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HENAN SUNLAKE ENTERPRISE CORPORATIONPranlukast//file1.lookchem.com/300w/synthetic/2022-01-31-03/0a651b18-c9e8-4e27-ab9f-0c92955c37c9.png
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Pranlukast CAS NO.103177-37-3

Min.Order Quantity:
1 Kilogram
Purity:
98%
Port:
China Main Port
Payment Terms:
L/C,D/A,D/P,T/T,Other

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Product Details

Keywords

  • Pranlukast
  • 103177-37-3
  • C27H23N5O4

Quick Details

  • ProName: Pranlukast
  • CasNo: 103177-37-3
  • Molecular Formula: C27H23N5O4
  • Appearance: powder
  • Application: 103177-37-3
  • DeliveryTime: within 3-7 days
  • PackAge: as requested
  • Port: China Main Port
  • ProductionCapacity: 300 Kilogram/Month
  • Purity: 98%
  • Storage: store in cool, dry place
  • Transportation: by sea or by air
  • LimitNum: 1 Kilogram

Superiority

pranlukast basic information
asthma drugs
product name: pranlukast
synonyms: pranlukast;4-oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4h-1-benzopyranh;benzamide,n-(4-oxo-2-(1h-tetrazol-5-yl)-4h-1-benzopyran-8-yl)-4-(4-phenylbutox;emihydrate;hemihydrate;n-(4-oxo-2-(1h-tetrazol-5-yl)-4h-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzam;ono1078;rs411
cas: 103177-37-3
mf: c27h23n5o4
mw: 481.5
einecs: 201-616-4
product categories: antiasthmatic;inhibitors;intermediates & fine chemicals;pharmaceuticals;aromatics;heterocycles;api
mol file: 103177-37-3.mol
pranlukast structure
pranlukast chemical properties
melting point 236-238°c
storage temp. store at +4°c
cas database reference 103177-37-3(cas database reference)
safety information
hazard codes f,c
risk statements 11-34
safety statements 16-26-36/37/39-45
msds information
pranlukast usage and synthesis
asthma drugs pranlukast is a common respiratory drug, it belongs to asthma drugs , it is the cysteinyl leukotrienes (lts) receptor antagonist and it can bind to ltc4, ltd4, lte4 receptors selectively to antagonize their effect . roles and application are similar to zafirlukast. it is clinically used for the prevention of bronchial asthma. oral 225mg once, 2 times one day, morning and evening after meal. after taking ,there may be gastrointestinal reactions,or there may be nausea, vomiting, abdominal pain, diarrhea or constipation, sometimes , fever, rash, pruritus and liver function abnormalities such as serum aminotransferase or bilirubin increase are visible . pregnant women should use with caution , the elderly should take appropriate reductions. this product can not alleviate the onset of asthma.
at present, three leukotriene receptor antagonists are used for the following purposes:
1, zafirlukast :it is effective for mild to moderate asthma ,it can cause improvement in dose-dependent lung function, and reduce the amount of β agonists. absorption of the product is affected by food, it should not be taken together with food. oral each 20mg, 2 times / d.
2, montelukast: it is valid for intermittent or persistent asthma in adults and children. this product is approved by the fda for the treatment of children aged 6 to 12. absorption of the product is not affected by food, it can be taken with food . oral each 10mg, once / d.
3, pranlukast :it is used for mild to moderate asthma, pranlukast can increase patients maximum expiratory flow,and improve asthma symptoms, it can be used as a daily treatment of chronic asthma. each oral 450mg, 2 times / d.
the above information is edited by the chemicalbook of tian ye.
chemical properties off-white solid
usage a potent, selective and orally active cyslt receptor antagonist. leukotriene antagonist. used as an antiasthmatic
usage antiasthmatic;leukotriene receptor-1 antagonist
usage labeled pranlukast, intended for use as an internal standard for the quantification of pranlukast by gc- or lc-mass spectrometry.
biological activity selective cysteinyl leukotriene receptor 1 (cyslt 1 ) antagonist (ic 50 values are ~ 4-7 and 3620 nm for cyslt 1 and cyslt 2 respectively). inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. can decrease symptoms of bronchial asthma.
pranlukast preparation products and raw materials

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