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Career Henan Chemical Cocompetitive price Phenylhydrazine 100-63-0//www.lookchem.com/300w//2010/0612/100-63-0.jpg

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competitive price Phenylhydrazine 100-63-0 CAS NO.100-63-0

Min.Order Quantity:
1 Kilogram
Purity:
97%-99%
Port:
Shanghai/Qingdao
Payment Terms:
T/T,Western Union,Other

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Product Details

Keywords

  • 100-63-0
  • Phenylhydrazine
  • C6H8N2

Quick Details

  • ProName: competitive price Phenylhydrazine 100-...
  • CasNo: 100-63-0
  • Molecular Formula: C6H8N2
  • Appearance: Liquid
  • Application: It is an important raw material
  • DeliveryTime: within 3 days
  • PackAge: as customer's request
  • Port: Shanghai/Qingdao
  • ProductionCapacity: 1 Kilogram/Day
  • Purity: 97%-99%
  • Storage: Store at RT.
  • Transportation: By sea/car
  • LimitNum: 1 Kilogram

Superiority

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
Our R&D center building area is 811 square meters, with 3 contributing proffesor of technical advisor, 4 Dr., 10 masters, and 28 research staff. Our level of chemical synthesis is known to the industry. So we have accumulated rich experience in synthetic methods design and exploring the synthesis of new technology. Not only we are good in heterocyclic chemistry, chiral chemistry (asymmetric synthesis and enzyme reactions), metal organic synthesis, high throughput chemistry, also specializes in bioorganic chemistry, including nucleosides, nucleotides, sugar chemistry, peptide chemistry. R & D center has many sets of 10 liters, 20 liters, 50 liters, 100L multifunction high and low pressure reaction still, rotary evaporator, anhydrous anaerobic reaction devices, hydrogenation equipment, cryogenic process (-120 degrees) equipment, to complete mg level custom synthesis and kg level process development experiments. The Existing 600M NMR, LCMS, Fourier Infrared Spectrometer, liquid chromatography, differentialscanning calorimetry, and other advanced detection equipment areto ensure quality and efficient completion of R&D projects. So far our completed custom synthesis products is more than 5300 species, where dozens of them are non-CAS declaration products, almost including all types of organic reactions.
At present, in addition to our headquarters in Zhengzhou, we also have another product base in Jun County, Henan Province. This base is the attracting investment of science and technology project of Jun County govenment’s, which covers 6529 square meters. In addition to bear our own company’s 1000L-5000L pilot task, also bear the function of Henan pilot incubation service platform, In order to improve Henan and surroundings’ synthetic reaction pilot service ability and the key technology development capabilities. Base with three GMP standards workshop, a testing center, one test center,one experiment center and associatd supporting facilities, can carry out oxidation, hydrogenation (70 kg pressure), halogenated, acieration, etherification, condensation, cyclization, formatting, ammoniated, diazotization andpilot service such as azide reactions etc. In the future we will work hard to make it become the most complete production system in central China and even the whole country, the highest technical level, the strongest talent team, the most popular service scope of pilot incubation service platform.
Henan Coreychem co., LTD. is committed to provide cost effective chemical service to the global fine chemical industry product development agencies; we adhering to the consistent good commercial reputation, to create a highly efficient, high quality of chemical research, development, production, sales and service of integrated platform, let our customers faster, better get ideal and thoughtful service.
Coreychem
Henan CoreyChem Co., Ltd, facing global High-tech pharmaceutical raw materials, high value-added new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade.
Innovative
Henan Coreychem is committed to continuously explore new compound synthesis technology in recent years,we were on enzyme catalysis, catalytic metal complexes in the total synthesis was tested and achieved good results: S.lycopersicum (+) - Aszonalenin (+) - Citrinadin B Total Synthesis of ( − )-Brevicompanine B by Ir-Catalyzed Total Synthesis of (+)-Citrinadin B

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.

