intermediate of LCZ696 CAS NO.149709-62-6

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hp90699 ahu-377 (sacubitril) 149709-62-6
ahu-377 (sacubitril) 149709-62-6
	mf c24h29no5 c4h11no3	msds:aviable
	mw 532.6	place of origin:china
	synonym: sacubitril
ahu-377 (sacubitril) description	ahu-377 (sacubitril) is a prodrug which is activated in vivo by hydrolytic enzyme esterases to form an active compound lbq657 that selectively and potently inhibits the enzyme neprilysin with ki at low nm. neprilysin is a protease responsible for the degradation of atrial and brain natriuretic peptides. inhibition of the enzyme prevents the degradation of natriuretic peptides and activates cgmp signaling pathways that regulate volume and blood pressure. ahu-377 (sacubitril) is an investigational antihypertensive drug being studied for use in combination with valsartan (molar ratio: 1:1) (our prod no. ct-vals). the combination drug, known as lcz696, is in clinical trials for the treatment of heart failure.
ahu-377 (sacubitril) structual
purity	99% min
ahu-377 (sacubitril) storage condition	store at 0°c (short term), -20°c (long term) desiccated
ahu-377 documents provide

enbridge pharmtech co., ltd. is an innovative company integrated with r&d, manufacturing, marketing and distribution of intermediates and fine chemicals, mainly used to pharmaceutical, pesticide, cosmetics, health care products and electronic chemicals. our core services also include custom synthesis and contract manufacturing services.
enbridge pharmtech has one r&d center and two manufacturing bases. r&d center is equipped with good organic synthesis and analytical instrumenets. in our two production bases, we have large-scale reactors which cover various ss/ glass lined reactors capable of conducting high pressure, high temperature and low temperature reactions. we have a large number of well-equiped instruments and have the production capability from kilogram to ton...pharma grade