Superior Hydroxyapatite CAS 1306-06-5 for Tooth Enamel CAS NO.1306-06-5

1. quick detail:

hydroxyapatite
synonym: tricalcium phosphate (tcp); mono calcium phosphate(mcp)
inchi: inchi=1/5ca. 3h3o4p. h2o/c; ; ; ; ; 3*1-5(2, 3)4; /h; ; ; ; ; 3*(h3, 1, 2, 3, 4); 1h2/q5*+2; ; ; ; /p-10
cas no.: 1306-06-5
einecs no.: 215-145-7
mf: ca5. (oh). (po4)3
mw: 502.31
melting point: 1700º c
boiling point: 158º c at 760 mmhg
water: h2o: 0.3 mg/ml, clear, colorless
solubilities: h2o: 0.3 mg/ml, clear, colorless
appearance: white powder
grade: pharmaceutical grade and food grade
place of origin: wuhan, china
lead time: 1-2 days upon receipt of payment
delivery time: usually 4-6 working days by air
storage: shading, confined preservation, 2-8° c
usage: pharmaceutical raw materials, food additives



2. application:

hydroxylapatite can be found in teeth and bones within the human body. thus, it is commonly used as a filler to replace amputated bone or as a coating to promote bone ingrowth into prosthetic implants. although many other phases exist with similar or even identical chemical makeup, the body responds to them very differently. coral skeletons can be transformed into hydroxylapatite by high temperatures; their porous structure allows relatively rapid ingrowth at the expense of initial mechanical strength. the high temperature also burns away any organic molecules such as proteins, preventing an immune response and rejection.
many modern implants, e. g. hip replacements, dental implants and bone conduction implants, are coated with hydroxylapatite. it has been suggested that this may promoteosseointegration...porous hydroxylapatite implants are used for local drug delivery in bone. it is also being used to repair early lesions in tooth enamel.
2.1 pathology
hydroxylapatite deposits in tendons around joints resulting in the medical condition calcific tendinitis.
2.2 supplement
microcrystalline hydroxylapatite (mh) is marketed as a "bone-building" supplement with superior absorption in comparison to calcium. it is a second-generation calcium supplement derived from bovine bone. in the 1980s, bone meal calcium supplements were found to be contaminated with heavy metals, and although the manufacturers claim their mh is free from contaminants, people are advised to avoid it because it has not been well-tested. however, the limited tests seem to show positive results. a 1995 randomized placebo-controlled study of 40 people in europe found that it was more effective than calcium carbonate in slowing bone loss. a 2007 randomized double-blind controlled study of an mh supplement called the bone builder found significant positive effects in bone mineral density (bmd) compared to control. hydroxylapatite has been used by noel fitzpatrick to facilitate bionic development in animals, by coating steel rods in hydroxylapatite to encourage natural growth of skin around it. as a component of nanocomposites, hydroxylapatite is finding uses as a potential new bone replacement materials.