Top Quality Antineoplastic Powder 99% CAS 149647-78-9 Vorinostat with Fast Delivery CAS NO.149647-78-9

vorinostat properties and safety information

melting point 161-162°c
density 1.2
rtecs rg8835000
storage temp. -20°c freezer
solubility dmso: ≥15mg/ml
hazard codes t
risk statements 61-68
safety statements 53-36/37-45
hs code 29280000

what is vorinostat

vorinostat is the first drug in a new class of anti-cancer agents that inhibit histone deacetylases (hdac). it was launched as an oral treatment for cutaneous manifestations in patients with cutaneous t-cell lymphoma (ctcl) who have progressive, persistent, or recurrent disease on or following two systemic therapies. hdacs are enzymes that catalyze the removal of the acetyl modification on lysine residues of proteins, including the core nucleosomal histones. together with their counterpart histone acetyltransferases (hats), hdacs regulate the acetylation level of the histones, which plays an important role in the regulation of chromatin plasticity and gene transcription. hypoacetylation of histones is associated with a condensed chromatin structure resulting in the repression of gene transcription, whereas acetylated histones are associated with a more open chromatin structure and activation of transcription. in some cancer cells, there is an overexpression of hdacs, resulting in hypoacetylation of histones. inhibitors of hdac are thought to transcriptionally reactivate dormant tumor-suppressor genes by allowing for the accumulation of acetyl groups on histones and an open chromatin structure. vorinostat inhibits the enzymatic activity of hdac1, hdac2, hdac3, and hdac6 at nanomolar concentrations (ic50 <86 nm). in vitro, it induces growth arrest, differentiation or apoptosis in a variety of tumor cells. in addition, vorinostat inhibits tumor growth in animal models bearing solid tumors, including breast, prostate, lung and gastric cancers, as well as hematologic malignancies such as multiple myeloma and leukemias.

q: what's your moq
a: for the high value product, our moq starts from 1g and generally starts from 10gs. for other low, price product, our moq starts from 100g and 1kg.

q: is there a discount
a: yes, for larger quantity, we always support with better price.

q: how to confirm the product quality before placing orders
a: you can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. you can send us your product specifications and requests, we will manufacture the products according to your requests

q: how to start orders or make payments
a: you can send our your purchase order (if your company has), or just send a simple confirmation by email or by trade manager, and we will send you proforma invoice with our bank details for your confirmation, then you can make payment accordingly.

q: how do you treat quality complaint
first of all, our quality control will reduce the quality problem to near zero. if there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.