USD $100.00-150.00 / Kilogram
USD $100.00-150.00 / Kilogram
1.certificate of analysis (coa)
2.material safety data sheet (msds)
3.route of synthesis (ros)
4.method of aanlysis(moa)
5.nuclear magnetic resonance(nmr)
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1. quality control, before shipment, free sample for test.
2. prompt shipment with professional documents
3. packing as your request, with photo before shipment
4. mixed containers with different mixed items in one container
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product name: | trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole |
synonyms: | trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole;asenapine;(3ar,12br)-rel-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole;1h-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, (3ar,12br)-rel-;1h-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, trans-;asenapine [inn:ban];einecs 265-829-4;unii-jkz19v908o |
cas: | 65576-45-6 |
mf: | c17h16clno |
mw: | 285.772 |
einecs: | 265-829-4 |
product categories: | aromatics;heterocycles;intermediates & fine chemicals;pharmaceuticals |
mol file: | 65576-45-6.mol |
trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole chemical properties |
density | 1.231 |
storage temp. | store at +4°c |
safety information |
trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole usage and synthesis |
chemical properties | yellow oil |
usage | combined serotonin (5ht2) and dopamine (d2) receptor antagonist; structurally related to mianserin. antipsychotic |
biological activity | novel psychopharmacologic agent. displays antagonist activity at 5-ht, dopamine, noradrenalin and histamine receptor subtypes (pk i values are 8.60, 8.40, 10.15, 9.75, 10.46, 8.84, 9.60, 9.94, 8.85, 8.90, 8.84, 9.38, 8.95, 8.93, 8.9, 9.49, 8.91, 9.00 and 8.21 for 5-ht 1a , 5-ht 1b , 5-ht 2a , 5-ht 2b , 5-ht 2c , 5-ht 5a , 5-ht 6 , 5-ht 7 , d 1 , d 2l , d 2s , d 3 , d 4 , α 1a , α 2a , α 2b , α 2c , h 1 and h 2 receptors respectively). displays no appreciable affinity for muscarinic receptors. exhibits potent activity in animal models predictive of antipsychotic efficacy. |
trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole preparation products and raw materials |