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HENAN SUNLAKE ENTERPRISE CORPORATIONcas:118292-40-3 C21H21NO2S//file1.lookchem.com/cas/reactions/2021/07/02/8159145.png
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cas:118292-40-3 C21H21NO2S CAS NO.118292-40-3

Min.Order Quantity:
500 Gram
Purity:
99%
Port:
depend on clients require
Payment Terms:
L/C,D/A,D/P,T/T,Other

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Product Details

Keywords

  • C21H21NO2S
  • cas:118292-40-3 C21H21NO2S
  • cas:118292-40-3

Quick Details

  • ProName: cas:118292-40-3 C21H21NO2S
  • CasNo: 118292-40-3
  • Molecular Formula: C21H21NO2S
  • Appearance: white poweder
  • Application: C19H15BN2O2 CAS:952514-79-3 Boronic ac...
  • DeliveryTime: 3 wordking days after receive payment
  • PackAge: plastic woven bag or bucket
  • Port: depend on clients require
  • ProductionCapacity: 1 Kilogram/Day
  • Purity: 99%
  • Storage: under the cool and dry area
  • Transportation: by express or by sea
  • LimitNum: 500 Gram

Superiority

tazarotene basic information
dermatology drugs adverse reactions and precautions chemical properties
product name: tazarotene
synonyms: 3-pyridinecarboxylicacid,6-((3,4-dihydro-4,4-dimethyl-2h-1-benzothiopyran-6-y;agn190168;ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]pyridine-3-carboxylate;tazarotene;6-[2-(3,4-dihydro-4,4-dimethyl-2h-1-benzothiopyran-6-yl)ethynyl]- 3-pyridinecarboxylic acid ethyl ester;tazorac;zorac;6-[(3,4-dihydro-4,4-dimethyl-2h-1-benzothiopyran)-6-yl]nicotinic acid ethyl ester
cas: 118292-40-3
mf: c21h21no2s
mw: 351.46
einecs:
product categories: intermediates & fine chemicals;pharmaceuticals;retinoids;sulfur & selenium compounds;heterocycles;api;tazorac, avage, zora;inhibitors
mol file: 118292-40-3.mol
tazarotene structure
tazarotene chemical properties
mp 95-98°c
storage temp. store at +4°c
cas database reference 118292-40-3(cas database reference)
safety information
msds information
tazarotene usage and synthesis
dermatology drugs tazarotene belongs to the third generation retinoid dermatology drug and is also the retinoid a-like prototype for skin tropical administration and has regulatory effect on epidermal cell differentiation and proliferation. it is mainly used for the treatment of plaque psoriasis vulgaris. tazarotene cream can also be used for the treatment of facial acne. the clinical administrated product contains an active ingredient of this product being 15mg / 30g with its gel being subject to tropical administration. at half an hour before sleep every night, apply appropriate amount of this product into the wounded part. before treatment, first clean the affected area and apply the drug evenly to the skin lesion part after the dry of the skin for forming a thin film; after applying the drug, the patients should gently rub in order to promote the absorption of drugs. pea-sized gel can cover a palm-size area of ??skin lesions. the application area should not exceed 20% of body surface area. wash hands with soap after rubbing the drug.
psoriasis is a common benign, acute or chronic inflammatory skin disease. it occurred on the basis of genetic predisposition. trauma or irritation of normal skin can induce the occurrence of psoriasis lesions (koebner phenomenon): there are several different manifestations of psoriasis - the most common is plaque type. rash type (guttate) psoriasis includes a lot of 3 ~ 10mm skin lesions. it may occasionally occur after mental stress or streptococcal pharyngitis. seriously, there may be occasionally life-threatening forms such as generalized pustular and erythrodermic psoriasis. sudden onset of plaque type or generalized erythrodermic psoriasis may be associated with hiv infection.
