top Fasudil hydrochloride CAS NO.105628-07-7

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Min.Order Quantity:: 1 Gram

Purity:: 99%

Port:: China main port

Payment Terms:: L/C,T/T,

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Product Details

Keywords

Fasudil hydrochloride
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Quick Details

ProName: top Fasudil hydrochloride
CasNo: 105628-07-7
Molecular Formula: C14H18ClN3O2S
Appearance: Colorless to light yellow liquid
Application: Used in a base-free iridium-catalyzed ...
DeliveryTime: With about 7-10 days after receipt the...
PackAge: as you requested
Port: China main port
ProductionCapacity: 10 Kilogram/Day
Purity: 99%
Storage: room temperature
Transportation: by courier
LimitNum: 1 Gram
Transportation: by courier

Superiority

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4.customs synthesis

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Details

product name:	fasudil hydrochloride
synonyms:	1-(5-isoquinolinesulfonyl)homopiperazine hydrochloride;(5-isoquinolinesulfonyl)homopiperazine, 2hcl;5-(1,4-diazepan-1-ylsulfonyl)isoquinoline hydrochloride;hexahydro-1-(5-isoquinolinylsulfonyl)-monohydrochloride;ha-1077;ha-1077 dihydrochloride;fasudel;fasudil dihydrochloride
cas:	105628-07-7
mf:	c14h18cln3o2s
mw:	327.83
einecs:
product categories:	apis;api;inhibitor;cardiovascular & blood system agents;inhibitors
mol file:	105628-07-7.mol

fasudil hydrochloride chemical properties

melting point	220.5°; mp 219.3° (shirotani)
solubility	h₂o: >200 mg/ml
form	solid
color	white
water solubility	soluble in water and dimethyl sulfoxide. insoluble in ethanol.
merck	14,3942
cas database reference	105628-07-7(cas database reference)

safety information

risk statements	22
safety statements	36-60
wgk germany	3
rtecs	hm4031166

msds information

provider	language
sigmaaldrich	english

fasudil hydrochloride usage and synthesis

indications and usage	fasudil hydrochloride is a new drug with a wide range of pharmacological effects, developed by asahi kasei corporation (japan.) it is a cardiovascular and cerebrovascular drug which improves symptoms of ischemic cerebrovascular disease such as cerebral vasospasm following subarachnoid hemorrhage. it has significant neuroprotective and therapeutic effects for ischemic cerebrovascular disease, and is suited for clinical use, particularly at the grassroots level to reduce mortality and improve quality of life.
mechanisms of action	fasudil hydrochloride is an isoquinoline sulfonamide derivative which can relax separated cerebral blood vessels, inhibit the shrinkage of separated blood vessels caused by calcium influx, inhibit different mechanisms of brain blood vessel contraction from contractile agents, and inhibit intracellular calcium ion activity without reducing calcium ion concentration. fasudil hydrochloride is an rho kinase inhibitor which dilates vessels, reduces tension of endothelial cells, and improves microcirculation of brain tissue without producing or exacerbating diversion of blood to the brain, by increasing activity of myosin light chain phosphatase. at the same time, it can protect nerves against apoptosis and promote their regeneration. fasudil hydrochloride promotes recovery of neural function and reduces clinical symptoms.
adverse reactions	adverse reactions after use can include intracranial hemorrhage, gastrointestinal bleeding, pulmonary hemorrhage, nasal bleeding, subcutaneous bleeding, and loss of consciousness, etc., as well as abnormal liver function. low blood pressure, anemia, leukopenia, renal dysfunction, polyuria, rashes, and fever, etc. occur occasionally.
warnings and precautions	patients with intracranial hemorrhage or possibility thereof, or low blood pressure, should not use. patients with diabetes mellitus, cerebral arterial sclerosis, severe disturbance of consciousness, subarachnoid hemorrhages with cerebrovascular disorders, and liver or kidney dysfunction, or those over 70 years old, pregnant, or children should use with caution. breastfeeding women should stop while using the drug. fasudil hydrochloride can only be administered via intravenous drip.
uses	vasodilator, potent rho-kinase inhibitor