Afine Chemicals Limited
Country: China (Mainland)
Year Established: 2005
Business License:
Business type: Lab/Research institutions
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good supplier 90357-06-5 Bicalutamide Hot sale with fast delivery CAS NO.90357-06-5

Min.Order Quantity:: 1 Kilogram

Purity:: 99%min

Port:: Shanghai or Hangzhou or Beijing etc

Payment Terms:: L/C,D/A,D/P,T/T,

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Product Details

Keywords

Bicalutamide good supplier
90357-06-5 with fast delivery
Hot sale 90357-06-5

Quick Details

ProName: good supplier 90357-06-5 Bicalutamide...
CasNo: 90357-06-5
Molecular Formula: C18H14F4N2O4S
Appearance: white to off white powder
Application: Pharmaceutical active ingredients Pha...
DeliveryTime: Usually One week
PackAge: According to regular packing:bottle,Fo...
Port: Shanghai or Hangzhou or Beijing etc
ProductionCapacity: 1-100 Kilogram/Month
Purity: 99%min
Storage: Shall be stored it in a dry and cool a...
Transportation: ocean shipping or air transportation
LimitNum: 1 Kilogram
Related Substances: Effective ingredients >99%
Residue on Ignition: 0.1
Heavy Metal: 0
Valid Period: 3 year
COA&Document: Please send us inquiry

Superiority

good supplier 90357-06-5 bicalutamide hot sale with fast delivery

1. new molecules r&d

2. own test center hplc nmr gc lc-ms

3. api and intermediates from china reputed manufacturers

4. documents support coa moa msds dmf open part

our advantages

1. government awarded company. top 100 enterprises in hangzhou

2. quality warrant. if any quality failure. we 100% return the payment or replacement

3.more than 14 years experiences in pharmaceutical and chemical international trading

4.fast response on customers request and fast shipment

bicalutamide basic information

bicalutamide solubility determination of the content of bicalutamide tablets by high performance liquid chromatography (hplc) bicalutamide tablets adverse reaction chemical properties uses producing method

product name:	bicalutamide
synonyms:	(+-)--2-hydroxy-2-methyl;propanamide,n-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl);ici-176334;casodex;bicalutamide;n-[(4-cyano-3-trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide;n-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropionanilide;bicalutamide (subject to patent free)
cas:	90357-06-5
mf:	c18h14f4n2o4s
mw:	430.3733728
einecs:
product categories:	api;modrastane;active pharmaceutical ingredients;antiandrogen;antineoplastic (hormonal);anti-neoplastic;-;aromatics;intermediates & fine chemicals;pharmaceuticals;sulfur & selenium compounds;api's
mol file:	90357-06-5.mol

bicalutamide usage and synthesis

bicalutamide solubility soluble in dimethyl formamide; dissolved in tetrahydrofuran; slightly soluble in ethyl acetate and methanol; insoluble in water.

determination of the content of bicalutamide tablets by high performance liquid chromatography (hplc) using shimadzu clc-ods (150mm´6.0mm, 5μ) column. 0.1% potassium dihydrogen phosphate solution-acetonitrile (50:50) as the mobile phase, detecting at 272nm wavelength. result: bicalutamide had a good linear relationship (r=0.9995) when the concentration in the range of 0.05mg*ml-1~0.20mg*ml-1. the average recovery was 99.5%, and rsd=0.9% (n=9 ) conclusion: the method is simple, good accuracy and high precision.

bicalutamide tablets bicalutamide tablet is a non-steroidal androgen antagonist, which competes androgen receptor with the androgen, blocks cellular uptake of androgen, and inhibits the binding of androgens to the target organ. it binds with the androgen receptor that forms receptor complex, which enters the nucleus and combined with the nucleoprotein, consequently inhibiting tumor cell growth. it can be as a first-line drug for palliative treatment of advanced prostate cancer.

dosage and administration:

adult: adult males including the elderly: one (50mg), once a day. the treatment should be started simultaneously with lhrh analogue therapy or surgical orchiectomy.

children: this product is contraindicated in children.

renal impairment: the patients with renal impairment don’t need dose adjustment.

hepatic impairment: the patients with mild liver damage don’t need dose adjustment, while the patients with severe liver damage may occur drug accumulation (see precautions).

precautions:

this product is widely metabolized in the liver. data show that patients with severe liver damage may slow down drug clearance, which may lead to accumulation. so the patients with moderate and severe liver injury should use it with caution.

the patients may appear liver changes by using it, so it should be considered regular liver function tests. the main changes generally appear within the first 6 months of treatment using this product.

severe changes in liver function are rarely visible in the treatment of the product (see adverse reactions). if there is a serious change in treatment using this product, it should be discontinued.

this product is shown to inhibit the activity of cytochrome p450 (cyp3a4). when combined with drugs metabolised mainly by cyp3a4, the patients should be caution (see contraindications and drug interactions).

pregnancy and lactation: this product is contraindicated in women, especially for pregnant women or nursing mothers.

effect on driving and operating machinery ability: this product does not affect the ability of patients of driving and operating the machine.

the above information is edited by the chemicalbook of kui ming.

Details

packaging & shipping

powdered packaging: according to regular packing:bottle,foil bag ,tin , drum etc

company information

afine chemicals limited is specialized in the fine chemicals and pharmaceuticals and we have enjoyed great popularity in world markets. since 2005, we have been rapidly growing to a leading manufacturer and trader of apis in china.

now we own two independent business divisions: fine chemicals division and pharmaceutical division:

(1). fine chemical department: manufacturing and trading a variety of high-quality of optical brightener and textile auxiliary as well as dye stuff, pigments and other fine chemicals. now we are one of the leading exporters of optical brightener in china.

(2). pharmaceutical division: manufacturing, contract r&d, marketing and distribution of pharmaceutical active ingredients, intermediates and feed additives

innovation and good service are the secrets of our success and rapid growth. continuous innovation improves the quality of our products, and helps us launch new market-oriented products into the market. warm and efficient service guarantees the timely, professional and sincere service to our clients.

we are awarded the title of "top 100 innovation-oriented export enterprises of hangzhou in 2008" by hangzhou government among more than 13,000 competitors in march 2009. and we are doing our best to manage the best product and the most reasonable price. looking forward to establish businessship with you!

faq

1. what's your payment terms?
l/c d/a d/p t/t
2. what's your delivery time?
usually one week
3. how about the packing?
according to regular packing:bottle,foil bag ,tin , drum etc
4. when can i get reply?
will contact you as soon as possible in 24 hours one working day!
5. how about the validity of the products?
according to the products you ordered.
6. what documents you provide?
documents support coa moa msds dmf open part
7. what is loading port?
shanghai or hangzhou or beijing etc