The research focuses on the efficient green synthesis of Schiff bases and azetidinones derivatised with 1,2,4-triazoles. The study employs Mg(ClO4)2 as a catalyst for the synthesis of Schiff bases from 1-amino-2-aryl-3-oxo-1,2,4-triazoles with various aldehydes under solvent-free conditions. The resulting Schiff bases are then reacted with chloroacetyl chloride to yield azetidinones, also in solvent-free conditions, with excellent yields. The synthesized compounds were analyzed for their potential as drugs by evaluating properties such as penetration into biological membranes (clogP), drug-likeliness, and drug scores. Additionally, the compounds were screened for antitubercular and antimicrobial activities. The analyses included techniques such as IR spectroscopy, 1H NMR spectroscopy, mass spectrometry, and elemental analysis, as well as thin layer chromatography (TLC) to check the purity of the compounds. The pharmacological evaluation was carried out at a separate facility, and the OSIRIS property explorer was used for computational drug analysis.
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