SB202190 CAS NO.152121-30-7

sb 202190 is a highly selective, potent and cell-permeable inhibitor of p38 map kinase,sb202190 binds within the atp pocket of the active kinase (kd = 38 nm, as measured in recombinant human p38), and selectively inhibits the p38 α and β isoforms (ic50 = 50 and 100 nm at sapk2a/p38 and sapk2b/p38 β 2 respectively).

references:

[1]. davies et al (2000) specificity and mechanism of action of some commonly used protein kinase.inhibitors. biochem.j. 351 95.

[2]. karahashi h et al a selective inhibitor of p38 map kinase, sb202190, induced apoptotic cell death of a lipopolysaccharide-treated macrophage-like cell line, j774.1 biochim biophys acta. 2000 oct 18;1502(2):207-23.

[3]. winnicki k, maszewski j.sb202190 affects cell response to hydroxyurea-induced genotoxic tress in root meristems of vicia faba.plant physiol biochem. 2012 aug 13;60c:129-136.

[4]. keshari rs, verma a, barthwal mk, dikshit m.reactive oxygen species-induced activation of erk and p38 mapk mediates pma- induced nets release from human neutrophils.j cell biochem.2012 sep 7.

[5]. zbinden-foncea h, deldicque l, pierre n, francaux m, raymackers jm.tlr2 and tlr4 activation induces p38 mapk-dependent phosphorylation..