Details

Phenylhydrazine Chemical Properties
Melting point 19 °C
Boiling point 238-241 °C(lit.)
density 1.099 g/mL at 25 °C(lit.)
vapor density 4.3 (vs air)
vapor pressure <0.1 mm Hg ( 20 °C)
refractive index n20/D 1.607(lit.)
Fp 192 °F
storage temp. Store at RT.
solubility Soluble in dilute acids.
form Powder
pka 8.79(at 15℃)
color White to slightly blue or light beige
explosive limit 1.1%(V)
Water Solubility 145 g/L (20 ºC)
Sensitive Air & Light Sensitive
Merck 14,7293
BRN 606080
Exposure limits TLV-TWA skin 0.1 ppm (0.44 mg/m3) (ACGIH), 5 ppm (22 mg/m3) (OSHA); STEL 10 ppm (44 mg/m3) (OSHA); carcinogenicity: A2-Suspected Human Carcinogen (ACGIH), Carcinogen (NIOSH). .
Stability: Stable, but may decompose in sunlight. May be air or light sensitive. Incompatible with strong oxidizing agents, metal oxides.
CAS DataBase Reference 100-63-0(CAS DataBase Reference)
NIST Chemistry Reference Hydrazine, phenyl-(100-63-0)
EPA Substance Registry System Hydrazine, phenyl-(100-63-0)
Safety Information
Hazard Codes T,N
Risk Statements 45-23/24/25-36/38-43-48/23/24/25-50-68
Safety Statements 53-45-61
RIDADR UN 2572 6.1/PG 2
WGK Germany 3
RTECS MV8925000
F 8-10-23
Autoignition Temperature 345 °F
TSCA Yes
HS Code 2928 00 90
HazardClass 6.1
PackingGroup II
Hazardous Substances Data 100-63-0(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 188 mg/kg
MSDS Information
Provider Language
SigmaAldrich English
ACROS English
ALFA English
Phenylhydrazine Usage And Synthesis
Hydrazine derivative Phenylhydrazine is also known as the hydrazinobenzene. It was first successfully synthesized by the German organic chemist Hermann-Emil-Fischer in 1875 and is the first synthesized hydrazine derivatives. At room temperature, it is a pale yellow crystalline or oily liquid while at low temperature it appears as monoclinic prismatic crystals. It can be easily subject to oxidization in the air and exhibit dark brown or dark red. It is one of the hydrazine derivatives and is often abbreviated as PhNHNH2. It is slightly soluble in water and alkali solution and can be dissolved in dilute acid. It is miscible with ethanol, ethyl ether, chloroform and benzene. Common method of its preparation is through the reaction between aniline and sodium nitrite under the action of hydrochloric acid for generation of diazonium salt which is then reduced by sulfite/sodium reduction for obtaining it. Acid precipitation can generate phenylhydrazine hydrochloride with neutralization generating phenylhydrazine. It can be applied to making dyes, drugs, and being used as developer. It is also an important reagent for identification of carbonyl group and can be used for identifying aldehydes, ketones and carbohydrates. It can react with benzaldehyde to generate phenylhydrazine. We can use the hydrazone generated through phenylhydrazine or 2, 4-dinitrophenylhydrazine to identify aldehydes and ketones, It can trigger Fischer indole synthesis upon reaction with aldehydes and ketones (first found by the Emil Hermann Fischer in 1883, the reaction is using phenylhydrazine and aldehyde, ketone for heating and rearrangement under acid-catalysis for the elimination of one molecule of ammonia to give 2-or 3-substituted indole.) to give indole ring-class compound.
Hermann-Emil-Fischer Fischer is a German organic chemist. He used phenylhydrazine to react with carbohydrate and generate hydrazone and osazone and form a crystalline compound which is easy for purification. Then it is decomposed into pure sugar. This is a powerful means for studying carbohydrate structures and synthesis of a variety of sugars and enables the theoretic clarification of the structure of glucose and summarizing of the general stereoisomerism phenomenon of saccharides and further using of Fischer projection for describing it. He has also demonstrated that the caffeine, theophylline, uric acid all belongs to purine derivatives and also had successfully synthesized purine. He also had opened up the study of proteins and had demonstrated that amino acids forms polypeptide via peptide bond and successfully synthesized polypeptides. In 1902, Fischer, because of the synthesis of purine and carbohydrate, was awarded for the Nobel Prize in Chemistry.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
Phenylhydrazine: preparation and application Phenylhydrazine is the first synthetic hydrazine derivatives which can often be used as intermediates of organic dyes, pharmaceuticals and pesticide. It can also be used as organic intermediates for synthesis of pyrazoline, triazole, and indole; It can also be used as dye intermediates like disazo dye intermediates such as 1-phenyl-3-methyl-5-pyrazolone and so on; It can also be used as pharmaceutical intermediates for preparation of antipyretic, analgesic, anti-inflammatory drugs such as antipyrine and aminopyrine, etc; it can also be used as photography drugs (photosensitive dye); phenylhydrazine is also the raw material for the production of pesticides "imputed phosphorus"; phenylhydrazine is also an important kind of carbonyl group identification reagents used for identifying aldehydes, ketones and carbohydrates.
Phenylhydrazine is toxic. After inhalation, due to hemolysis, it can cause anemia and headache and can even cause jaundice in severe cases. It can also have stimulating effect on the eyes such as causing corneal disorders. Rat-oral LD50:188 mg/kg. Workplace: maximum allowable concentration: 0.44mg/m3.
Lab often uses aniline as raw materials for reaction with sodium nitrite in hydrochloric acid for generating diazonium salt and then reacted with sulfur dioxide and sulfurous acid for reduction to produce phenylhydrazine sodium sulfonate and further salting via hydrochloric acid to form phenylhydrazine hydrochloride. After neutralization and deacidification, we can obtain phenylhydrazine.

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