tazarotene gel belongs to the topical formulations of formic acid and can be used for the treatment of psoriasis. early research has shown that: twice daily for topical administration of eight weeks with about 50% patients with mild to moderate psoriasis having at least 75% of their lesions be alleviated. but the completely eliminated plaque number accounts for less than 10%. tazarotene gel accounts for concentrations of 0.05% and 0.1%. there is no difference on the efficacy of topical administration of 0.1% gel once per day or twice per day. however, tropical administration of the 0.5% gel once per day gives a poor efficacy.
tazarotene, as a synthetic ethylene retinal, after topical application, it can be quickly converted to tazarotene acid and plays the pharmacological effects. tazarotene acid, after binding to the skin retinoid acid receptor -γ (rar-γ), it can achieve the purpose of alleviating the clinical symptoms through restoring to normal skin differentiation and reducing the inflammation of the skin.
adverse reactions and precautions adverse reactions of tazarotene mainly include skin reactions, manifested as itching, burning, stinging, redness, irritation, skin irritation, scaling, dermatitis, chapped, edema, bleaching, drying and bleeding.
precautions:
1. for women of childbearing age, within the first 2 weeks before the start of tazarotene gel treatment, we need to perform serum or urine pregnancy test to confirm that the pregnancy test is negative. start the treatment at the secondary day or third day in the next normal menstrual cycle. before treatment, during treatment and for some time after cessation of treatment, the patients must use effective contraceptive methods.
2. avoid contact between drug and eyes, mouth and mucous membrane; try to avoid the contact between skin and the drug. in case of contact with eyes, rinse thoroughly with water.
3. in cases of skin irritation such as itching, try not to scratch and can apply with a small amount of emollient; in severe case, you should stop using this drug or administer at the next day.
4. this product is not recommended for treating acute eczema.
5. during the treatment, avoid excessive exposure to the sun. you should also avoid simultaneously administration of taking photosensitive drug.
6. after application of the drug, avoid using clothing and bandaging for affected area. you should avoid using pharmaceuticals and cosmetics which can dry the skin. safety information regarding to the applied area should not exceed 20% of the body surface area has not been established.
7. it should be contraindicated in pregnant and lactating women. for this drug, patients allergic to other aldehydes retinol or vitamin a derivative should be tabooed.
8. safety and efficacy regarding to the children under age 12 for using tazarotene has not been established.
the above information is edited by the chemicalbook of dai xiongfeng.
chemical properties it is as white-like or pale yellow solid.
chemical properties white solid
usage an acetylenic retinoid prodrug converted to the active metabolite, tazarotenic acid, with selective affinity for retinoic acid receptors rar and rar. antiacne; antipsoriatic. used in treatment of photodamaged skin
usage an acetylenic retinoid prodrug converted to the active metabolite, tazarotenic acid, with selective affinity for retinoic acid receptors rarβ and rarγ. antiacne; antipsoriatic. used in treatment of photodamaged skin.
usage tazarotene is a prescription topical retinoid sold as a cream or gel. this medication is approved for treatment of psoriasis, acne, and sun damaged skin (photodamage). it is commonly sold in two concentrations: 0.05% and 0.1%. in addition to tretinoin, wh
usage anticholelithic
usage used to treat psoriasis, acne and sun damaged skin.

