1.Identification
1.1 GHS Product identifier
| Product name | benzo[a]pyrene |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | benzo(a)pyrene |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | For industry use only. Food Contaminant: CONTAMINANT |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
1.5 Emergency phone number
| Emergency phone number | - |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
2.Hazard identification
2.1 Classification of the substance or mixture
Skin sensitization, Category 1
Germ cell mutagenicity, Category 1B
Carcinogenicity, Category 1B
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
Reproductive toxicity, Category 1B
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |    |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H317 May cause an allergic skin reaction H340 May cause genetic defects H350 May cause cancer H410 Very toxic to aquatic life with long lasting effects H360FD |
| Precautionary statement(s) | |
| Prevention | P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/face protection. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P273 Avoid release to the environment. |
| Response | P302+P352 IF ON SKIN: Wash with plenty of water/... P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P308+P313 IF exposed or concerned: Get medical advice/ attention. P391 Collect spillage. |
| Storage | P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to ... |
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| benzo[a]pyrene | benzo[a]pyrene | 50-32-8 | none | 100% |
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
Fresh air, rest.
In case of skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap.
In case of eye contact
Rinse with plenty of water (remove contact lenses if easily possible).
If swallowed
Rinse mouth.
4.2 Most important symptoms/effects, acute and delayed
SYMPTOMS: Symptoms of exposure to this compound include mucous membrane irritation, dermatitis, bronchitis, cough, dyspnea, conjunctivitis, photosensitization, pulmonary edema, reproductive effects and leukemia. Contact with the skin may result in erythema, pigmentation, desquamation, formation of verrucae and infiltration. It may also cause keratoses which are relatively small, heaped-up, scaling, brown plaques on the skin, some of which may be fissured and may itch. Exposure to this type of compound may cause reddening and squamous eczema of the lid margins with only small erosion of the corneal epithelium and superficial changes in the stroma which disappear a month following exposure. Repeated exposure may cause sunlight to have a more severe effects on a person's skin and also an allergic skin rash. Aplastic anemia may also occur. Chronic exposure to the fumes and dust of this type of compound can cause discoloration of the cornea and epithelioma of the lid margin. ACUTE/CHRONIC HAZARDS: This compound may be harmful by ingestion or inhalation. It may cause irritation. When heated to decomposition it emits acrid smoke and toxic fumes of carbon monoxide and carbon dioxide.
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Aromatic hydrocarbons and related compounds/
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Flammable, but generally found in such low quantities it is not considered a fire hazard ... Poisonous gases are produced in fire including carbon monoxide. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any signs of deforming), withdraw immediately to a secure position.
5.2 Specific hazards arising from the chemical
Literature sources indicate that this chemical is nonflammable.
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Do NOT wash away into sewer. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Provision to contain effluent from fire extinguishing. Separated from strong oxidants. Store in an area without drain or sewer access. Cool. Dry.Store in tightly closed containers in a cool, well-ventilated area away from oxidizing chemicals (such as chlorates, perchlorates, permanganates, and nitrates). A regulated, marked area should be established where this chemical is handled, used, or stored in compliance with OSHA standard 1910.1045.
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 0.1 mg/cu m (cyclohexane-extractable fraction). /Coal tar pitch volatiles/
NIOSH considers coal tar pitch volatiles to be potential occupational carcinogens. /Coal tar pitch volatiles/
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
| Physical state | yellow to brown powder. |
|---|---|
| Colour | PALE YELLOW MONOCLINIC NEEDLES FROM BENZENE & METHANOL |
| Odour | Faint aromatic odor |
| Melting point/ freezing point | 207°C(lit.) |
| Boiling point or initial boiling point and boiling range | 496°C(lit.) |
| Flammability | Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| Lower and upper explosion limit / flammability limit | no data available |
| Flash point | 73°C(lit.) |
| Auto-ignition temperature | no data available |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | less than 1 mg/mL at 17.22°C |
| Partition coefficient n-octanol/water (log value) | log Kow = 6.13 |
| Vapour pressure | 5.49e-09 mm Hg at 25°C |
| Density and/or relative density | 1.286 g/cm3 |
| Relative vapour density | 8.7 (Relative to Air) |
| Particle characteristics | no data available |
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
Undergoes photo-oxidation after irradiation in indoor sunlight or by fluorescent light in organic solvents.
