1.Identification
1.1 GHS Product identifier
Product name | methyl 2-cyanoprop-2-enoate |
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1.2 Other means of identification
Product number | - |
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Other names | 2-cyano-acrylic acid methyl ester |
1.3 Recommended use of the chemical and restrictions on use
Identified uses | For industry use only. |
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Uses advised against | no data available |
1.4 Supplier's details
1.5 Emergency phone number
Emergency phone number | - |
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Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
2.Hazard identification
2.1 Classification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity – single exposure, Category 3
2.2 GHS label elements, including precautionary statements
Pictogram(s) | |
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Signal word | Warning |
Hazard statement(s) | H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation |
Precautionary statement(s) | |
Prevention | P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. |
Response | P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor/…if you feel unwell. |
Storage | P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. |
Disposal | P501 Dispose of contents/container to ... |
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
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methyl 2-cyanoprop-2-enoate | methyl 2-cyanoprop-2-enoate | 137-05-3 | none | 100% |
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
Fresh air, rest. Refer for medical attention.
In case of skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
In case of eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms/effects, acute and delayed
Exposure Routes: inhalation, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin, nose; blurred vision, lacrimation (discharge of tears); rhinitis Target Organs: Eyes, skin, respiratory system (NIOSH, 2016)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Fires involving this compound should be controlled using a dry chemical, carbon dioxide, foam or Halon extinguisher.
5.2 Specific hazards arising from the chemical
Flash point data for this compound are not available but it is probably non-flammable.
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Personal protection: face shield and filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Do NOT wash away into sewer. Absorb liquid in sand or inert absorbent. Let solidify.
6.3 Methods and materials for containment and cleaning up
Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Separated from incompatible materials. See Chemical Dangers. Well closed. Store only if stabilized.The effectiveness of phenolic inhibitors is dependent on the presence of oxygen and the monomers must be stored under air rather than an inert atmosphere. Temp must be kept low to minimize formation of peroxides and other products. ... The acrylic esters may be stored in mild or stainless steel, or aluminum. /Acrylic acid & derivatives/
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
Recommended Exposure Limit: 10 hr Time-Weighted avg: 2 ppm (8 mg/cu m).
Recommended Exposure Limit: 15 min Short-Term Exposure Limit: 4 ppm (16 mg/cu m).
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
Physical state | PHYSICAL DESCRIPTION: Clear slightly yellow liquid. |
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Colour | Clear, colorless liquid |
Odour | Strong, acrid odor |
Melting point/ freezing point | -40°C |
Boiling point or initial boiling point and boiling range | 174.5oC at 760mmHg |
Flammability | Class IIIA Combustible Liquid: Fl.P. at or above 60°C and below 93.33°C.Combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
Lower and upper explosion limit / flammability limit | no data available |
Flash point | 67.6oC |
Auto-ignition temperature | no data available |
Decomposition temperature | no data available |
pH | no data available |
Kinematic viscosity | 2.2 cP at 25°C |
Solubility | less than 1 mg/mL at 22.22°C |
Partition coefficient n-octanol/water (log value) | 0.03 (estimated) |
Vapour pressure | 1.2mmHg at 25°C |
Density and/or relative density | 1.08g/cm3 |
Relative vapour density | (air = 1): 3.8 |
Particle characteristics | no data available |
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
Liquid /dries/ within 15-45 seconds without aid of catalysts, heat, or solvent evaporation.
10.3 Possibility of hazardous reactions
METHYL 2-CYANOACRYLATE is an unsaturated aliphatic nitrile and acrylate ester. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Moisture (Note: Contact with moisture causes rapid polymerization).
10.6 Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /nitrogen oxides and CN-/.
11.Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 1.6-3.2 g/kg
- Inhalation: LC50 Rat inhalation 101 ppm/6 hr
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
Methyl 2-cyanoacrylate polymerizes rapidly on contact with moisture(1-3). Therefore, biodegradation is not a relevant environmental fate process for this substance(SRC).
12.3 Bioaccumulative potential
Methyl 2-cyanoacrylate polymerizes rapidly on contact with moisture(1,2,3). Therefore, bioconcentration in aquatic organisms is not a relevant environmental process for this substance(SRC).
12.4 Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of methyl 2-cyanoacrylate can be estimated to be 3.7(SRC). According to a classification scheme(2), this estimated Koc value suggests that methyl 2-cyanoacrylate is expected to have very high mobility in soil. However, movement of methyl 2-cyanoacrylate through soil will be hindered by its rapid polymerization as it comes into contact with moisture or other weakly basic substances(3-5).
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information
14.1 UN Number
ADR/RID: no data available | IMDG: no data available | IATA: no data available |
14.2 UN Proper Shipping Name
ADR/RID: no data available |
IMDG: no data available |
IATA: no data available |
14.3 Transport hazard class(es)
ADR/RID: no data available | IMDG: no data available | IATA: no data available |
14.4 Packing group, if applicable
ADR/RID: no data available | IMDG: no data available | IATA: no data available |
14.5 Environmental hazards
ADR/RID: no | IMDG: no | IATA: no |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
Chemical name | Common names and synonyms | CAS number | EC number |
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methyl 2-cyanoprop-2-enoate | methyl 2-cyanoprop-2-enoate | 137-05-3 | none |
European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
EC Inventory | Listed. | ||
United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
Vietnam National Chemical Inventory | Not Listed. | ||
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. |
16.Other information
Information on revision
Creation Date | Aug 19, 2017 |
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Revision Date | Aug 19, 2017 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/