Quetiapine fumarate CAS NO.111974-72-2

quetiapine fumarate basic information

antipsychotics chemical properties application

product name:	quetiapine fumarate
synonyms:	seroquel;quetiapine fumarate;quetiapine hemifumarate;2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate;dibenzothiazepinohonep;ici-204636;quetiapine fumarate, 99+%;quetiapine fumarate main intermediates
cas:	111974-72-2
mf:	c46h54n6o8s2
mw:	883.09
einecs:
product categories:	active pharmaceutical ingredients;antipsychotic;intermediates & fine chemicals;pharmaceuticals;quetiapine;api;pharmaceutical raw materials;bulk drug material;inhibitors
mol file:	111974-72-2.mol

quetiapine fumarate chemical properties

mp	174-176°c
storage temp.	-20°c freezer
cas database reference	111974-72-2(cas database reference)

safety information

hazard codes	xn,n,t,f
risk statements	22-50/53-52/53-39/23/24/25-23/24/25-11
safety statements	60-61-45-36/37-16

msds information

quetiapine fumarate usage and synthesis

antipsychotics	quetiapine fumarate is an antipsychotic, successfully developed by the astrazeneca united states, it interacts with a variety of neurotransmitter receptors, in the brain, it displays high degree affinity for serotonin (5-ht2) receptor, and it is greater than dopamine d1 and d2 dopamine receptor affinity in the brain. quetiapine also has high affinity for histamine h1 receptor and adrenergic α1 receptors, and low affinity for α2 receptors, but it basically displays no affinity for cholinergic muscarinic receptors or benzodiazepine receptors . it shows positive results in antipsychotic activity assays such as conditioned avoidance reflex . in clinical, it is mainly used in treatment for adults with severe depression, acute manic episodes of bipolar disorder and schizophrenia of different types . it is not only effective for the positive symptoms of schizophrenia, but also having a certain effect for negative symptoms . it can also alleviate affective symptoms associated with schizophrenia, such as depression, anxiety symptoms and cognitive deficits. the above information is edited by the chemicalbook of tian ye.
chemical properties	white crystalline powder.
application	a non-classical antipsychotics.
chemical properties	white crystalline solid
usage	used as an antipsychotic. benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties
usage	antihypertensive adrenergic receptor blocking agent with selective alpha1- and nonselective beta-adrenergic receptor blocking actions in a single substance.

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