1.Identification
1.1 GHS Product identifier
Product name | cyanazine |
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1.2 Other means of identification
Product number | - |
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Other names | Cyanazine solution |
1.3 Recommended use of the chemical and restrictions on use
Identified uses | For industry use only. Herbicide |
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Uses advised against | no data available |
1.4 Supplier's details
1.5 Emergency phone number
Emergency phone number | - |
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Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
2.Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Oral, Category 4
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
2.2 GHS label elements, including precautionary statements
Pictogram(s) | |
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Signal word | Warning |
Hazard statement(s) | H302 Harmful if swallowed H410 Very toxic to aquatic life with long lasting effects |
Precautionary statement(s) | |
Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment. |
Response | P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell. P330 Rinse mouth. P391 Collect spillage. |
Storage | none |
Disposal | P501 Dispose of contents/container to ... |
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
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cyanazine | cyanazine | 21725-46-2 | none | 100% |
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
Fresh air, rest. Refer for medical attention.
In case of skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap.
In case of eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowed
Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Skin decontamination: Skin contamination should he treated promptly by washing with soap and water. Contamination of the eyes should be treated immediately by prolonged flushing of the eyes with large amounts of clean water. If dermal or ocular irritation persists, medical attention should be, obtained without delay.
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: SMALL FIRE: Dry chemical, CO2 or water spray. LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016)
5.2 Specific hazards arising from the chemical
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. For electric vehicles or equipment, ERG Guide 147 (lithium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. (ERG, 2016)
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Do NOT wash away into sewer. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Cool. Dry.Keep from domestic animals, particularly cattle.
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
no data available
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
Physical state | WHITE CRYSTALLINE POWDER |
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Colour | White crystals |
Odour | no data available |
Melting point/ freezing point | 167oC |
Boiling point or initial boiling point and boiling range | 442.4oC at 760 mmHg |
Flammability | Not combustible. Liquid formulations containing organic solvents may be flammable. |
Lower and upper explosion limit / flammability limit | no data available |
Flash point | 221.4oC |
Auto-ignition temperature | no data available |
Decomposition temperature | no data available |
pH | no data available |
Kinematic viscosity | no data available |
Solubility | In water:0.0171 g/100 mL |
Partition coefficient n-octanol/water (log value) | log Kow= 2.22 |
Vapour pressure | 5.03E-08mmHg at 25°C |
Density and/or relative density | 1.341 g/cm3 |
Relative vapour density | no data available |
Particle characteristics | no data available |
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
Very stable to heat and UV light. Stable between pH 5 and 9, but hydrolyzed by strong acids and alkalis.
10.3 Possibility of hazardous reactions
A triazine derivative.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
no data available
10.6 Hazardous decomposition products
When heated to decomposition, it emits very toxic fumes of /hydrogen chloride, nitrogen oxides and hydrogen cyanide/.
11.Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 288 mg/kg
- Inhalation: no data available
- Dermal: LD50 Rat percutaneous >1200 mg/kg
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Cancer Classification: Group C Possible Human Carcinogen
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
- Toxicity to fish: LC50 Pimephales promelas (Fathead minnow) 16.3 mg/l/96 hr @ 18°C (95% confidence interval 14.2-18.0 mg/l), wt 0.9 g. Static bioassay without aeration, pH 7.2-7.5, water hardness 40-50 mg/l as calcium carbonate and alkalinity of 30-35 mg/l. /Technical material 100%
