TIANFU-CHEM - Biapenem CAS NO.120410-24-4

Min.Order Quantity:: 1 Kilogram

Purity:: 98%

Port:: Shanghai

Payment Terms:: L/C,D/A,D/P,T/T,MoneyGram,Other

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Product Details

Keywords

Biapenem
120410-24-4
C15H18N4O4S

Quick Details

ProName: TIANFU-CHEM - Biapenem
CasNo: 120410-24-4
Molecular Formula: C15H18N4O4S
Appearance: Off-White Solid
Application: Organic synthesis
DeliveryTime: Prompt
PackAge: IN 25kg drums
Port: Shanghai
ProductionCapacity: 10 Metric Ton/Month
Purity: 98%
Storage: room tempurature
Transportation: As per the MSDS
LimitNum: 1 Kilogram
Heavy metal: N/A
Grade: Industrial Grade,Food Grade,Pharma Gra...
N/A: N/A

Superiority

our company engages in sodium tripolyphosphate (stpp) and sodium hexametabphosphate (shmp) production; development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals imp&exp trading business. the company is located in zhengzhou high-tech development zone with import and export license. we passed iso 9001:2008 in 2009, and won "high-tech enterprise" by provincial government in 2013. our stpp and shmp has reached an annual output of 30000 tons and has successfully passed sgs, ciq audits on many occasions.

in 2011 we entered the fine chemical market of noble metal catalyst ,organic phosphine ligands and oled intermediates.with the joint efforts of our senior experts and professional technicians, tianfu has developed more than 500 compounds, which are widely used in the fields of production and life science. the objective of the company is to put quality first and put our customer’s needs first - the satisfaction of our customers is the company's ultimate goal. improving product quality and service level is our responsibility, and creating more value for our customer’s is our purpose. we are constantly striving to make henan tianfu a leading chemical supplier, and hope to create a better future with you.

Details

biapenem basic information

new carbapenem antibiotic (carbapenem family members) antibacterial activity indications intellectual property status uses

product name:	biapenem
synonyms:	6-[[(4r,5s,6s)-2-carboxy-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5h-pyrazolo[1,2-a][1,2,4]triazol-4-ium inner salt;biapenem;6-[[(4r,5s,6s)-2-carboxy-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5h-pyrazolo[1,2-a][1,2,4]triazol-4-ium inner salt;(4r,5s,6s)-3-(6,7-dihydro-5h-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylthio)-6-((r)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate;6-[[(4r,5s,6s)-2-carboxylato-6β-[(1r)-1-hydroxyethyl]-4α-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5h-pyrazolo[1,2-a]-s-triazol-4-ium;6-[[(4r,5s,6s)-2-carboxylato-6β-[(r)-1-hydroxyethyl]-4α-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5h-pyrazolo[1,2-a][1,2,4]triazol-4-ium;6-[[(4r,5β)-2-carboxylato-4α-methyl-6β-[(r)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5h-pyrazolo[1,2-a][1,2,4]triazol-4-ium;l-627
cas:	120410-24-4
mf:	c15h18n4o4s
mw:	350.39
einecs:	204-352-8
product categories:	api;chiral;antibacterial;pharmaceutical intermediates;chiral compounds;intermediates & fine chemicals;pharmaceuticals;sulfur & selenium compounds;pharmaceutical intermediate;pharmaceutical raw material;l-627, ljc 10627;inhibitors
mol file:	120410-24-4.mol

biapenem chemical properties

melting point	265-271°c (dec.)
storage temp.	-20 c freezer
cas database reference	120410-24-4(cas database reference)

