Topotecan 123948-87-8 CAS NO.123948-87-8

Min.Order Quantity:: 100 Kilogram

Purity:: 99%

Port:: China Main Port

Payment Terms:: L/C,D/A,D/P,T/T,MoneyGram,Other

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Product Details

Keywords

RARECHEM AH PB 0251
123948-87-8
C23H23N3O5

Quick Details

ProName: Topotecan 123948-87-8
CasNo: 123948-87-8
Molecular Formula: C23H23N3O5
Appearance: powder
Application: 123948-87-8
DeliveryTime: Within 3-7 days
PackAge: Depended
Port: China Main Port
ProductionCapacity: 300 Kilogram/Month
Purity: 99%
Storage: Refrigerator
Transportation: by air or by sea
LimitNum: 100 Kilogram
Valid Period: 6 month
Application: Multipurpose intermediate
Application: ISO/9001 Certificate

Superiority

topotecan basic information

camptothecin anticancer drugs application production methods

product name:	topotecan
synonyms:	hycamptamine;hydrogen chloride, butanol reagent;hydrogen chloride gas;hydrogen chloride, methanol reagent;hydrogen chloride, methanol reagent 10;hydrogen chloride, methanol reagent 5;hydrochloric acid,1.1m;hydrochloric acid, 1n
cas:	123948-87-8
mf:	c23h23n3o5
mw:	421.45
einecs:	231-595-7
product categories:	apis;api
mol file:	123948-87-8.mol

topotecan chemical properties

mp	−114 °c(lit.)
bp	>100 °c(lit.)
density	1.2 g/ml at 25 °c(lit.)
vapor density	1.3 (vs air)
vapor pressure	613 psi ( 21.1 °c)
fp	12 °c
storage temp.	2-8°c
solubility	h₂o: soluble
form	liquid
cas database reference	123948-87-8(cas database reference)

safety information

hazard codes	t,c,f,xi
risk statements	36/37/38-67-35-20-11-34-48-46-36
safety statements	26-45-36/37/39-37/39-36-22-24/25-16-7
ridadr	un 3286 3/pg 2
wgk germany	2
rtecs	mw4025000
f	3
hazardclass	8
packinggroup	ii

msds information

provider	language
sigmaaldrich	english
alfa	english

topotecan usage and synthesis

camptothecin anticancer drugs	camptothecin anticancer drugs are alkaloids or derivatives of them after the structure transformation raised from deciduous plant davidia involucrata camptotheca acuminate seed or root bark. clinical application of them mainly includes camptothecin,hydroxycamptothecin, topotecan and irinotecan. topotecan is a water-soluble semi-synthetic derivative of camptothecin,it is a topoisomerase i inhibitor, inhibiting dna single strand dna scission reconnect to damage dna, its cytotoxicity occurs in cancer cell division s phase, it is an s phase cell cycle specific drug . in vivo it is a two-compartment model,it can be quickly distributed to the liver, kidneys and other parts , of a single intravenous infusion 1.5mg / m2 every 30 minutes , t1 / 2αis 4.1 to 8.1 minutes, plasma protein binding rate is 6.6% ~ 21.3%,it can go into the cerebrospinal fluid. most of it is excreted by the kidneys, a small part of it is excreted by the bile, within 12 hours, 90% of it is excreted.clearance rate of renal dysfunction decreases.it is clinically used for the treatment of small cell lung cancer (sclc), and advanced ovarian cancer, because it can penetrate the blood-brain barrier ,it has a certain effect on the central nervous system cancer and brain metastases. usage: every single drug dose 1.2mg / m2 intravenous infusion once a day, once every 5 days, 21 days is 1 cycle, there is the need to reduce the dose when in combination with other anticancer drugs. the main adverse events are hematologic toxicity, white blood cells, platelets and hemoglobin decrease; non-hematologic toxicity adverse events are loss of appetite, nausea, vomiting, hair loss, stomatitis, diarrhea, headache, fever, constipation, transient elevated transaminase; occasionally breathing difficulties, hematuria, andelectrocardiogram abnormalities. severe bone marrow suppression are hanged. monitor the blood and adjust the dose in accordance with changes in blood during the treatment , if necessary, granulocyte colony stimulating factor (g-csf), and transfusion of blood components may be given . the above information is edited by the chemicalbook of tian ye.
application	anti-cancer drugs.it can be used alone for the treatment of initially or continuously ineffective chemotherapy metastatic ovarian cancer.
production methods	compound (i) with 37% formaldehyde and 40% dimethylamine,after aminomethylation in acetic acid, produces the product.
chemical properties	off-white cryst
usage	antineoplastic;dna topoisomerase type 1 inhibitor

service we provide:

1. mixed container, we can mix different items in one container.

2. quality control, before shipment, free sample for test. after shipment, keep sample for 3 years

3. prompt shipment with professional documents

4. packing as your request, with photo before shipment

Details

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our laboratoy

we have our own independent lab test center：

this makes sure that our technology support is reliable and authoritative.all of self-owned fine chemicals are manufactured strictly in accordance with international standard.,and also has scientific cooperation with local colleges and institutes.