SB202190 CAS NO.152121-30-7

prouduct name:sb202190

chemical name: 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1h-imidazol-2-yl]phenol

m.wt:331.35

formula:c₂₀h₁₄n₃of

appearance:yellow powder

solubility:soluble to 100 mm in dmso

purity:>99 %

storage:store at -20°c

cas no:152121-30-7

sb 202190 significantly inhibits both basal and anti-fas antibody-induced mapkapk 2 activity in a dose-dependent manner. sb202190 by itself is sufficient to induce cell death in jurkat and hela cells through activation of cpp32-like caspases, which can be blocked by expression of bcl-2. sb202190-induced apoptosis is attenuated by p38β but augmented by p38α. sb 202190 strongly inhibits uvb induced cox-2 protein expression in hacat cells, and markedly inhibits uvb induced cox-2 mrna. sb 202190

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