1037367-40-0Relevant articles and documents
Bicyclic Pyrrolidines for Medicinal Chemistry via [3 + 2]-Cycloaddition
Chalyk, Bohdan A.,Hryshchuk, Oleksandr V.,Isakov, Andrii O.,Kovalenko, Dmytro V.,Melnychuk, Pavlo V.,Mykhailiuk, Pavel K.,Mykhalchuk, Vladimir L.,Pavlenko, Sergiy O.,Reznik, Vitalii A.,Rusanov, Eduard B.,Savchuk, Taras,Savych, Vladimir I.,Siry, Sergiy A.,Timoshenko, Vadim M.,Yarmolchuk, Vladimir S.
, p. 13289 - 13309 (2021/09/13)
A general approach to bicyclic fused pyrrolidines via [3 + 2]-cycloaddition between nonstabilized azomethyne ylide and endocyclic electron-deficient alkenes was elaborated. Push-pull alkenes and CF3-alkenes did not react with the azomethyne ylide under the previously reported conditions, and we developed a superior protocol (LiF, 140 °C, no solvent). Among obtained products were medchem-relevant bicyclic sulfones, monofluoro-, difluoro-, and trifluoromethyl-substituted pyrrolidines. This approach not only allowed preparation of novel molecules but also significantly simplified synthesis of the existing ones (e.g., sofinicline).
ANTIBACTERIAL COMPOUNDS
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Page/Page column 35; 36, (2012/04/18)
The present invention provides a compound of the following formula and salts thereof: Also provided is the use of these compounds as antibacterials, compositions comprising them and processes for their manufacture.
FUSED SUBSTITUTED AMINOPYRROLIDINE DERIVATIVE
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Page/Page column 237-239, (2008/12/07)
A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacteria
ANTIBACTERIAL AGENTS
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Page/Page column 36, (2010/10/19)
Naphthalene, quinoline, quinoxaline and naphthyridine derivatives useful in the treatment bacterial infections in mammals, particularly humans, are disclosed herein.
