1.Identification
1.1 GHS Product identifier
| Product name | Chlorendic anhydride |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | Chlorendic anhydride |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | For industry use only. Flame retardants |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
1.5 Emergency phone number
| Emergency phone number | - |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
2.Hazard identification
2.1 Classification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity – single exposure, Category 3
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |  |
|---|---|
| Signal word | Warning |
| Hazard statement(s) | H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. |
| Response | P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor/…if you feel unwell. |
| Storage | P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to ... |
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| Chlorendic anhydride | Chlorendic anhydride | 115-27-5 | none | 100% |
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
Fresh air, rest. Half-upright position. Refer for medical attention.
In case of skin contact
Remove contaminated clothes. Rinse skin with plenty of water or shower.
In case of eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowed
Rinse mouth. Do NOT induce vomiting.
4.2 Most important symptoms/effects, acute and delayed
no data available
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Absorption, Distribution and Excretion
The pharmacokinetics of chlorendic anhydride was evaluated in 4 male and 8 female Holzman's albino rats that ingested 14C-chlorendic anhydride via gavage in a single dose of 3.65 (Group 1: 2 females), 4.00 (Group 2: 4 females), 5.55 (Group 3: 2 females) or 3.62 mg/kg (Group 4: 4 males). Blood was drawn from females treated with 4 mg/kg at 1, 4, 8, 17, 24, 48, 72 and 96 hr after dosing. Urine and feces were collected daily in the Group 1, 3 and 4 rats. Animals were sacrificed 17, 96, 192 and 192 hr, respectively, after treatment, and selected tissues were excised. Regardless of sex, the primary route of excretion was the feces, 70% of the administered dose being eliminated within the first 72 hr. Only 10% of the administered dose was eliminated in the urine. After 192 hr, the maximum residues present in any tissue were <0.1 mg/kg, with the exception of the fat (0.121 mg/kg) and liver (0.296 mg/kg). The blood concentration of chlorendic anhydride peaked 1 hr after dosing and was significantly decreased by 96 hr. The absorption of chlorendic anhydride followed the two-compartment open model. The first compartment was suggested to consist of the blood and selected tissues which equilibrated rapidly, while the second compartment consisted of the fat which was slow in equilibrating and considered a deep reservoir.
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
In case of fire in the surroundings, use appropriate extinguishing media.
5.2 Specific hazards arising from the chemical
no data available
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.
6.3 Methods and materials for containment and cleaning up
Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. (Extra personal protection: P2 filter respirator for harmful particles.)
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Dry. Well closed.Dry. Well closed.
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
no data available
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
| Physical state | white crystalline powder or chunks |
|---|---|
| Colour | Fine white crystals |
| Odour | no data available |
| Melting point/ freezing point | 187°C(lit.) |
| Boiling point or initial boiling point and boiling range | 99°C/14mmHg(lit.) |
| Flammability | Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| Lower and upper explosion limit / flammability limit | no data available |
| Flash point | 81°C(lit.) |
| Auto-ignition temperature | no data available |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | In water:insoluble |
| Partition coefficient n-octanol/water (log value) | log Kow = 4.4 /Estimated/ |
| Vapour pressure | 5.5X10-7 mm Hg @ 25°C /Estimated/ |
| Density and/or relative density | 1.99 g/cm3 |
| Relative vapour density | 13 (vs air) |
| Particle characteristics | no data available |
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
In aqueous solution, chlorendic anhydride is rapidly hydrolysed to chlorendic acid, with a half-life of approximately one hour.
10.3 Possibility of hazardous reactions
Nonflammable
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Chlorendic anhydride will react almost quantitatively with excess methanol to form monomethyl chlorendate
10.6 Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /hydrogen chloride/.
11.Toxicological information
Acute toxicity
- Oral: LD50 Mouse oral 2400 mg/kg
- Inhalation: LC50 Rat (albino) inhalation >5.27 mg/L/4 hr
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
- Toxicity to fish: LC50 Salmo gairdneri (Rainbow trout, mean length 44mm, mean weight 0.61 g, age 3 months) >1000 mg/L/24 hr; 947.6 mg/L/48 hr (95% confidence interval: 785-1144 mg/L); 422.7 mg/L/96 hr; static, pH 7.54, 10°C +/- 1°C, total alkalinity 28 mg/L and CaCO3, total hardness 42 mg/L as CaCO3, specific conductivity 145 umhos/cm /93.81% pure chlorendic anhydride
- Toxicity to daphnia and other aquatic invertebrates: LC50 Daphnia magna (age <20 hr) 127.9 mg/L/24 hr (95% confidence interval: 118.1-138.4 mg/L); 110.7 mg/L/48 hr (95% confidence interval: 97.6-125.6 mg/L); static- nonrenewal, 17 +/- 2°C, pH 4.50-7.43, hardness 52 mg/L as CaCO3, alkalinity 29 mg/L CaCO3, specific conductivity 130 umhos/cm /93.81% pure chlorendic anhydride
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
no data available
12.3 Bioaccumulative potential
no data available
12.4 Mobility in soil
no data available
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information
14.1 UN Number
| ADR/RID: Not dangerous goods. | IMDG: Not dangerous goods. | IATA: Not dangerous goods. |
14.2 UN Proper Shipping Name
| ADR/RID: unknown |
| IMDG: unknown |
| IATA: unknown |
14.3 Transport hazard class(es)
| ADR/RID: Not dangerous goods. | IMDG: Not dangerous goods. | IATA: Not dangerous goods. |
14.4 Packing group, if applicable
| ADR/RID: Not dangerous goods. | IMDG: Not dangerous goods. | IATA: Not dangerous goods. |
14.5 Environmental hazards
| ADR/RID: no | IMDG: no | IATA: no |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| Chlorendic anhydride | Chlorendic anhydride | 115-27-5 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Not Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
16.Other information
Information on revision
| Creation Date | Aug 10, 2017 |
|---|---|
| Revision Date | Aug 10, 2017 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
