1107658-78-5Relevant articles and documents
INHIBITORS OF CBL-B AND METHODS OF USE THEREOF
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Paragraph 1879; 2324, (2019/08/12)
Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo.
HETEROCYCLIC COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
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Page/Page column 148, (2017/08/01)
The present application is concerned with heterocyclic compounds that inhibit the activity of Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancers and other diseases.
PYRAZOL DERIVATIVES
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Page/Page column 17, (2009/02/11)
The invention is concerned with novel pyrazol derivatives of formula (I), wherein R1, R2, R3, R4, X and Y are as defined herein, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor and/or CCR-5 receptor and can be used as medicaments.