1000994-24-0Relevant articles and documents
Preparation method of 5-(tert-butyloxycarbonyl)-2-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-C]pyridine-7-carboxylic acid
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, (2019/12/25)
The invention relates to a preparation method of 5-(tert-butyloxycarbonyl)-2-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-C]pyridine-7-carboxylic acid, and mainly solves the technical problem that a method suitable for industrial synthesis does not exist at present. The method comprises four steps: firstly, carrying out a reaction of a compound 1 and N,N-dimethylformamide dimethylacetal to obtain a compound 2; then, carrying out a reaction of the compound 2 and hydrazine hydrate in ethanol to obtain a compound 3; carrying out a reaction of the compound 3 with methyl iodide in an ethyl acetate solvent and with cesium carbonate as an alkali, to generate a compound 4; and finally, hydrolyzing the compound 4 with sodium hydroxide in water and ethanol to obtain a target compound 5. The obtained compound is a useful intermediate or product for synthesizing many medicines.
NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION
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Page/Page column 101; 102, (2008/06/13)
The embodiments provide compounds of the general Formula (I), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments provide compounds of the general Formula (II), as well as compositions, including