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Henan Tianfu Chemical Co., Ltd.Pyrimethamine//file1.lookchem.com/cas/reactions/2021/07/13/219864.png
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Pyrimethamine CAS NO.58-14-0

Min.Order Quantity:
1 Metric Ton
Purity:
99.0%Min
Port:
Any port of China
Payment Terms:
L/C,T/T,

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Product Details

Keywords

  • Pyrimethamine
  • 58-14-0
  • C12H13ClN4

Quick Details

  • ProName: Pyrimethamine
  • CasNo: 58-14-0
  • Molecular Formula: C12H13ClN4
  • Appearance: conform
  • Application: For pharmacy
  • DeliveryTime: with 10 days after order confirmed
  • PackAge: according to the demand of cusotmer
  • Port: Any port of China
  • ProductionCapacity: 1 Metric Ton/Day
  • Purity: 99.0%Min
  • Storage: Room Temperature
  • Transportation: shipped
  • LimitNum: 1 Metric Ton

Superiority

our company was built in 2009 with an iso certificate.in the past 5 years, we have grown up as a famous fine chemicals supplier in china and we had established stable business relationships with samsung,lg,merck,thermo fisher scientific and so on.our main business covers the fields below:

1.noble metal catalysts (pt.pd...)

2.organic phosphine ligands (tert-butyl-phosphine.cyclohexyl-phosphine...)

3.oled intermediates (fluorene,carbazole,boric acid...)

4.customs synthesis

our advantage:

1. higest quality and good package

2.fast delivery

3.better payment term

4.fast response to customer within 6 hours

5.good business credit in europe ,us ,japan ,korea

anyway ,if you need any chemicals from china ,henan tianfu can help you

Details

pyrimethamine basic information
product name: pyrimethamine
synonyms: 2,4-diamino-5-(4-chlorophenyl)-6-ethylpyrimidine;2,4-diamino-5-chlorophenyl-6-ethylpyrimidine;2,4-pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-;2,4-pyrimidinediamine, 5-(p-chlorophenyl)-6-ethyl-;2,4-pyrimidinediamine,5-(4-chlorophenyl)-6-ethyl-;4753 r.p.;4753r.p.;5-(4’-chlorophenyl)-2,4-diamino-6-ethylpyrimidine
cas: 58-14-0
mf: c12h13cln4
mw: 248.71
einecs: 200-364-2
product categories: apis & intermediate;pyrimidine;organics;amines;bases & related reagents;heterocycles;intermediates & fine chemicals;nucleotides;pharmaceuticals;inhibitor;heterocycle-pyrimidine series;daraprim
mol file: 58-14-0.mol
pyrimethamine structure
pyrimethamine chemical properties
mp 233-234°c
storage temp. 0-6°c
water solubility <0.01 g/100 ml at 21 ºc
stability: stable, but light sensitive. combustible. incompatible with strong oxidizing agents.
cas database reference 58-14-0(cas database reference)
nist chemistry reference pyrimethamine(58-14-0)
epa substance registry system 2,4-pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl- (58-14-0)
safety information
hazard codes xn
risk statements 22
ridadr 3249
wgk germany 3
rtecs uv8140000
hazardclass 6.1(b)
packinggroup iii
msds information
pyrimethamine usage and synthesis
chemical properties white solid
usage dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. antiprotozoal (toxoplasma); antimalarial
usage for the treatment of toxoplasmosis and acute malaria; for the prevention of malaria in areas non-resistant to pyrimethamine
general description odorless white crystalline powder. tasteless. an antimalarial drug.
air & water reactions insoluble in water.
reactivity profile pyrimethamine is sensitive to exposure to light . neutralizes acids to form salts plus water in exothermic reactions. may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
fire hazard flash point data for pyrimethamine are not available; however, pyrimethamine is probably combustible.
biological activity potent inhibitor of multi-drug and toxin extrusion (mate) transporters (k i values are 46 and 77 nm for human mate2-k-hek293 and mate1-hek293 cells respectively). also inhibits dihydrofolate reductase (dhfr).
pyrimethamine preparation products and raw materials
raw materials ethyl propionate-->4-chlorobenzyl cyanide

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