hydrochlorothiazide CAS NO.58-93-5

productname:hydrochlorothiazide

cas:58-93-5

molecular formula:c7h8cln3o4s2

molecular weight:297.73900

physical character：the product is white or white like crystalline powder，odorless.

packing storage:25kg/drum

appearance:white or almost white like crystalline powder

loss or dry:≤0.5%

heavy metals：≤0.0015%

assay：98.0%-102.0%

brief introduction：hydrochlorothiazide (hctz, hct or hzt) is a diuretic. it is usually used to treat hypertension and edema caused by fluid accumulation. other uses include diabetes insipidus and tubular acidosis, which can also reduce hypercalciuria, thereby reducing the risk of kidney stones. in addition, the drug is often used as the first-line treatment of hypertension. hydrochlorothiazide is an oral drug, sometimes mixed with other antihypertensive drug to make compound tablets to enhance the efficacy. hydrochlorothiazide is classified as a thiazide drug, mainly by reducing the water retention function of the kidney. it will directly reduce blood volume, reduce the amount of blood flowing back to the heart and reduce the volume of cardiac output. long term use of hydrochlorothiazide can reduce peripheral vascular resistance. side effects of hydrochlorothiazide include decreased renal function, electrolyte imbalance (especially hypokalemia and, less commonly, hyponatremia), gout, hyperglycemia (hyperglycemia), and dizziness at the moment of standing up. according to the report, people who are allergic to hydrochlorothiazide often have an allergic constitution to sulfonamides, but there is not much evidence to support this argument. although hydrochlorothiazide is still available to pregnant women, it is not the first-line drug of choice. merck and ciba found hydrochlorothiazide at the same time and shared the patent of this drug at that time. in january 1959, the two companies listed the drug under different trade names. hydrochlorothiazide is listed in the list of essential drugs by the world health organization, which is the most important and essential drug in various medical systems. according to statistics, hydrochlorothiazide was the second most commonly used antihypertensive drug in the united states in 2008. the patent of hydrochlorothiazide has expired and belongs to the scientific name drug at present. and its price on the market is not high.