TIANFUCHEM--2012-74-0--High purity High purity ALPHA-ISOPROPYL-4-CHLOROPHENYLACETIC ACID factory price CAS NO.2012-74-0

alpha-isopropyl-4-chlorophenylacetic acid

english synonyms: timtec-bb sbb008321; 4- (4-chlorophenyl) -3-methylbutanoic acid; 4- chloro-alpha- (1-methylethyl) -benzeneaceticaci; alpha- (p-chlorophenyl) isovaleric acid; benzeneacetic acid, -methyl-

cas number: 2012-74-0

molecular formula: c11h13clo2

molecular weight: 212.67

einecs number: 217-934-1

related categories: c11 to c12; carbonyl compounds; carboxylic acids; pyrethroid pesticides; pesticide intermediates; insecticide intermediates; aromatics; standards; organochlorine pesticides; insecticides; pharmaceutical ingredients; carboxymethyl acid

mol file: 2012-74-0.mol

α-isopropyl p-chlorophenylacetic acid

α-isopropyl p-chlorophenylacetic acid properties

melting point 87-91 ° c (lit.)

flash point> 230 ° f

cas database 2012-74-0 (cas database reference)

use and synthesis of α-isopropyl p-chlorophenylacetic acid

chemical properties 3-methyl-2- (4-chlorophenyl) butyric acid industrial products as light yellow or brown solid, pure white rhombohedral crystals, mp88 ~ 89 ℃, soluble in benzene, toluene, alcohol , acetone and other organic solvents, slightly soluble in water.

use 3-methyl-2- (4-chlorophenyl) butyric acid as butyric acid, fenvalerate, fenvalerate, chlorfenapyr important intermediates.

use pesticide intermediates.

use as intermediates in the production of pyrethroid pesticides

production methods α-isopropyl p-chlorophenyl acetonitrile hydrolysis derived. the α-isopropyl p-chlorophenylacetonitrile and 65% sulfuric acid molar ratio of 1: 1.3 were mixed, heated to 140-145 ° c for 11h. with solvent extraction, the acid layer was removed, and then washed with water, desolventizing, crystallization of α-isopropyl p-chlorophenylacetic acid, 90%, m.p. 85-87 ° c, yield 90%.

production method the preparation method is based on p-chlorotoluene as raw material, the side chain chlorination of chlorobenzyl chloride, and then reacted with sodium cyanide generated p-chloronitrile acetonitrile, and then with isopropyl bromide or isopropyl chloride reaction generated 3-methyl-2- (4-chlorophenyl) butyronitrile, followed by acidic hydrolysis to give 3-methyl-2- (4-chlorophenyl) butyric acid.

the formulated 65% sulfuric acid was put into the reaction kettle, and 3-methyl-2- (4-chlorophenyl) butyronitrile was put into the reaction kettle under stirring, the temperature was gradually raised to 143-145 ° c., the reaction was refluxed for 6 hours, cooled to room temperature, toluene extraction, still stratification, the separation of toluene solution, acid solution, and then extracted with toluene, toluene solution combined with 10% sodium hydroxide solution extracted twice with a small amount of toluene lye extraction, lye reuse 30% hydrochloric acid was acidified to ph = 1, extracted twice with toluene and the toluene layer was washed with saturated brine to ph = 6, de-toluene to give 3-methyl-2- (4- chlorophenyl) % ~ 85%.