1060814-36-9 Usage
Uses
Used in Organic Synthesis:
5-tert-butyl 2-ethyl 6,7-dihydrofuro[3,2-c]pyridine-2,5(4H)-dicarboxylate is used as a key intermediate in organic synthesis for the creation of various complex organic molecules. Its unique structure allows for versatile chemical reactions, facilitating the synthesis of a broad range of compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-tert-butyl 2-ethyl 6,7-dihydrofuro[3,2-c]pyridine-2,5(4H)-dicarboxylate is utilized as a building block for the development of new drugs. Its distinctive molecular framework provides a foundation for the design of innovative therapeutic agents with potential applications in treating various diseases.
Used in Medicinal Chemistry:
5-tert-butyl 2-ethyl 6,7-dihydrofuro[3,2-c]pyridine-2,5(4H)-dicarboxylate is employed as a structural component in medicinal chemistry to explore its potential as a lead compound for drug discovery. Its unique features may contribute to the development of novel pharmaceuticals with improved efficacy and selectivity.
Used in Chemical Research:
5-tert-butyl 2-ethyl 6,7-dihydrofuro[3,2-c]pyridine-2,5(4H)-dicarboxylate is also used in academic and industrial chemical research to study its reactivity, stability, and potential applications in various chemical processes. Understanding its properties can lead to the discovery of new synthetic routes and applications in the chemical sciences.
Overall, 5-tert-butyl 2-ethyl 6,7-dihydrofuro[3,2-c]pyridine-2,5(4H)-dicarboxylate is a versatile chemical entity with broad applications across different fields, particularly in the development of new pharmaceuticals and organic synthesis methodologies.
Check Digit Verification of cas no
The CAS Registry Mumber 1060814-36-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,6,0,8,1 and 4 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1060814-36:
(9*1)+(8*0)+(7*6)+(6*0)+(5*8)+(4*1)+(3*4)+(2*3)+(1*6)=119
119 % 10 = 9
So 1060814-36-9 is a valid CAS Registry Number.
1060814-36-9Relevant articles and documents
Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation
Shao, Jingwei,Zhu, Kongkai,Du, Daohai,Zhang, Yuanyuan,Tao, Hongrui,Chen, Zhifeng,Jiang, Hualiang,Chen, Kaixian,Luo, Cheng,Duan, Wenhu
, p. 317 - 333 (2019)
Protein arginine methyltransferases 5 (PRMT5) represents an attractive drug target in epigenetic field for the treatment of leukemia and lymphoma. Here, a series of N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)amide derivatives targeting PRMT5 were designed with structure-based approach and synthesized. Among them, compound 46 showed potent and selective PRMT5 inhibition activity with an IC50 of 8.5 nM, which was approximately equivalent with the phase I clinical trial PRMT5 inhibitor GSK-3326595 (IC50 = 5.5 nM). Compound 46 also displayed pronounced anti-proliferative activity in MV4-11 cells (GI50 = 18 nM) and antitumor activity in MV4-11 mouse xenografts model. This molecule can serve as an excellent tool compound for probing the biological function of PRMT5.
HISTONE DEACETYLASE INHIBITORS
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Page/Page column 39, (2012/09/21)
Provided herein are isoform selective histone deacetylase inhibitors of the formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, metabolites, prodrugs, solvates, pharmaceutically acceptable salts and compositions thereof. These compounds are isoform selective inhibitors of HDACs and are useful as a therapeutic or ameliorating agent for diseases that are involved in cellular growth such as cancer, malignant tumors, autoimmune diseases, skin diseases, fungal infections, protozoal infections, HIV, inflammation and CNS disorders.
