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Hubei Langyou International Trading Co., LtdPazopanib Manufacturer 444731-52-6 For Anticancer//file1.lookchem.com/300w/substances/2022-02-14-04/03543420-911f-433a-bd56-6e320cef2699.png
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Pazopanib Manufacturer 444731-52-6 For Anticancer CAS NO.444731-52-6

Min.Order Quantity:
10 Gram
Purity:
99%
Port:
Wuhan
Payment Terms:
T/T,MoneyGram

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Product Details

Keywords

  • 99%min Pazopanib
  • Pazopanib Manufacturer
  • For Anticancer

Quick Details

  • ProName: Pazopanib Manufacturer 444731-52-6 For...
  • CasNo: 444731-52-6
  • Molecular Formula: C21H23N7O2S
  • Appearance: White Powder
  • Application: It Can Be Used As Pharmaceutical Inte...
  • DeliveryTime: 2-4 days after confirming your payment...
  • PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
  • Port: Wuhan
  • ProductionCapacity: 10000 Metric Ton/Month
  • Purity: 99%
  • Storage: Store in sealed containers at cool & d...
  • Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
  • LimitNum: 10 Gram

Superiority

advantages:

hubei xinrunde chemical co., ltd is a renowned pharmaceutical manufacturer. we can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. never stop striving to offer our best service is our philosophy. we have flexible and untraceable payment terms. as a leading manufacture, our products have been exported to germany, norway, poland, finland, spain, uk, france, russia, usa, brazil, mexico, australia, japan, korea, thailand, indonesia, uruguay and many other countries.

1. quality.every batch of steroid powders have tobetested by our qc(quality control) before they are allowed to sell.


2. delivery we have stock, so we can delivery quickly at the very day when receive the payment. within 24 hours after receiving the payment lead time 4 or 7 days.


3. discreet package safelyand professionally disguised package guaranteed. for your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.


4. warm after-sale service any of your question would be solved for the first as soon as possible.

Details

pazopanib basic information
product description the efficacy of the treatment of advanced renal cell carcinoma adverse reactions
product name: pazopanib
synonyms: pazopanib for research;5-[[4-[(2,3-dimethyl-2h-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;pazopanib;pazopanib(gw786034);5-(4-((2,3-dimethyl-3,3a-dihydro-2h-indazol-6-yl)(methyl)amino)pyrimidin-2-ylamino)-2-methylbenzenesulfonamide;5-[(4-{[(2,3-dimethyl-2h-indazol-6-yl)methyl]amino}pyrimidin-2-yl)amino]-2-methylbenzene-1-sulfonamide;5-({4-[(2,3-dimethyl-2h-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide 5-(4-(n-(2,3-dimethyl-2h-indazole-6-yl)- n-methylamino)pyrimidine-2-ylamino)-2-methylbenzenesulfonamide;votrient
cas: 444731-52-6
mf: c21h23n7o2s
mw: 437.52
einecs:
product categories: intermediates & fine chemicals;pharmaceuticals;hfc80010;inhibitors
mol file: 444731-52-6.mol
pazopanib structure
pazopanib chemical properties
melting point 285-289°c (dec.)
density 1.40
fp 359℃
storage temp. refrigerator
safety information
risk statements 43-62/63
safety statements 36/37/39-28b
pazopanib usage and synthesis
product description pazopanib is researched and developed by a glaxosmithkline ,it is a novel oral vascular generation inhibitor which may interfere stubborn tumor survival and new blood vessels generation growth needed .targeting vascular endothelial growth factor receptor (vegfr),it works by inhibiting angiogenesis of tumor blood supply.it is suitable for advanced renal cell carcinoma ( a discovery of cancer cells in the renal tubules), soft tissue sarcoma (sts), epithelial ovarian cancer and non-small cell lung cancer (nsclc) treatment.
minnesota rochester, mayo clinical research clinical research center researches show that pazopanib (trade name votrient) can effectively cure thyroid cancer,and can make half of the patients tumor volume reduced, compared to the commonly used drugs ,it is more prolonged stable ,and can be maintained for a considerable period of treatment, the drug has the highest response rate in treatment of thyroid cancer so far.
the us food and drug administration (fda) approved on october 19, 2009 that pazopanib (trade name votrient) is listed ,the sixth approved drug treatment of kidney cancer since 2005. in 2009, approximately 49,000 patients were diagnosed with renal cell carcinoma, 11,000 patients died of the disease.
june 15, 2010, pazopanib, eu conditionally approved it for advanced renal cell cancer and first-line treatment in patients with previously received cytokine therapy. once the european commits to give final marketing authorization for this drug, glaxosmithkline will have exclusive marketing rights pazopanib for ten years.
chemical properties off-white solid
uses pazopanib hydrochloride (gw786034, votrient, armala) is a novel multi-target inhibitor of vegfr1, vegfr2, vegfr3, pdgfr, fgfr, c-kit and c-fms with ic50 of 10 nm, 30 nm, 47 nm, 84 nm, 74 nm, 140 nm and 146 nm, respectively.
uses pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of vegfr1, vegfr2, vegfr3, pdgfr-α/β, and c-kit.
uses pazopanib is a novel multi-target inhibitor of vegfr1, vegfr2, vegfr3, pdgfr, fgfr, c-kit and c-fms with ic50 of 10 nm, 30 nm, 47 nm, 84 nm, 74 nm, 140 nm and 146 nm, respectively.
uses an oral angiogenesis inhibitor targeting vegfr and pdgfr.
definition chebi: a pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. used as its hydrochloride salt for treatment of kidney cancer.

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