Fmoc-PEG8-NHS ester is a PEG linker that contains an Fmoc-protected amine and an NHS ester. The hydrophilic PEG spacer enhances solubility in aqueous media, while the Fmoc group can be deprotected under basic conditions to reveal the free amine for further conjugations. The NHS ester allows for the labeling of primary amines (-NH2) present in proteins, amine-modified oligonucleotides, and other amine-containing molecules.
1334170-03-4
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Basic information
- Product Name: Fmoc-PEG8-NHS ester
- Synonyms: Fmoc-PEG8-NHS ester;Fmoc-NH-PEG8-NHS
- CAS NO:1334170-03-4
- Molecular Formula: C38H58N2O14
- Molecular Weight: 766.87212
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1334170-03-4.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: 1.28±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: -20°C
- Solubility: Soluble in DMSO, DCM, DMF
- PKA: 11.60±0.46(Predicted)
- CAS DataBase Reference: Fmoc-PEG8-NHS ester(CAS DataBase Reference)
- NIST Chemistry Reference: Fmoc-PEG8-NHS ester(1334170-03-4)
- EPA Substance Registry System: Fmoc-PEG8-NHS ester(1334170-03-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1334170-03-4(Hazardous Substances Data)
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1334170-03-4 Usage
Uses
Used in Bioconjugation:Fmoc-PEG8-NHS ester is used as a PEG linker for bioconjugation purposes to improve the solubility and stability of biomolecules. The Fmoc-protected amine allows for selective deprotection and subsequent conjugation to other molecules, while the NHS ester enables the labeling of primary amines.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Fmoc-PEG8-NHS ester is used as a component in drug delivery systems to enhance the solubility and bioavailability of drugs. The PEG spacer can improve the pharmacokinetic properties of drug molecules, and the NHS ester allows for the attachment of drug molecules to targeting ligands or other functional groups.
Used in Diagnostics:
In the diagnostics industry, Fmoc-PEG8-NHS ester is used as a labeling agent for the detection and imaging of biological molecules. The NHS ester can be used to attach fluorescent tags, radiolabels, or other reporter groups to proteins, peptides, or oligonucleotides for various diagnostic assays.
Used in Research and Development:
In the research and development sector, Fmoc-PEG8-NHS ester is used as a versatile tool for the synthesis and modification of biologically active molecules. The PEG spacer and NHS ester provide a convenient means for attaching various functional groups to molecules of interest, facilitating the study of their properties and potential applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1334170-03-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,4,1,7 and 0 respectively; the second part has 2 digits, 0 and 3 respectively.Calculate Digit Verification of CAS Registry Number 1334170-03:
(9*1)+(8*3)+(7*3)+(6*4)+(5*1)+(4*7)+(3*0)+(2*0)+(1*3)=114
114 % 10 = 4
So 1334170-03-4 is a valid CAS Registry Number.
1334170-03-4Upstream product
1334170-03-4Downstream Products
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Fmoc-PEG8-NHS ester