our services

1. certificate of analysis (coa)

2. material safety data sheet (msds)

3. route of synthesis (ros)

4. method of aanlysis (moa)

5. nuclear magnetic resonance (nmr)

6. packing pictures and loading video before loading

7. free sample

9. factory audit

10. strong after-sale service

advantages

· government supports, which guarantees better company credibility and finance safe.

· fully free sample. finerchem is confident at the quality of the products, it is gald to supply samples for final customers.

· factory is in national new materials industry park where guarantees safe and international standard production environment. welcome to visit our factory.

· more than 10 years chemical products exported experience, and good relationship with customs and shipment agents, it is easy for us to clear customs and arrange delivery by sea, air and courier.

· professional r&d technology and equipments which keep products quality better and better.

Details

tazarotene basic information
dermatology drugs adverse reactions and precautions chemical properties
product name: tazarotene
synonyms: 3-pyridinecarboxylicacid,6-((3,4-dihydro-4,4-dimethyl-2h-1-benzothiopyran-6-y;agn190168;ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]pyridine-3-carboxylate;tazarotene;6-[2-(3,4-dihydro-4,4-dimethyl-2h-1-benzothiopyran-6-yl)ethynyl]- 3-pyridinecarboxylic acid ethyl ester;tazorac;zorac;6-[(3,4-dihydro-4,4-dimethyl-2h-1-benzothiopyran)-6-yl]nicotinic acid ethyl ester
cas: 118292-40-3
mf: c21h21no2s
mw: 351.46
einecs:
product categories: intermediates & fine chemicals;pharmaceuticals;retinoids;sulfur & selenium compounds;heterocycles;api;tazorac, avage, zora;inhibitors
mol file: 118292-40-3.mol
tazarotene structure
tazarotene chemical properties
mp 95-98°c
storage temp. store at +4°c
cas database reference 118292-40-3(cas database reference)
safety information
msds information
tazarotene usage and synthesis
dermatology drugs tazarotene belongs to the third generation retinoid dermatology drug and is also the retinoid a-like prototype for skin tropical administration and has regulatory effect on epidermal cell differentiation and proliferation. it is mainly used for the treatment of plaque psoriasis vulgaris. tazarotene cream can also be used for the treatment of facial acne. the clinical administrated product contains an active ingredient of this product being 15mg / 30g with its gel being subject to tropical administration. at half an hour before sleep every night, apply appropriate amount of this product into the wounded part. before treatment, first clean the affected area and apply the drug evenly to the skin lesion part after the dry of the skin for forming a thin film; after applying the drug, the patients should gently rub in order to promote the absorption of drugs. pea-sized gel can cover a palm-size area of ??skin lesions. the application area should not exceed 20% of body surface area. wash hands with soap after rubbing the drug.
psoriasis is a common benign, acute or chronic inflammatory skin disease. it occurred on the basis of genetic predisposition. trauma or irritation of normal skin can induce the occurrence of psoriasis lesions (koebner phenomenon): there are several different manifestations of psoriasis - the most common is plaque type. rash type (guttate) psoriasis includes a lot of 3 ~ 10mm skin lesions. it may occasionally occur after mental stress or streptococcal pharyngitis. seriously, there may be occasionally life-threatening forms such as generalized pustular and erythrodermic psoriasis. sudden onset of plaque type or generalized erythrodermic psoriasis may be associated with hiv infection.
tazarotene gel belongs to the topical formulations of formic acid and can be used for the treatment of psoriasis. early research has shown that: twice daily for topical administration of eight weeks with about 50% patients with mild to moderate psoriasis having at least 75% of their lesions be alleviated. but the completely eliminated plaque number accounts for less than 10%. tazarotene gel accounts for concentrations of 0.05% and 0.1%. there is no difference on the efficacy of topical administration of 0.1% gel once per day or twice per day. however, tropical administration of the 0.5% gel once per day gives a poor efficacy.
tazarotene, as a synthetic ethylene retinal, after topical application, it can be quickly converted to tazarotene acid and plays the pharmacological effects. tazarotene acid, after binding to the skin retinoid acid receptor -γ (rar-γ), it can achieve the purpose of alleviating the clinical symptoms through restoring to normal skin differentiation and reducing the inflammation of the skin.
adverse reactions and precautions adverse reactions of tazarotene mainly include skin reactions, manifested as itching, burning, stinging, redness, irritation, skin irritation, scaling, dermatitis, chapped, edema, bleaching, drying and bleeding.
precautions:
1. for women of childbearing age, within the first 2 weeks before the start of tazarotene gel treatment, we need to perform serum or urine pregnancy test to confirm that the pregnancy test is negative. start the treatment at the secondary day or third day in the next normal menstrual cycle. before treatment, during treatment and for some time after cessation of treatment, the patients must use effective contraceptive methods.
2. avoid contact between drug and eyes, mouth and mucous membrane; try to avoid the contact between skin and the drug. in case of contact with eyes, rinse thoroughly with water.
3. in cases of skin irritation such as itching, try not to scratch and can apply with a small amount of emollient; in severe case, you should stop using this drug or administer at the next day.
4. this product is not recommended for treating acute eczema.
5. during the treatment, avoid excessive exposure to the sun. you should also avoid simultaneously administration of taking photosensitive drug.
6. after application of the drug, avoid using clothing and bandaging for affected area. you should avoid using pharmaceuticals and cosmetics which can dry the skin. safety information regarding to the applied area should not exceed 20% of the body surface area has not been established.
7. it should be contraindicated in pregnant and lactating women. for this drug, patients allergic to other aldehydes retinol or vitamin a derivative should be tabooed.
8. safety and efficacy regarding to the children under age 12 for using tazarotene has not been established.
the above information is edited by the chemicalbook of dai xiongfeng.
chemical properties it is as white-like or pale yellow solid.
chemical properties white solid
usage an acetylenic retinoid prodrug converted to the active metabolite, tazarotenic acid, with selective affinity for retinoic acid receptors rar and rar. antiacne; antipsoriatic. used in treatment of photodamaged skin
usage an acetylenic retinoid prodrug converted to the active metabolite, tazarotenic acid, with selective affinity for retinoic acid receptors rarβ and rarγ. antiacne; antipsoriatic. used in treatment of photodamaged skin.
usage tazarotene is a prescription topical retinoid sold as a cream or gel. this medication is approved for treatment of psoriasis, acne, and sun damaged skin (photodamage). it is commonly sold in two concentrations: 0.05% and 0.1%. in addition to tretinoin, wh
usage anticholelithic
usage used to treat psoriasis, acne and sun damaged skin.

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