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Offer CAS.NO: 21829-25-4 CAS NO.21829-25-4

FOB Price:
USD 1.00-1.00 /Kilogram Get Latest Price
Min.Order Quantity:
1 Kilogram
Purity:
99%
Port:
China main ports
Payment Terms:
L/C,T/T,MoneyGram,Other

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Product Details

Keywords

  • 21829-25-4
  • 21829-25-4
  • 21829-25-4

Quick Details

  • ProName: Offer CAS.NO: 21829-25-4
  • CasNo: 21829-25-4
  • Molecular Formula: C17H18N2O6
  • Appearance: Yellow Crystalline Solid
  • Application: 21829-25-4
  • DeliveryTime: Promopt .
  • PackAge: 1g;5g;10g;25g;50g;100g;500g;1KG;5KG,25...
  • Port: China main ports
  • ProductionCapacity: 100 Kilogram/Month
  • Purity: 99%
  • Storage: 21829-25-4
  • Transportation: by air /by sea /by courier
  • LimitNum: 1 Kilogram
  • Valid Period: 6 month
  • Application: Multipurpose intermediate
  • Certification: ISO/9001 Certificate

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2. material safety data sheet (msds)

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nifedipine basic information
pharmacological effects chemical properties application production methods category toxicity grading acute toxicity flammability and hazard characteristics storage characteristics extinguishing agent
product name: nifedipine
synonyms: 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylicaciddime;3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester;4-(2’-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethy;5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-dim;adalat cc;bay1040;corinfar;dimethyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate
cas: 21829-25-4
mf: c17h18n2o6
mw: 346.34
einecs: 244-598-3
product categories: pharmaceutical;active pharmaceutical ingredients;dihydropyridine class chemicals;functional materials;photopolymerization initiators;intermediates & fine chemicals;pharmaceuticals;calcium channel;ion channels;dihydropyridine;pharmaceutical intermediate;isotopically labeled pharmaceutical reference standard;capoten;cardiovascular apis;cardiovascular drugs
mol file: 21829-25-4.mol
nifedipine structure
nifedipine chemical properties
mp 171-175 °c
storage temp. 2-8°c
solubility dmso: soluble
form powder
color yellow
water solubility <0.1 g/100 ml at 19.5 ºc
merck 6528
cas database reference 21829-25-4(cas database reference)
nist chemistry reference nifedipine(21829-25-4)
epa substance registry system 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-( 2-nitrophenyl)-, dimethyl ester(21829-25-4)
safety information
hazard codes xn,xi
risk statements 22-36/37/38
safety statements 26-36
wgk germany 1
rtecs us7975000
hazardclass irritant
msds information
provider language
nifedipine english
sigmaaldrich english
acros english
nifedipine usage and synthesis
pharmacological effects nifedipine is a kind of dihydropyridine calcium antagonists, it can inhibit the ca2 + uptake of cardiac and vascular smooth muscles, and it can expand the coronary artery , increase coronary blood flow,and improve myocardial ischemic tolerance, at the same time, it can expand peripheral arteries and reduce peripheral vascular resistance,and relieve coronary artery spasm, and increase coronary blood flow, improve myocardial ischemia,in order to decrease the blood pressure. small doses do not affect blood pressure, when expanding coronary artery ,it is a better anti-angina drug .it is used for the prevention and treatment of angina pectoris,with no adverse effects on respiratory function, its efficacy is best particularly for angina pectoris coronary spasm and obstructive airway disease with angina , its efficacy is superior to β-blockers.it is also applied to all types of high blood pressure, including severe and resistant hypertension. treatment of refractory congestive heart failure may be taking this long. it is also used for the treatment of primary pulmonary hypertension, diffuse esophageal spasm and bronchial asthma, duodenal ulcers, urinary tract obstruction, exercise-induced asthma, achalasia.
nifedipine has a certain selectivity on vascular smooth muscles , the direct negative inotropic effect and denaturation effect on the heart are weak, systemic administration of it does not cause the heart rate slowing down ,on the contrary, the heart rate performances reflected increase.
the above information is edited by the chemicalbook of tian ye.
chemical properties yellow crystals. melting point 172-174 ℃. soluble in acetone, chloroform, ethyl acetate, dissolved in hot methanol, insoluble in water. it easily deteriorates in case of light.
application long-term coronary vasodilators. this product can increase coronary blood flow, reducing myocardial oxygen consumption.it is used for acute and chronic coronary insufficiency,especially the angina and myocardial infarction.
production methods o-nitrobenzaldehyde, methyl acetoacetate, methanol, ammonia are refluxed together , then froze , crystallize,after filtration, nifedipine crude is obtained . the crude product is recrystallized through methanol .then the product is derived , yield rate is 50%.
category toxic substances
toxicity grading highly toxic
acute toxicity oral - rat ld50: 1022 mg / kg; oral - mouse ld50: 310 mg / kg.
flammability and hazard characteristics combustion produces toxic fumes of nitrogen oxides; medicinal side effects: low blood pressure, cardiac disease, local blood flow disease, high blood sugar, psychosis.
storage characteristics ventilated , low-temperature, drying; and it is kept separately from food raw materials warehouse.
extinguishing agent dry powder, foam, sand, carbon dioxide, water spray.
chemical properties yellow crystalline solid
usage used as an antihypertensive and antianginal. a dihydorpyridine calcium channel blocker
usage for the management of vasospastic angina, chronic stable angina, hypertension, and raynaud's phenomenon. may be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents).
general description odorless yellow crystals or powder. tasteless.
air & water reactions aqueous solutions are very sensitive to light. . insoluble in water.
reactivity profile nifedipine is sensitive to light.
fire hazard flash point data for nifedipine are not available; however, nifedipine is probably combustible.
biological activity l-type calcium channel blocker.

hennan sunlake enterprise corporation is located in henan province , the central plain of china , which enjoys favorable geogeaphical position and convenient transportion, the com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
sunlake is a professional manufacturer engaged in producing and selling chemicals,including organic & inorganic chemicals , pigments & dyestuffs , water treatment chemicals , food & feed additives and others . these products have been being well exported to europe , southeast asia , the middle east , africa , south america and some other countries and areas.

