1.Identification

1.1 GHS Product identifier

1.2 Other means of identification

1.3 Recommended use of the chemical and restrictions on use

1.4 Supplier's details

1.5 Emergency phone number

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Serious eye damage, Category 1

Skin sensitization, Category 1

Specific target organ toxicity – single exposure, Category 3

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H302 Harmful if swallowed H318 Causes serious eye damage H317 May cause an allergic skin reaction H335 May cause respiratory irritation H412 Harmful to aquatic life with long lasting effects
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment.
Response	P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell. P330 Rinse mouth. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a POISON CENTER/doctor/… P302+P352 IF ON SKIN: Wash with plenty of water/... P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor/…if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap.

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

SYMPTOMS: Symptoms of exposure to this material include weakness, muscle twitching, stupor, vomiting, abdominal cramps, diarrhea and anorexia. Central nervous system effects and myotonia can also occur. It is irritating to skin, eyes, mucous membranes and the upper respiratory tract. ACUTE/CHRONIC HAZARDS: This compound is irritating to skin, eyes, mucous membranes and upper respiratory tract. It emits toxic fumes when heated to decomposition.

Dust may irritate eyes. Ingestion causes gastroentric distress, diarrhea, mild central nervous system depression, dysphagia, and possible transient liver and kidney injury. (USCG, 1999)

INHALATION: Inflamed mucous membranes. EYES: Contact may cause irritation and swelling. SKIN: Irritation, rashes and swelling. INGESTION: Weakness and lethargy, anorexia, diarrhea, spasticity and possible death from ventricular fibrillation and subsequent cardiac arrest. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Chlorophenoxy herbicides and related compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Extinguishant: Carbon dioxide, dry chemical, foam, and water.

5.2 Specific hazards arising from the chemical

Flash point data for this compound are not available. It is probably combustible.

Special Hazards of Combustion Products: Toxic and irritating hydrogen chloride or phosgene gases may form. (USCG, 1999)

Special Hazards of Combustion Products: Emits noxious fumes. Behavior in Fire: Emits noxious fumes, including chlorides. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered plastic containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Accidental Release Measures. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Store in an area without drain or sewer access. Separated from strong oxidants and food and feedstuffs.Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Light sensitive. Moisture sensitive.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hour Time-Weighted Average: 10 mg/cu m.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

Not combustibleThis material is incompatible with strong oxidizers.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Contact with strong oxidizers may cause fires or explosions.

10.6 Hazardous decomposition products

When heated to decomposition it emits toxic fumes of /chlorides/.

11.Toxicological information

Acute toxicity

• Oral: LD50 Rat Fischer-344 male oral 443 mg/kg (95% confidence limits 270-1103 mg/kg) (2,4-D acid in corn oil).
• Inhalation: no data available
• Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

EPA: Not classifiable as to human carcinogenicity. IARC: Possibly carcinogenic to humans. NTP: Not evaluated

