Tamoxifen Citrate 54965-24-1 Nolvadex CAS NO.54965-24-1

quick details:

tamoxifen citrate (nolvadex )

synonyms:1-p-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene citrate;(z)-2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethanamine,citrate(1:;(z)-2-(para-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethylaminecitrate(;2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethyl-ethanamin(z)-ethanamin2-hydrox;ici46,474;kessar;noltam;tamofen
cas:54965-24-1
mf: c32h37no8
mw:563.64
einecs: 259-415-2
mp:140-144 °c
storage temp. :2-8°c
water solubility:slightly soluble
chemical properties:white to off-white powder
biological activity:estrogen receptor antagonist/partial agonist. selective and potent inhibitor of mammalian sterol isomerase. neuroprotective in female rats in vivo . also high affinity agonist at the membrane estrogen receptor gpr30.
uses :for the treatment of advanced and recurrent breast cancer and ovarian cancer, etc.

tamoxifen citrate (nolvadex ) application

1). treatment of breast cancer.

2). prevention of breast cancer.

3). anti-tumor and anti-multidrug resistance.

by reducing membrane negotiability and enhancing rigidity of inter-cell binding site, tamoxifen citrate can reduce concentration and activity of cancer metastasis promoter and various activating enzymes, so as to inhibit or hinder growth and metastasis of cancer cell. in addition, it can promote cells surrounding tumor focus to secrete a negative growth factor - transforming growth factor tgf- g, inhibiting multiply indefinitely of cancer cells; inhibiting oxidative damage of dna bases which is caused by hydrogen peroxide generated from human neutrophils. so except for breast cancer, it is good for treatment and prevention of other malignant neoplasms, and is used for treatment of brain tumors, liver cancer, prostate cancer, etc. in addition, tamoxifen citrate can reduce release effect of membrane p170 glycoprotein through reducing membrane negotiability, improving intracellular effective concentration of cytotoxic drug and reducing drug resistance.

4). heart protection.

mechanism of action

tct has cis-trans isomers, whose cis isomer shows a weak estrogenic effect, while the trans isomer has an anti-estrogenic effect. when early application of tamoxifen or existence of low concentration, it binds to the estrogen receptor (er) in cytoplasm, showing a weak estrogenic effect. after tct entering into cell nucleus, it can inhibit transcription and synthesis of nuclear er, generating a lasting anti-estrogen effect. the study found that many new features of tct were related to the mechanism of action which was beyond its competitive estrogen receptors - membrane regulating mechanisms. tct as the membrane modifier, can reduce cell circulation. on this basis, tct can also serve as an antioxidant to protect cell membranes and human ldl from happening oxidative damage.

tamoxifen citrate (nolvadex ) coa

the quality control process:

1) producing
a)each operator must do self-inspection of producs and make the corresponding inspection records.
b)full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.

2) inspection
random sample, sample pretreatment, measuring and data processing.

3) before selling
test result can be provided before selling.only good quality goods will be into stock.
third-party detection institution is allowed if you are not satisfied with test results.

how to make an order :

1. name what your need ( which product , quantity )
2. full payment would be done once we come to an agreement on all details .
3. parcel would be shipped out upon receipt of payment .
4. info about parcel would be offered ( photo , tracking number )
5. finally you would get the parcel in 3~7 days .

payment and shipping:




our service:

1.we have experience in exporting pharmaceutical intermediates .
2.professional packing with professional materials
3. we have products in stock, and we will deliver them soon when your po arrived. meanwhile we will give you the tracking number in order to make you know the exact location of the products. we will keep track of the product until they arrive you; we choose the best courier service for you, and with the delivery around 5-7 working days.
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