Details

nifedipine basic information
pharmacological effects chemical properties application production methods category toxicity grading acute toxicity flammability and hazard characteristics storage characteristics extinguishing agent
product name: nifedipine
synonyms: 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylicaciddime;3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester;4-(2’-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethy;5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-dim;adalat cc;bay1040;corinfar;dimethyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate
cas: 21829-25-4
mf: c17h18n2o6
mw: 346.34
einecs: 244-598-3
product categories: pharmaceutical;active pharmaceutical ingredients;dihydropyridine class chemicals;functional materials;photopolymerization initiators;intermediates & fine chemicals;pharmaceuticals;calcium channel;ion channels;dihydropyridine;pharmaceutical intermediate;isotopically labeled pharmaceutical reference standard;capoten;cardiovascular apis;cardiovascular drugs
mol file: 21829-25-4.mol
nifedipine structure
nifedipine chemical properties
mp 171-175 °c
storage temp. 2-8°c
solubility dmso: soluble
form powder
color yellow
water solubility <0.1 g/100 ml at 19.5 ºc
merck 6528
cas database reference 21829-25-4(cas database reference)
nist chemistry reference nifedipine(21829-25-4)
epa substance registry system 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-( 2-nitrophenyl)-, dimethyl ester(21829-25-4)
safety information
hazard codes xn,xi
risk statements 22-36/37/38
safety statements 26-36
wgk germany 1
rtecs us7975000
hazardclass irritant
msds information
provider language
nifedipine english
sigmaaldrich english
acros english
nifedipine usage and synthesis
pharmacological effects nifedipine is a kind of dihydropyridine calcium antagonists, it can inhibit the ca2 + uptake of cardiac and vascular smooth muscles, and it can expand the coronary artery , increase coronary blood flow,and improve myocardial ischemic tolerance, at the same time, it can expand peripheral arteries and reduce peripheral vascular resistance,and relieve coronary artery spasm, and increase coronary blood flow, improve myocardial ischemia,in order to decrease the blood pressure. small doses do not affect blood pressure, when expanding coronary artery ,it is a better anti-angina drug .it is used for the prevention and treatment of angina pectoris,with no adverse effects on respiratory function, its efficacy is best particularly for angina pectoris coronary spasm and obstructive airway disease with angina , its efficacy is superior to β-blockers.it is also applied to all types of high blood pressure, including severe and resistant hypertension. treatment of refractory congestive heart failure may be taking this long. it is also used for the treatment of primary pulmonary hypertension, diffuse esophageal spasm and bronchial asthma, duodenal ulcers, urinary tract obstruction, exercise-induced asthma, achalasia.
nifedipine has a certain selectivity on vascular smooth muscles , the direct negative inotropic effect and denaturation effect on the heart are weak, systemic administration of it does not cause the heart rate slowing down ,on the contrary, the heart rate performances reflected increase.
the above information is edited by the chemicalbook of tian ye.
chemical properties yellow crystals. melting point 172-174 ℃. soluble in acetone, chloroform, ethyl acetate, dissolved in hot methanol, insoluble in water. it easily deteriorates in case of light.
application long-term coronary vasodilators. this product can increase coronary blood flow, reducing myocardial oxygen consumption.it is used for acute and chronic coronary insufficiency,especially the angina and myocardial infarction.
production methods o-nitrobenzaldehyde, methyl acetoacetate, methanol, ammonia are refluxed together , then froze , crystallize,after filtration, nifedipine crude is obtained . the crude product is recrystallized through methanol .then the product is derived , yield rate is 50%.
category toxic substances
toxicity grading highly toxic
acute toxicity oral - rat ld50: 1022 mg / kg; oral - mouse ld50: 310 mg / kg.
flammability and hazard characteristics combustion produces toxic fumes of nitrogen oxides; medicinal side effects: low blood pressure, cardiac disease, local blood flow disease, high blood sugar, psychosis.
storage characteristics ventilated , low-temperature, drying; and it is kept separately from food raw materials warehouse.
extinguishing agent dry powder, foam, sand, carbon dioxide, water spray.
chemical properties yellow crystalline solid
usage used as an antihypertensive and antianginal. a dihydorpyridine calcium channel blocker
usage for the management of vasospastic angina, chronic stable angina, hypertension, and raynaud's phenomenon. may be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents).
general description odorless yellow crystals or powder. tasteless.
air & water reactions aqueous solutions are very sensitive to light. . insoluble in water.
reactivity profile nifedipine is sensitive to light.
fire hazard flash point data for nifedipine are not available; however, nifedipine is probably combustible.
biological activity l-type calcium channel blocker.

hennan sunlake enterprise corporation is located in henan province , the central plain of china , which enjoys favorable geogeaphical position and convenient transportion, the com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
sunlake is a professional manufacturer engaged in producing and selling chemicals,including organic & inorganic chemicals , pigments & dyestuffs , water treatment chemicals , food & feed additives and others . these products have been being well exported to europe , southeast asia , the middle east , africa , south america and some other countries and areas.

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