10.3 Possibility of hazardous reactions
Combustible.BENZO[A]PYRENE undergoes photo-oxidation after irradiation in indoor sunlight or by fluorescent light in organic solvents. Incompatible with strong oxidizing agents including various electrophiles, peroxides, nitrogen oxides and sulfur oxides. Oxidized by ozone, chromic acid and chlorinating agents. Readily undergoes nitration and halogenation. Hydrogenation occurs with platinum oxide .
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Incompatibilities: strong oxidizers, nitrogen dioxide, and ozone.
10.6 Hazardous decomposition products
When heated to decomposition it emits acrid smoke and fumes.
11.Toxicological information
Acute toxicity
- Oral: no data available
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
CLASSIFICATION: B2; probable human carcinogen. BASIS FOR CLASSIFICATION: Human data specifically linking benzo(a)pyrene (BAP) to a carcinogenic effect are lacking. There are, however, multiple animal studies in many species demonstrating BAP to be carcinogenic following administration by numerous routes. BAP has produced positive results in numerous genotoxicity assays. NOTE: At the June, 1992 CRAVE Work Group meeting, a revised risk estimate for benzo(a)pyrene was verified. ... The Carcinogenicity Background Document provides details on the rationale and methods used to derive the carcinogenicity values found in IRIS. ... HUMAN CARCINOGENICITY DATA: Inadequate. ANIMAL CARCINOGENICITY DATA: Sufficient. /Based on former classification system/
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
- Toxicity to fish: LT50 (time to 50% mortality); Species: Pimephales promelas (Fathead minnow, larvae 7 days posthatch); Conditions: freshwater, renewal; Concentration: 5.6 ug/L for 40.05 hr
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea, about 4 days old juvenile); Conditions: freshwater, static, 20°C, pH 8.0, alkalinity 250 mg/L CaCO3; Concentration: 40 ug/L for 24 hr (95% confidence interval: 32-49 ug/L); Effect: intoxication, immobilization
- Toxicity to algae: EC50; Species: Pseudokirchneriella subcapitata (Green algae, 500000 cells/mL); Conditions: freshwater, static, 23°C; Concentration: 15 ug/L for 72 hr; Effect: growth, general /97% purity
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: (14)C-benzo(a)pyrene was not significantly mineralized in sludge treated Caledon soil; half-lives ranged from 23 to 266 weeks(1). The persistence of benzo(a)pyrene in soil is expected to vary depending upon the nature of compounds accompanying it and the nature and previous history of the soil(1). After 5 days incubation in activated sludge, <0.1% of the applied (14)C-benzo(a)pyrene concn was degraded to (14)-CO2(2). Incubation of (14)C-benzo(a)pyrene in creosote-pentachlorophenol contaminated soil over 285 days led to a small, <1%, mineralization of benzo(a)pyrene(3). Calculated half-lives for the mineralization of (14)C-benzo(a)pyrene in sediment/water microcosms ranged from >200 weeks in Redfish Bay, TX to >300 weeks in Lake Chicot, AR; no mineralization was detected in microcosms containing sediment and water from DeGray Reservoir, AR(4). The extent of mineralization of (14)C-benzo(a)pyrene, at a concentration of 105 ng/g, in soils collected from an abandoned coal tar refinery was very low, <8%, after 160 days(5). The level of indigenous mineralization of (14)C-benzo(a)pyrene in soils obtained from three abandoned coal gasification plants as measured by serum bottle respirometry ranged from not detectable to 25% following incubations >180 days; (14)C-benzo(a)pyrene mineralization occurred after a 28-day lag period(6). In soils from Alert (contaminated with Arctic diesel fuel), Saglek (from a radar installation), Varta (from a former gasworks site), and Westbrook (not known to be polluted), the percent removal of benzo(a)pyrene (10 ug/mL concn) from enrichment cultures after 90 days incubation under aerobic conditions were, respectively: at 20°C, 68, 76, 60, and 27; at 7°C, 33, 31, 34 and 37(7).
