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CAS

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1314378-14-7

Fmoc-PEG4-NHS ester is a PEG linker containing an Fmoc-protected amine and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

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  • 1314378-14-7 Structure

  • Basic information

    1. Product Name: Fmoc-PEG4-NHS ester
    2. Synonyms: Fmoc-PEG4-NHS ester;Fmoc-NH-PEG4-NHS;Fmoc-N-amido-PEG4-NHS ester
    3. CAS NO:1314378-14-7
    4. Molecular Formula: C30H38N2O10
    5. Molecular Weight: 586.63012
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1314378-14-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: -20°C
    8. Solubility: Soluble in DMSO, DMF, DCM
    9. CAS DataBase Reference: Fmoc-PEG4-NHS ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: Fmoc-PEG4-NHS ester(1314378-14-7)
    11. EPA Substance Registry System: Fmoc-PEG4-NHS ester(1314378-14-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1314378-14-7(Hazardous Substances Data)

1314378-14-7 Usage

Uses

Used in Bioconjugation:
Fmoc-PEG4-NHS ester is used as a PEG linker for attaching various functional groups to proteins, peptides, and other biomolecules. The Fmoc-protected amine allows for selective deprotection and subsequent conjugation, while the NHS ester enables efficient coupling to primary amines.
Used in Drug Delivery Systems:
Fmoc-PEG4-NHS ester is used as a PEGylated drug carrier for improving the solubility, stability, and bioavailability of therapeutic agents. The hydrophilic PEG spacer enhances the water solubility of hydrophobic drugs, while the NHS ester allows for covalent attachment of drug molecules to the PEG linker.
Used in Diagnostic Imaging:
Fmoc-PEG4-NHS ester is used as a PEGylated contrast agent for enhancing the imaging contrast in various diagnostic techniques, such as magnetic resonance imaging (MRI) and fluorescence imaging. The PEG spacer improves the solubility and circulation time of the contrast agents in biological systems.
Used in Biomedical Research:
Fmoc-PEG4-NHS ester is used as a PEGylated probe for studying the interactions between biomolecules and their cellular targets. The PEG spacer provides a flexible and hydrophilic environment for the conjugated probes, facilitating their interaction with target molecules and improving the overall efficiency of the assays.

Check Digit Verification of cas no

The CAS Registry Mumber 1314378-14-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,1,4,3,7 and 8 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1314378-14:
(9*1)+(8*3)+(7*1)+(6*4)+(5*3)+(4*7)+(3*8)+(2*1)+(1*4)=137
137 % 10 = 7
So 1314378-14-7 is a valid CAS Registry Number.

1314378-14-7Upstream product

1314378-14-7Downstream Products

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