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pyrimethamine basic information |
product name: | pyrimethamine |
synonyms: | 2,4-diamino-5-(4-chlorophenyl)-6-ethylpyrimidine;2,4-diamino-5-chlorophenyl-6-ethylpyrimidine;2,4-pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-;2,4-pyrimidinediamine, 5-(p-chlorophenyl)-6-ethyl-;2,4-pyrimidinediamine,5-(4-chlorophenyl)-6-ethyl-;4753 r.p.;4753r.p.;5-(4’-chlorophenyl)-2,4-diamino-6-ethylpyrimidine |
cas: | 58-14-0 |
mf: | c12h13cln4 |
mw: | 248.71 |
einecs: | 200-364-2 |
product categories: | apis & intermediate;pyrimidine;organics;amines;bases & related reagents;heterocycles;intermediates & fine chemicals;nucleotides;pharmaceuticals;inhibitor;heterocycle-pyrimidine series;daraprim |
mol file: | 58-14-0.mol |
pyrimethamine chemical properties |
mp | 233-234°c |
storage temp. | 0-6°c |
water solubility | <0.01 g/100 ml at 21 ºc |
stability: | stable, but light sensitive. combustible. incompatible with strong oxidizing agents. |
cas database reference | 58-14-0(cas database reference) |
nist chemistry reference | pyrimethamine(58-14-0) |
epa substance registry system | 2,4-pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl- (58-14-0) |
safety information |
hazard codes | xn |
risk statements | 22 |
ridadr | 3249 |
wgk germany | 3 |
rtecs | uv8140000 |
hazardclass | 6.1(b) |
packinggroup | iii |
msds information |
provider | language |
---|---|
2,4-diamino-5-(p-chlorophenyl)-6-ethylpyrimidine | english |
sigmaaldrich | english |
pyrimethamine usage and synthesis |
chemical properties | white solid |
usage | dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. antiprotozoal (toxoplasma); antimalarial |
usage | for the treatment of toxoplasmosis and acute malaria; for the prevention of malaria in areas non-resistant to pyrimethamine |
general description | odorless white crystalline powder. tasteless. an antimalarial drug. |
air & water reactions | insoluble in water. |
reactivity profile | pyrimethamine is sensitive to exposure to light . neutralizes acids to form salts plus water in exothermic reactions. may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. |
fire hazard | flash point data for pyrimethamine are not available; however, pyrimethamine is probably combustible. |
biological activity | potent inhibitor of multi-drug and toxin extrusion (mate) transporters (k i values are 46 and 77 nm for human mate2-k-hek293 and mate1-hek293 cells respectively). also inhibits dihydrofolate reductase (dhfr). |
pyrimethamine preparation products and raw materials |
raw materials | ethyl propionate-->4-chlorobenzyl cyanide |