Pemetrexed disodium hydrate CAS NO.357166-30-4

character almost-white or light yellow unfixed powder, smell-less, hygroscopic freely. solubility soluble in water very freely, in ethanol or chloroform or ethyl ether hardly. specific optical rotation +10°－+16° identification (1)the product appears flame reaction of sodium salt. (2)uv:max absorption at 225nm wavelength. (3)ir:meet the requirements. ph 6.5－8.0 clarity and color of solution meet the requirements. related substance max single impurity≤0.1% total impurity≤0.5% optical isomer ≤0.500% heavy metal <20ppm ethanol dichloromethane ethyl acetate dmf ≤0.500% ≤0.060% ≤0.500% ≤0.088% water 7.2%－10.2% assay not less than 98.50%, calculated on the anhydrous basis.