1.Identification
1.1 GHS Product identifier
| Product name | 1-Methoxy-2-propanol |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | propylene glycol methyl ether |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | For industry use only. Solvents |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
1.5 Emergency phone number
| Emergency phone number | - |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
2.Hazard identification
2.1 Classification of the substance or mixture
Flammable liquids, Category 3
Specific target organ toxicity – single exposure, Category 3
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |   |
|---|---|
| Signal word | Warning |
| Hazard statement(s) | H226 Flammable liquid and vapour H336 May cause drowsiness or dizziness |
| Precautionary statement(s) | |
| Prevention | P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. |
| Response | P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor/…if you feel unwell. |
| Storage | P403+P235 Store in a well-ventilated place. Keep cool. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to ... |
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 1-Methoxy-2-propanol | 1-Methoxy-2-propanol | 107-98-2 | none | 100% |
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
Fresh air, rest. Refer for medical attention.
In case of skin contact
Remove contaminated clothes. Rinse skin with plenty of water or shower.
In case of eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowed
Rinse mouth. Do NOT induce vomiting. Rest. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
VAPOR: Irritating to eyes, nose, and throat. LIQUID: Irritating to skin and eyes. (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Ethylene glycol, glycols, and related compounds/
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Specific hazards arising from the chemical
FLAMMABLE. Flashback along vapor trail may occur. Vapor may explode if ignited in an enclosed area. (USCG, 1999)
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.
6.3 Methods and materials for containment and cleaning up
Use personal protective eqipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignitino. Beware of vapors accumulating to form explosive concentrations.
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Fireproof. Cool. Keep in the dark.Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Air sensitive. Forms explosive peroxides on prolonged storage. may form peroxided on contact with air.
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
Recommended Exposure Limit: 10 Hour Time-Weighted Average: 100 ppm (360 mg/cu m).
Recommended Exposure Limit: 15 Minute Short-Term Exposure Limit: 150 ppm (540 mg/cu m).
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
| Physical state | colourless liquid |
|---|---|
| Colour | Colorless liquid |
| Odour | Weak pleasant odor |
| Melting point/ freezing point | 230°C(lit.) |
| Boiling point or initial boiling point and boiling range | 120°C |
| Flammability | Class IC Flammable Liquid: Fl.P. at or above 22.78°C and below 37.78°C.Flammable. |
| Lower and upper explosion limit / flammability limit | Lower and upper flammability limits (% vol/vol) at 150°C in air are 1.48 and 13.74, respectively. |
| Flash point | 32°C(lit.) |
| Auto-ignition temperature | 270°C at 1013 hPa |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | 1.81 mPa-s at 20°C |
| Solubility | In water:soluble |
| Partition coefficient n-octanol/water (log value) | log Kow = -0.49 (est) |
| Vapour pressure | 10.9 mm Hg ( 25 °C) |
| Density and/or relative density | 0.924 |
| Relative vapour density | 3.12 (vs air) |
| Particle characteristics | no data available |
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
Volatile liquid.
10.3 Possibility of hazardous reactions
Moderate, when exposed to heat or flame1-METHOXY-2-PROPANOL is a methoxy alcohol derivative. The ether being relatively unreactive. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Strong oxidizing agents.
10.6 Hazardous decomposition products
Special hazards arising from the substance or mixture: carbon oxides.
11.Toxicological information
Acute toxicity
- Oral: LD50 Rabbit oral 5300 mg/kg /commercial grade/
- Inhalation: LC50 Guinea pig inhalation 15,000 ppm/10 hr
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
A4: Not classifiable as a human carcinogen.
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
- Toxicity to fish: LC50; Species: Pimephales promelas (Fathead minnow); Concentration: >20.8 g/L for 96 hr /Conditions of bioassay not specified in source examined
- Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna /(Water flea)/; Conditions: static; Concentration: 23.3 g/L for 48 hr
- Toxicity to algae: EC50; Species: Selenastrum capricornutum (Algae); Concentration: >1,000 mg/L for 7 days; Effect: growth inhibition /Conditions of bioassay not specified in source examined
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: 1-Methoxy-2-hydroxypropane, present at 100 mg/L, reached 90% of its theoretical BOD in four weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). The aerobic biodegradation of 1-methoxy-2-hydroxypropane was studied in two sandy loam soils; half-lives ranged from <1 day at 0.2 ppm to <7 days at 100 ppm(2). 1-Methoxy-2-propanol was reported to have a half-life of 17.0 days in an OECD 301B Guideline test(3). In a biodegradation test using an APHA method with 1-methoxy-2-propanol, 58% of the theoretical BOD was reached after 20 days(3).
12.3 Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for 1-methoxy-2-hydroxypropane(SRC), using an estimated log Kow of -0.49(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of 1-methoxy-2-hydroxypropane can be estimated to be 1(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1-methoxy-2-hydroxypropane is expected to have very high mobility in soil.
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information
14.1 UN Number
| ADR/RID: UN3092 | IMDG: UN3092 | IATA: UN3092 |
14.2 UN Proper Shipping Name
| ADR/RID: 1-METHOXY-2-PROPANOL |
| IMDG: 1-METHOXY-2-PROPANOL |
| IATA: 1-METHOXY-2-PROPANOL |
14.3 Transport hazard class(es)
| ADR/RID: 3 | IMDG: 3 | IATA: 3 |
14.4 Packing group, if applicable
| ADR/RID: III | IMDG: III | IATA: III |
14.5 Environmental hazards
| ADR/RID: no | IMDG: no | IATA: no |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 1-Methoxy-2-propanol | 1-Methoxy-2-propanol | 107-98-2 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
16.Other information
Information on revision
| Creation Date | Aug 10, 2017 |
|---|---|
| Revision Date | Aug 10, 2017 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
