USD $5.00-10.00 / Gram
USD $1.00-10.00 / Kilogram
USD $5.00-10.00 / Gram
USD $2.00-10.00 / Kilogram
USD $2.00-10.00 / Kilogram
USD $5.00-10.00 / Gram
USD $8.20-8.80 / Kilogram
USD $1.00-10.00 / Kilogram
USD $1.00-10.00 / Kilogram
sorafenib tosylate is a novel multi-target anti-tumor drug developed by bayer pharmaceuticals, germany, which acts on both tumor cells and tumor blood vessels. it has a dual anti-tumor effect: it directly inhibits tumor cell proliferation by blocking the raf/mek/erk-mediated cell signaling pathway, and also inhibits vegf and platelet-derived growth factor (pdgf) receptors. blocking the formation of tumor neovascularization, indirectly inhibiting the growth of tumor cells.
product name | sorafenib tosylate |
cas | 475207-59-1 |
synonyms | sorafenib tosylate;sorafenib & its intermediates;sorafinib mesylate;4-methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-n-(5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide monomethanesulfonate;sorafenib tosylate(bay 43-9006,nexavar);2-pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-n-methyl-, 4-methylbenzenesulfonate;sorafenib tosylate (nexavar);sorafenib (nexavar) |
molecular formula | c28h24clf3n4o6s |
molecular weight | 637.0265696 |
mol file | 475207-59-1.mol |
appearance | white powder |
einecs number | 641-758-8 |
application | api |
used as a pharmaceutical intermediates.
it is used for the treatment of advanced liver cancer.
sorafenib tosylate (bay 43-9006, nexavar) is a small molecular inhibitor of vegfr, pdgfr, c-raf and b-raf with ic50s of 18 nm, 10 nm, 3 nm and 15 nm, respectively.
sorafenib tosylate (bay 43-9006) is a multikinase inhibitor of raf-1, b-raf and vegfr-2 with ic50 of 6 nm, 22 nm and 90 nm, respectively