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5-Bromo-3-fluoro-1H-indazole, a heterocyclic aromatic compound with the molecular formula C7H4BrFN2, features a five-membered ring structure adorned with a bromine atom at the 5-position and a fluorine atom at the 3-position. This unique chemical entity is recognized for its potential applications in the synthesis of bioactive molecules and pharmaceuticals, as well as its studied properties in anti-inflammatory and anti-cancer research.

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  • 1211537-09-5 Structure
  • Basic information

    1. Product Name: 5-broMo-3-fluoro-1H-indazole
    2. Synonyms: 5-broMo-3-fluoro-1H-indazole;5-Bromo-3-fluoroindazole
    3. CAS NO:1211537-09-5
    4. Molecular Formula: C7H4BrFN2
    5. Molecular Weight: 215.0224632
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1211537-09-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 337.2±22.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.861±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. PKA: 10.84±0.40(Predicted)
    10. CAS DataBase Reference: 5-broMo-3-fluoro-1H-indazole(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5-broMo-3-fluoro-1H-indazole(1211537-09-5)
    12. EPA Substance Registry System: 5-broMo-3-fluoro-1H-indazole(1211537-09-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1211537-09-5(Hazardous Substances Data)

1211537-09-5 Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-3-fluoro-1H-indazole is utilized as a key intermediate in the synthesis of various bioactive molecules and pharmaceutical drugs. Its unique structure and functional groups make it a valuable component in the development of new therapeutic agents.
Used in Medicinal Chemistry Research:
5-broMo-3-fluoro-1H-indazole serves as a promising candidate in medicinal chemistry for its potential anti-inflammatory and anti-cancer properties. Its ability to modulate biological pathways and target specific cellular processes positions it as a candidate for further research and development in the treatment of various diseases.
Used in Agricultural Applications:
5-Bromo-3-fluoro-1H-indazole also finds use as a building block in the development of new chemical entities for agricultural purposes. Its potential to influence plant growth, disease resistance, or pest control makes it a valuable asset in the creation of innovative agrochemicals.
Used in Chemical Synthesis:
As a versatile chemical compound, 5-Bromo-3-fluoro-1H-indazole is employed in the synthesis of a range of organic and inorganic compounds, expanding its utility beyond the realms of medicine and agriculture into broader chemical research and development.

Check Digit Verification of cas no

The CAS Registry Mumber 1211537-09-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,1,5,3 and 7 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1211537-09:
(9*1)+(8*2)+(7*1)+(6*1)+(5*5)+(4*3)+(3*7)+(2*0)+(1*9)=105
105 % 10 = 5
So 1211537-09-5 is a valid CAS Registry Number.

1211537-09-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-bromo-3-fluoro-1H-indazole

1.2 Other means of identification

Product number -
Other names 5-bromo-3-fluoro-1H-indazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1211537-09-5 SDS

1211537-09-5Downstream Products

1211537-09-5Relevant articles and documents

BENZOPYRAZOLE COMPOUND USED AS RHO KINASE INHIBITOR

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Paragraph 0326-0329, (2021/02/25)

The invention relates to a benzopyrazole compound used as RHO kinase inhibitor, a pharmaceutical composition and uses thereof for preparing an RHO kinase inhibiting drug, and more specifically to said compound of formula (I-1), a pharmaceutically acceptable salt and isomer thereof.

SALTS OF INDAZOLE DERIVATIVE AND CRYSTALS THEREOF

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Paragraph 0058, (2019/12/15)

The present invention provides salts of (E)-N-methyl-4-((2-(4-((E)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenylbut-1-en-1-yl)phenoxy)ethyl)amino)but-2-enamide represented by the formula I and acids, and crystals thereof, possessing a potential to

SALTS OF INDAZOLE DERIVATIVE AND CRYSTALS THEREOF

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Paragraph 0059, (2018/06/12)

The present invention provides salts of (E)-N,N-dimethyl-4-((2-((5-((Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenylbut-1-en-1-yl)pyridin-2-yl)oxy)ethyl)amino)but-2-enamide represented by the formula I and acids, and crystals thereof, possessing a potential to be used as drug substance in pharmaceuticals.

TETRASUBSTITUTED ALKENE COMPOUNDS AND THEIR USE

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Paragraph 0194; 0195, (2018/06/04)

Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-α protein.

TETRASUBSTITUTED ALKENE COMPOUNDS AND THEIR USE

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Paragraph 0262; 0263, (2016/12/22)

Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-α protein.

ESTROGEN RECEPTOR MODULATORS AND USES THEREOF

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Paragraph 00484, (2013/10/08)

Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

ESTROGEN RECEPTOR MODULATORS AND USES THEREOF

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Page/Page column 58-59, (2012/04/04)

Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

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