HENAN SUNLAKE ENTERPRISE CORPORATION
- Country:
China (Mainland) - Year Established: 2010
- Business type: Trading Company
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Pranlukast CAS NO.103177-37-3
- Min.Order Quantity:
- 1 Kilogram
- Purity:
- 98%
- Port:
- China Main Port
- Payment Terms:
- L/C,D/A,D/P,T/T,Other
Product Details
Keywords
- Pranlukast
- 103177-37-3
- C27H23N5O4
Quick Details
- ProName: Pranlukast
- CasNo: 103177-37-3
- Molecular Formula: C27H23N5O4
- Appearance: powder
- Application: 103177-37-3
- DeliveryTime: within 3-7 days
- PackAge: as requested
- Port: China Main Port
- ProductionCapacity: 300 Kilogram/Month
- Purity: 98%
- Storage: store in cool, dry place
- Transportation: by sea or by air
- LimitNum: 1 Kilogram
Superiority
| pranlukast basic information |
| product name: | pranlukast |
| synonyms: | pranlukast;4-oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4h-1-benzopyranh;benzamide,n-(4-oxo-2-(1h-tetrazol-5-yl)-4h-1-benzopyran-8-yl)-4-(4-phenylbutox;emihydrate;hemihydrate;n-(4-oxo-2-(1h-tetrazol-5-yl)-4h-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzam;ono1078;rs411 |
| cas: | 103177-37-3 |
| mf: | c27h23n5o4 |
| mw: | 481.5 |
| einecs: | 201-616-4 |
| product categories: | antiasthmatic;inhibitors;intermediates & fine chemicals;pharmaceuticals;aromatics;heterocycles;api |
| mol file: | 103177-37-3.mol |
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| pranlukast chemical properties |
| melting point | 236-238°c |
| storage temp. | store at +4°c |
| cas database reference | 103177-37-3(cas database reference) |
| safety information |
| hazard codes | f,c |
| risk statements | 11-34 |
| safety statements | 16-26-36/37/39-45 |
| pranlukast usage and synthesis |
| asthma drugs |
pranlukast is a common respiratory drug, it belongs to asthma drugs , it is the cysteinyl leukotrienes (lts) receptor antagonist and it can bind to ltc4, ltd4, lte4 receptors selectively to antagonize their effect . roles and application are similar to zafirlukast. it is clinically used for the prevention of bronchial asthma. oral 225mg once, 2 times one day, morning and evening after meal. after taking ,there may be gastrointestinal reactions,or there may be nausea, vomiting, abdominal pain, diarrhea or constipation, sometimes , fever, rash, pruritus and liver function abnormalities such as serum aminotransferase or bilirubin increase are visible . pregnant women should use with caution , the elderly should take appropriate reductions. this product can not alleviate the onset of asthma. at present, three leukotriene receptor antagonists are used for the following purposes: 1, zafirlukast :it is effective for mild to moderate asthma ,it can cause improvement in dose-dependent lung function, and reduce the amount of β agonists. absorption of the product is affected by food, it should not be taken together with food. oral each 20mg, 2 times / d. 2, montelukast: it is valid for intermittent or persistent asthma in adults and children. this product is approved by the fda for the treatment of children aged 6 to 12. absorption of the product is not affected by food, it can be taken with food . oral each 10mg, once / d. 3, pranlukast :it is used for mild to moderate asthma, pranlukast can increase patients maximum expiratory flow,and improve asthma symptoms, it can be used as a daily treatment of chronic asthma. each oral 450mg, 2 times / d. the above information is edited by the chemicalbook of tian ye. |
| chemical properties | off-white solid |
| usage | a potent, selective and orally active cyslt receptor antagonist. leukotriene antagonist. used as an antiasthmatic |
| usage | antiasthmatic;leukotriene receptor-1 antagonist |
| usage | labeled pranlukast, intended for use as an internal standard for the quantification of pranlukast by gc- or lc-mass spectrometry. |
| biological activity | selective cysteinyl leukotriene receptor 1 (cyslt 1 ) antagonist (ic 50 values are ~ 4-7 and 3620 nm for cyslt 1 and cyslt 2 respectively). inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. can decrease symptoms of bronchial asthma. |
| pranlukast preparation products and raw materials |
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