-2 of egfr family(ic50 was 92 nmol/l and 59 nmol/l, respectively). clinical research showed that neratinib exerted significant therapeutic effect on non-small cell lung cancer, colon cancer, and breast cancer.
the phaseⅱclinical trial indicated that neratinib showed good efficacy and tolerance to her-2 positive patients with advanced breast cancer who had been received or not trastuzumab treatment.
the phase ⅲ breast cancer clinical trial was complete in september 2014. the data indicated that the efficacy of neratinib was better than roche's herceptin in treatment of her-2 positive early breast cancer.
the above information is edited by the chemicalbook of liu yujie.

synthesis pathways

3-chloro-4- (pyridin-2-yl-methoxy) - aniline (2) and n- (4- chloro-3-cyano-7-ethoxy-quinolin-6-yl) - acetamide (3) are used as raw material to prepare n- [4- [3- chloro-4- (pyridin-2-yl-methoxy) anilino] -3-cyano-7-ethoxy-quinolin-6-yl] acetamide (4) by nucleophilic substitution. deprotection of 4 was under the effect of hydrochloric acid, then was precipitated the free base in methanol