Sacubitril CAS NO.149709-62-6

product description

1 basic information

ssda00398 ahu-377 (sacubitril) 149709-62-6
ahu-377 (sacubitril) 149709-62-6	cas 149709-62-6	brand sunsanta
	mf c24h29no5	msds:aviable
	mw 532.6	place of origin:china
	synonym: sacubitril
ahu-377 (sacubitril) description	ahu-377 (sacubitril) is a prodrug which is activated in vivo by hydrolytic enzyme esterases to form an active compound lbq657 that selectively and potently inhibits the enzyme neprilysin with ki at low nm. neprilysin is a protease responsible for the degradation of atrial and brain natriuretic peptides. inhibition of the enzyme prevents the degradation of natriuretic peptides and activates cgmp signaling pathways that regulate volume and blood pressure. ahu-377 (sacubitril) is an investigational antihypertensive drug being studied for use in combination with valsartan (molar ratio: 1:1) (our prod no. ct-vals). the combination drug, known as lcz696, is in clinical trials for the treatment of heart failure.
ahu-377 (sacubitril) structual
purity	99% min
ahu-377 (sacubitril) storage condition	store at 0°c (short term), -20°c (long term) desiccated
ahu-377 documents provide	coa ,msds ,nhmr spectrum,sample package avaiable

2 package details:

for small quantity: bag commercial quantity: fiber drumfor small quantity: bag commercial quantity: fiber drumfor small quantity: bag commercial quantity: fiber drum

3 company profile:

changzhou sunsanta trading co.,ltd is located in changzhou,jiangsu,china,
it is dedicated to developing, manufacturing and marketing of pharmaceutical
intermediates, apis and fine & speciality chemicals. our main products are
amino acid and their derivatives, anti-virus, anti-depresant, pril products,
and other intermediates.we own in indepedent r&d center in jiangsu provice
and plants in shanghai and zhejiang provice. supported by our highly qualified
team of professional and technicals, we have rich experience in a wide range of
chemical reactions. besides, we have professional abilities to fully support
clients with all technical certifications and efficient regulatory documents.
we have successfully established a sales network worldwide, esp europe, southeast
asia and africa market. quality, creativeness and services is our motto. we value
more special service according to client's requirements.