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

• Toxicity to fish: LC50; Species: Salvelinus namaycush (lake trout) weight 0.3 g; Conditions: static bioassay at 10°C, without aeration, pH 7.2-7.5, water hardness 40-50 mg/L as calcium carbonate and alkalinity of 30-35 mg/L; Concentration: 45 mg/L for 96 hr (95% confidence limit 35-56 mg/L) /2,4-D acid, granular 100%
• Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (water flea); Concentration: 363-389 mg/L for 48 hr /Conditions of bioassay not specified, SRP: Unspecified salt or ester of 2,4-D
• Toxicity to algae: LC50; Species: Pseudokirchneriella subcapitata (Green Algae); Conditions: freshwater, static; Concentration: 20700 ug/L for 5 days /96.1% purity
• Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: 2,4-D is readily and rapidly degraded in soil(1). The kinetics of 2,4-D disappearance suggest that microorganisms are responsible(1). The rate will depend on a number of factors including presence of acclimated organisms, nutrient levels, moisture level, temperature, and concentration of 2,4-D(1-3). Typical half-lives range from less than 1 day to more than several weeks under the conditions used(4-8). Degradation with a mixture of microorganisms from activated sludge, soil and sediments lead to half-lives of 1.8-3.1 days under aerobic conditions(4,9). Particular species of microorganisms, of various types, have been isolated and shown to degrade phenoxyacetic acid herbicides in pure culture(1). Degradation of the phenoxyacetic acids proceeds by two main pathways(1). These are via a hydroxyphenoxy acetic acid intermediate or via the corresponding phenol(1). Warm, moist conditions and addition of organic matter stimulate degradation of 2,4-D(7). The breakdown of 2,4-D in two types of soil was investigated under dry and moist conditions and at two different temperatures(7). Generally, 2,4-D disappeared more rapidly from moist soil; after 14 days of a slow rate of disappearance, however, the removal rate from dry, sandy soil increased(7). Numbers of organisms degrading 2,4-D were initially much lower in sandy than in clay loams(7). However, numbers increased rapidly in sandy soils after the addition of the herbicide and, as a result, 2,4-D was eventually degraded more rapidly in sandy than in clay loams(7). In moist conditions, at 25°C, the half-life of 2,4-D was 7 days or less, whereas in dry conditions, at 35°C, it could be as long as 250 days(7). These latter conditions are unlikely to apply in most natural conditions where 2,4-D is likely to be used(7). First-order kinetics were observed for the degradation of 2,4-D in sandy loam and muck soils from Malaysia(10). Short half-lives were observed for 2,4-D in aerobic (3.4 days) muck soils(10).

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated in fish for 2,4-D(SRC), using a log Kow of 2.81(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). The Japanese Chemicals Evaluation and Research Institute has classified 2,4-D as not highly bioaccumulative(4). A depuration half-life of 1.32 days was measured channel catfish (Ictalurus punctatus) exposed to 0.01 ppm 2,4-D over a period of 4 days(5). Rapid depuration was observed for rainbow trout (Salmo gairdneri), channel catfish (Ictalurus punctatus) and bluegill sunfish (Lepomis macrochirus) following 8-hr exposure to 0.3 or 1.0 mg/L C14-labeled 2,4-D butoxyethanol ester(6). Uptake by three seaweeds (Ulva sp, Enteromorpha sp, Rhodymenia sp) at pH 7.8 ranged from 0.01-0.03% of 2,4-D added using 25 ppb C14 ring-labeled 2,4-D(7). Bioaccumulation factors of <10 and 6 were reported for golfen orfe (Leuciscus idus mealnotus) and algae (Chlorella fusca), respectively(8).

12.4 Mobility in soil

Reported experimental 2,4-D (free acid) Koc values are 19.6 (average of 9 soils)(1) to 109.1 (average of 3 soils and range of 72.2-135.7)(2), and 20 to 79(3). According to a classification scheme(4), these Koc values suggest that 2,4-D is expected to have high to very high mobility in soil(SRC). The pKa of 2,4-D is 2.73(5). Anionic 2,4-D adsorption is affected by soil mineralogy (in particular iron and aluminum oxide content), exchangeable aluminum content, and soil phosphate content(6). Adsorption appears to increase with increasing organic content and decreasing pH of soil(7). Average mobility for 14 soils was 0.72 (Rf units), ranging from 0.41 for silty loam to 1.0 for sandy loam(7). In general little runoff occurs with 2,4-D or its amine salts and runoff behavior is the inverse of adsorption behavior(8). Thus, 2,4-D can be desorbed from mineral soils, but not from those containing much organic matter(8). Percolating water appears to be the principal means of movement and diffusion is important only for transport over very small distance(8). Geometric mean concentrations of leached 2,4-D ranged from 0.55-0.87 ug/L at a depth of 0.2 m following applications (rate 0.1-3.3 kg/ha-yr) of the herbicide and irrigation of home garden lawns(9). Upward movement of 2,4-D occurs when the soil surface dries or if rapid evaporation occurs(9). Thus, 2,4-D can be concentrated at the soil surface, where it can be photolyzed, transported by wind either on dust or in vapor form, or leached downwards again(9).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

14.2 UN Proper Shipping Name

14.3 Transport hazard class(es)

14.4 Packing group, if applicable

14.5 Environmental hazards

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

16.Other information

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.