zafirlukast is a potent subtype specific cysteinyl leukotriene type 1 receptor (cyslt1) antagonist; antiasthmatic. the cysteinyl-
leukotrienes (cyslts), ltc4 and ltd4, are potent mediators of asthma and hypersensitivity. they induce bronchoconstriction,
augment microvascular permeability, and are vasoconstrictors of coronary arteries.
items |
specifications |
results |
||
appearance |
white or light yellow powder |
white powder |
||
solubility |
soluble in acetone,dmso,hf; in soluble in water, methanol |
complies |
||
identify 1 |
maximum absorption wavelength: 240nm,300nm |
239nm,298nm |
||
identify 2 |
content determination:conforms to spectrum |
complies |
||
identify 3 |
ir: conforms to spectrum |
complies |
||
chloride |
nmt 0.02% |
<0.02% |
||
sulfate |
nmt 0.04% |
<0.04% |
||
total impurities |
nmt 0.1% |
0.06% |
||
moisture |
nmt 1.0% |
0.38% |
||
loss on drying |
nmt 0.1% |
0.02% |
||
heavy metals |
nmt 20 ppm |
< 20 ppm |
||
content |
98.5%~101.5%( based on dry) |
99.9% |
||
conclusion |
conform to cp 2010 |