safety information

msds information

biapenem usage and synthesis

new carbapenem antibiotic (carbapenem family members)	biapenem, together with several drugs developed in different companies in the united state, japan, and china, all belong to the rapid-developing carbapenem family members. it is white to yellowish white crystalline powder, and is a kind of carbapenem-class antibiotics for injection developed by both the lederle company in japan and the cyanamid company in the united state in 1989. it has a broad antibacterial spectrum and has an excellent bactericidal effect on gram-negative, gram-positive, aerobic and anaerobic bacteria. the c1 position of its structure contains a 1β-methyl group which can enable drugs to be stable to the effects of the dehydropeptidase i (dhp-i) in the human kidney without the necessity to be combined with dhp-i inhibitor for therapy, and thus reducing its renal toxicity, and is also stable to β- lactamase stability; it also has excellent pharmacokinetic properties and low toxicity; it has excellent therapeutic effect on treating various diseases such as concurrent intra-abdominal infections, plastic surgery infections, gynecological infections, ent infections, lower respiratory tract infections (including bacterial pneumonia), and also concurrent urinary tract infections with a good tolerance and a lower incidence of adverse reactions. a notable feature of this product is the existence of the 1β-methyl carbapenem (containing bicyclic triazole) located at the s at 2-position. structure-function relationship studies have showed that the presence of quaternary ammonium cation located in the side chain is the key that affects the outer membrane permeability, making the inhibitory effect of the product on pseudomonas aeruginosa and anaerobic bacteria be 2 to 4 times as potent as that of imipenem, and the inhibitory effect on the drug-resistant pseudomonas aeruginosa be 4 to 8 times as potent as that of meropenem, and moreover, making it more effective in treating acinetobacter spp, anaerobic bacteria than ceftazidime. thus, it is promising that it is expected to become a novel first-line drug for treating severe infection. the general dose for intravenously infusion of biapenem is about 300mg with time being 30 ~ 60min at 2 times per day.
antibacterial activity	studies have shown that biapenem has broad-spectrum and potent antibacterial activity against g+ bacteria, g- as well as anaerobic bacteria, etc. mic90 range of this product against 456 clinical isolates of g + bacteria was 0.006 ~ 3.13μg / ml; for 1145 g- bacteria, the mic90 range is 0.1 ~ 3.13μg/ml with its antibacterial activity being 2 times as strong as imipenem; for most anaerobes, the mic90 range is 0.05 ~ 1.56μg/ml. biapenem has broad-spectrum antimicrobial activity. the antimicrobial activity of it is similar as that of imipenem and meropenem, and stronger than that latamoxef and ceftazidime. the mic value and mbc values are ??similar with each other for this drug. upon mic concentration, it can cause morphological changes of pseudomonas aeruginosa and escherichia coli; upon a concentration higher than mic, the bacteria exhibits lytic phenomenon. staphylococcus aureus, gpb, streptococcus pyogenes and streptococcus pneumoniae are highly sensitive to the drug; but methicillin-resistant staphylococcus aureus and gpb are also resistant to this drug. in addition, this product also has excellent antibacterial activity against bacteriodes fragilis also with mic90 being 1.56μg /ml. the research of ichiro murakami has shown that this antibacterial activity against clinical isolates of g + bacteria and enterobacteriaceae of this drug is similar as or slightly weaker than that of imipenem, but with a stronger anti-bacterial activity against enterobacteriaceae family than imipenem; for non g- fermentation bacteria, especially pseudomonas aeruginosa and gm-resistant pseudomonas aeruginosa, this antibacterial activity of this drug is two times as strong as imipenem. biapenem has a high affinity to the protein pbp2 and pbp4 of pseudomonas aeruginosa, exhibiting its excellent antibacterial activity and low endotoxin release property during the bactericidal process. in 2001, the study of japanese scholars (hiraishi.t) had shown that the transient bactericidal action of biapenem against pseudomonas aeruginosa pao1 is superior to that of meropenem. in 2005, during the comparison of transient bactericidal effects against pseudomonas aeruginosa for biapenem, imipenem, and meropenem, japanese scholars (shimauchi.c) found that biapenem has a best bactericidal activity within the same treatment time. the above information is edited by the chemicalbook of dai xiongfeng.
indications	sensitive strains of the drugs include: staphylococcus aureus, streptococcus pneumoniae, enterococcus (except enterococci faecium), moraxella, escherichia coli, citrobacter, klebsiella, enterobacter, serratia, proteus, haemophilus influenzae, pseudomonas aeruginosa, actinomyces, peptostreptococcus, bacteroides, prevotella, fusobacterium spp. this product is suitable for treating sensitive bacteria induced treatment sepsis, pneumonia, lung abscess, secondary infection caused by chronic respiratory disease, intractable cystitis, pyelonephritis, peritonitis, complicated cystitis, uterus annex inflammation, and gynecological annex inflammation go far.
intellectual property status	this product was developed by lederle company (japan) and cyanamid company (the united states) in 1989, as a novel kind of 1β- methyl carbapenem antibiotics which entered into market in japan in march 2002. after searching, the domestic development of this product doesn’t constitute infringement to the patents in other countries; there are also no administrative protection restrictions on it.
uses	1. it is a kind of total synthesis gatifloxacin antibacterial drug. 2. biapenem is a kind of carbapenem synthetic antibiotic. its salt form is white or off-white powder. it is soluble in water, but insoluble in common organic solvents. it is more stable to the action of renal dehydropeptidase than meropenem and is not necessary to be combined with the enzyme inhibitor. it can fight against gram-negative bacteria, especially with a stronger antibacterial activity against pseudomonas aeruginosa than imipenem; the antibacterial activity against aerobic gram-positive bacteria is slightly lower than that of imipenem; its anti-anaerobe activity is the same as imipenem.
chemical properties	off-white solid
usage	biapenem is a carbapenem antibiotic. it has in vitro activity against anaerobes. biapenem is a new parenteral carbapenem antibacterial agent with a broad spectrum of in vitro antibacterial activity encompassing many gram-negative and gram-positive aerobic
usage	an carbapenem antibacterial.
usage	a carbepenem with antibacterial action