Tacrolimus Manufacturer 104987-11-3 Rejection For Organ Transplantation CAS NO.104987-11-3

Min.Order Quantity:: 10 Gram

Purity:: 99%

Port:: Wuhan

Payment Terms:: T/T,MoneyGram

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Product Details

Keywords

99% Tacrolimus
Tacrolimus Manufacturer
Rejection For Organ Transplantation

Quick Details

ProName: Tacrolimus Manufacturer 104987-11-3 Re...
CasNo: 104987-11-3
Molecular Formula: C44H69NO12
Appearance: White Powder
Application: It Can Be Used As Pharmaceutical Inte...
DeliveryTime: 2-4 days after confirming your payment...
PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
Port: Wuhan
ProductionCapacity: 10000 Metric Ton/Month
Purity: 99%
Storage: Store in sealed containers at cool & d...
Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
LimitNum: 10 Gram

Superiority

advantages:

hubei xinrunde chemical co., ltd is a renowned pharmaceutical manufacturer. we can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. never stop striving to offer our best service is our philosophy. we have flexible and untraceable payment terms. as a leading manufacture, our products have been exported to germany, norway, poland, finland, spain, uk, france, russia, usa, brazil, mexico, australia, japan, korea, thailand, indonesia, uruguay and many other countries.

1. quality.every batch of steroid powders have tobetested by our qc(quality control) before they are allowed to sell.

2. delivery we have stock, so we can delivery quickly at the very day when receive the payment. within 24 hours after receiving the payment lead time 4 or 7 days.

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4. warm after-sale service any of your question would be solved for the first as soon as possible.

Details

tacrolimus basic information

product name:	tacrolimus
synonyms:	(2-propenyl)-,(3s-(3r(e(1s,3s,4s)),4s,5r,8s,9e,12r,14r,15s,16r,18s;,19s,26ar))-;16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1;19-epoxy-3h-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4h,23h)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-14,16-dim;6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-5;fr900506;prograf;tsukubaenolide
cas:	104987-11-3
mf:	c44h69no12
mw:	804.02
einecs:	1308068-626-2
product categories:	active pharmaceutical ingredients;immunosuppressant.;intermediates & fine chemicals;pharmaceuticals;api;chiral reagents;fujimycin, prograf;antibiotic;inhibitors
mol file:	104987-11-3.mol

tacrolimus chemical properties

melting point	113-115°c
fp	2℃
storage temp.	−20°c
solubility	dmso: >3 mg/ml
form	solid
color	white
water solubility	freely soluble in dmso or ethanol. poorly soluble in water.soluble in dimethyl sulfoxide, ethanol, water, acetone, chloroform, ethyl acetate, ether, methanol and dimethyl formamide.
cas database reference	104987-11-3(cas database reference)

safety information

hazard codes	t,xi,xn,f
risk statements	25-36/37/38-36-20/21/22-11
safety statements	45-36-26-36/37-16-60-20
ridadr	un 2811 6.1/pg 3
wgk germany	3
rtecs	kd4201200
hazardclass	6.1

tacrolimus usage and synthesis

chemical properties	white crystalline solid
uses	an immunosuppressant that blocks t cell proliferation in vitro by inhibiting the generation of several lymphokines, especially il-2. shown to inhibit the activity of fk-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum ca+2 release.
uses	fk-506 (tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system
uses	tacrolimus (fujimycin) was discovered as a potent inhibitor of il2 production in a targeted search for novel immunosuppressants. tacrolimus acts by blocking t cell proliferation in vitro by inhibiting the generation of several lymphokines, notably the original target il-2. tacrolimus inhibits the activity of fk-506 binding protein, ca2+-dependent phosphatase and calcineurin, and activates nf-κb through phosphorylation and degradation of iκbα.
uses	treatment of cushing's syndrome
uses	for use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. it was first approved by the fda in 1994 for use in liver transplantation, this has been extended to include kidney, heart,
definition	chebi: tacrolimus is a macrolide containing a 23-membered lactone ring, originally isolated from the fermentation broth of a japanese soil sample that contained the bacteria streptomyces tsukubaensis.