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1. 7-keto-dhea is a by-product of dehydroepiandrosterone (dhea) that is formed in the body. dhea is a "parent hormone" produced by glands near the kidneys.

2. 7-keto dhea is structurally practically identical to dhea, from which it is derived by an enzymatic conversion process taking place in the body. professor henry a. lardy and his team have researched 7-keto dhea for ten years at the institute of research on enzymes at the university of wisconsin. based on this research, professor lardy has obtained 9 patents for the uses of 7-keto dhea, for reinforcing and modulating the immune system, contributing to the treatment of alzheimer's disease and favoring weight loss.

3. the main worry of certain dhea disparagers is that it will partly convert itself into sex hormones and estrogens. this seems to be an obvious advantage for the healthy, looking to combat age-associated hormonal decline. unfortunately, this means advising all those with a personal or a family history of hormonal-dependent cancer risk (prostate, breast, ovarian) against taking dhea. this rules out the important part of the elderly, who would gain the most, from the benefit of supplementation. and some women badly support the side effects due to an increase of androgens which can be induced by dhea (acne, facial hair). for these, 7-keto dhea is the ideal solution. doses as high as 500 mg/kg have been administered to primates with no adverse effect being observed. this is equivalent to more than 100 times the recommended dose for a human being. a human toxicity study confirmed that in doses of 200 mg/day for 28 days, 7-keto dhea did not negatively affect biological blood and urine tests.

4. lardy has demonstrated that 7-keto dhea is around 2.5 times more powerful, milligramme for milligramme, than dhea, and this with no side effects. in fact, 7-keto dhea, metabolized in the body from dhea, may be responsible for most of the beneficial effects attributed to dhea. 7-keto dhea is more effective than dhea for improving memory, inducing thermogenesis and reinforcing or modulating the immune system.

5. 7-keto dhea is a hormone similar to its cousin dhea. proponents claim that it cannot be metabolized to active androgenic or estrogenic hormones but enhances the immune system, memory, and has thermogenic effects of its cousin. i find this hard to understand. the same mechanisms and biochemical pathways that lead to the benefits they claim also are involved in causing side effects. if 7 keto dhea has testosterone like benefits, it is likely that a number of side effects will occur due to androgen excess.

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