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: The half-life of 2.0 ppm of cyanazine in samples of Regina Heavy Clay soil (70% clay, 25% silt and 5% sand) was determined under various laboratory soil moisture and temperature conditions(1). The half-life at 34% soil moisture content varied from 19 to 3 days at temperatures of 5 and 30 degrees C, respectively; at 8% moisture content and 20 degrees C, the half-life was greater than 200 days (1). In field experiments, the half-life of cyanazine, initially applied at approximately 5.5 lbs/acre, was approximately 30 days; after 56 days, less than 10% of the cyanazine remained(1). In the lab and field experiments, the degradation of cyanazine occurred more rapidly than metribuzin and atrazine(1). The degradation of cyanazine was measured under field conditions over a four year period and under different tillage treatments(2). Approximately 8 percent of cyanazine, initially applied at 5.5-8.8 lbs/acre, remained 2 and 4 weeks after application under no-till and conventional tilling conditions, respectively(2). Approximately 19 and 24 percent of cyanazine, initially present at 250 umol/kg, remained after 42 days in a silt loam soil that was amended with ryegrass and cornmeal, respectively; 36 percent of the applied cyanazine remained in unamended soil and soil amended with poultry litter(3). Three metabolites of cyanazine were observed (in decreasing order): hydroxy cyanazine, cyanazine amide and deethyl cyanazine(3). In a cyanazine metabolite study, cyanazine amide and de-isopropylated atrazine were detected as soil degradation products(4); it was proposed that hydrolysis preceded microbial degradation to yield the de-isopropylated atrazine(4). Persistence studies over a 20-week period at varying temperatures (5, 20, 35 and 50°C) found that cyanazine degraded within 10 weeks at 5°C and within 5 weeks at the higher temperatures(5); the initial observed half-lives at the higher temperatures were 1.5-2.0 weeks(5); it has been suggested that degradation of cyanazine at -10°C is not very likely(6). A half-life of 6 days was observed in a cornfield study in Quebec, Canada(7).
12.3 Bioaccumulative potential
Using a system developed by R. Metcalf, (14)C-ring-labeled cyanazine was introduced into an aquatic model ecosystem. After 35 days, analyses of the components were conducted. In addition to unchanged cyanazine, N-deethylcyanazine, cyanazine amide, N-deethylcyanazine amide, and three unknowns were found in the water. Radioactivity did not increase in the food chain of algae to mosquitoes to fish (a decrease from 1.3 to 0.05 ppm was observed), indicating that this compound does not concentrate through the food chain.
12.4 Mobility in soil
An experimentally determined Koc of 200 has been reported (soil type not given)(1). A Koc of 182 was measured in a silty soil(2). Using soil TLC, an intermediate mobility was measured in a silty clay loam (Rf of 0.39) and a high mobility was measured in a sandy loam (Rf of 0.74)(3); the avg Koc for these two soils was reported as 372(4). A Koc of 97 was measured for a silt loam soil from a corn field(5); in field studies using this soil (0.70% organic carbon), a max of 0.04% of surface application was lost through subsurface tile drains(5). In field studies, cyanazine did not leach below a 0.20 m depth in a sandy loam soil(6) or below a 0.30 m depth in a silt loam soil(7). However, cyanazine leached through 0.90 m of a soil composed of 29% clay, 49% silt and 22% sand(8). Cyanazine is reversibly adsorbed to soil particles(9); adsorption increases with increased organic matter content, decreasing soil water and decreasing pH(9). The adsorption of cyanazine by microbial biomass has been observed(10). According to a classification scheme(11), the measured Koc values suggest that cyanazine is expected to have moderate to high mobility in soil(SRC).
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information
14.1 UN Number
ADR/RID: UN2588 | IMDG: UN2588 | IATA: UN2588 |
14.2 UN Proper Shipping Name
ADR/RID: PESTICIDE, SOLID, TOXIC, N.O.S. |
IMDG: PESTICIDE, SOLID, TOXIC, N.O.S. |
IATA: PESTICIDE, SOLID, TOXIC, N.O.S. |
14.3 Transport hazard class(es)
ADR/RID: 6.1(b) | IMDG: 6.1(b) | IATA: 6.1(b) |
14.4 Packing group, if applicable
ADR/RID: III | IMDG: III | IATA: III |
14.5 Environmental hazards
ADR/RID: yes | IMDG: yes | IATA: yes |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
Chemical name | Common names and synonyms | CAS number | EC number |
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cyanazine | cyanazine | 21725-46-2 | none |
European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
EC Inventory | Listed. | ||
United States Toxic Substances Control Act (TSCA) Inventory | Not Listed. | ||
China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Not Listed. | ||
Vietnam National Chemical Inventory | Not Listed. | ||
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. |
16.Other information
Information on revision
Creation Date | Aug 17, 2017 |
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Revision Date | Aug 17, 2017 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/