12.3 Bioaccumulative potential
Gillichthys mirabilis (mudsucker) exposed to benzo(a)pyrene /concn not specified/ for 96 hr exhibited a bioconcentration factor of 0.048; Oligocottus maculosus (tidepool sculpin) exposed to benzo(a)pyrene /concn not specified/ for 1 hr exhibited a bioconcentration factor of 0.13; Citharichthys stigmacus (sand dab) exposed to benzo(a)pyrene /concn not specified/ for 1 hr exhibited a bioconcentration factor of 0.02. /Edible tissue/
12.4 Mobility in soil
Sorption coefficients for benzo(a)pyrene obtained during 48 hour batch experiments using two lake sediments with organic carbon content of 1.87 and 2.07%, and a high chemical concentration were 7,000 and 22,000, respectively(1). Sorption coefficients obtained from 48 hour batch experiments using a low benzo(a)pyrene concentration were 8,700 and 35,000 using lake sediments with 1.87% and 2.07% organic carbon, respectively(1). These values correspond to estimated Koc values of 2.7X10+5, 1.1X10+6, 4.7X10+5, and 1.7X10+6(SRC) using a regression-derived equation(2).. Sorption removal accounted for >3.0% and >3.2% of the benzo(a)pyrene present in the influent of a high-loaded laboratory scale activated sludge reactor and a biological aerated filter reactor, respectively; the calculated adsorption removal may be conservatively low because the sludge samples were dried before analysis(3). Kd, soil/water partition coefficients, of 18.2 and 69.0 were determined in Kidman sandy loam, 0.51% organic carbon, and Nunn clay loam, 1.1% organic carbon(4). These values correspond to Koc values of 930 and 6300, respectively(SRC), using a regression-derived equation(2).. Measured log Koc values ranged from 6.00 to 6.28 in sediments and porewater isolated from three cores from Boston Harbor, MA(5). Sorption partition coefficients for benzo(a)pyrene with natural dissolved organic carbon from Lake Ketelmeer ranged from 2.8X10+6 at 45°C to 1.6X10+7 at 16°C(6). A sorption partition coefficient of 2.5X10+6 was observed for benzo(a)pyrene with particulate organic matter from Lake Ketelmeer at 20°C(6). Average partition coefficients for benzo(a)pyrene in natural interstitial waters ranged from 2.2X10+3 and 9.0X10+6 for Government Pond, Grand Haven, MI and Lake Michigan, respectively(7). Sorption of (14)C-benzo(a)pyrene on sediment collected in the harbor of Rotterdam was measured using batch experiments; cosolvent partition coefficients(log) ranged from 5.2 to 6.3(8). Partition coefficients (log) for (14)C-benzo(a)pyrene using fulvic and humic acids derived from salt-marsh estuaries ranged from 3.48 to 3.86 and 4.12 to 4.29, respectively(9). Benzo(a)pyrene log Kp values ranged from 5.18 to 5.79 in porewater and 4.90 to 5.36 in elutriates(10). 22% benzo(a)pyrene removal over 36 days in an activated sludge pilot reactor was attributed to adsorption to sludge(11). According to a recommended classification scheme(12), these Koc values suggest that benzo(a)pyrene is expected to have low to no mobility in soil(SRC).
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information
14.1 UN Number
| ADR/RID: UN3077 | IMDG: UN3077 | IATA: UN3077 |
14.2 UN Proper Shipping Name
| ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. |
| IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. |
| IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. |
14.3 Transport hazard class(es)
| ADR/RID: 9 | IMDG: 9 | IATA: 9 |
14.4 Packing group, if applicable
| ADR/RID: III | IMDG: III | IATA: III |
14.5 Environmental hazards
| ADR/RID: yes | IMDG: yes | IATA: yes |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| benzo[a]pyrene | benzo[a]pyrene | 50-32-8 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
16.Other information
Information on revision
| Creation Date | Aug 11, 2017 |
|---|---|
| Revision Date | Aug 11, 2017 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
