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1H-Indole-2,3-dione, 6-fluoro-1-methylis a chemical compound with the molecular formula C10H7NO2F. It is a derivative of indole, a heterocyclic aromatic organic compound. This specific compound contains a 6-fluoro and 1-methyl substituent on the indole ring. It is used in pharmaceutical research and may have potential applications as an antifungal or antibacterial agent. 1H-Indole-2,3-dione, 6-fluoro-1-methyl-’s structure and properties make it an important target for medicinal chemistry and drug discovery efforts.

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  • 134640-74-7 Structure
  • Basic information

    1. Product Name: 1H-Indole-2,3-dione, 6-fluoro-1-methyl-
    2. Synonyms:
    3. CAS NO:134640-74-7
    4. Molecular Formula: C9H6FNO2
    5. Molecular Weight: 179.151
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 134640-74-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1H-Indole-2,3-dione, 6-fluoro-1-methyl-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1H-Indole-2,3-dione, 6-fluoro-1-methyl-(134640-74-7)
    11. EPA Substance Registry System: 1H-Indole-2,3-dione, 6-fluoro-1-methyl-(134640-74-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 134640-74-7(Hazardous Substances Data)

134640-74-7 Usage

Uses

Used in Pharmaceutical Research:
1H-Indole-2,3-dione, 6-fluoro-1-methylis used as a research compound for exploring its potential as an antifungal or antibacterial agent. Its unique structure and properties make it a valuable target for medicinal chemistry and drug discovery efforts.
Used in Antifungal Applications:
1H-Indole-2,3-dione, 6-fluoro-1-methylis used as an antifungal agent for its potential to inhibit the growth of fungi. Its specific structure and properties may contribute to its effectiveness in treating fungal infections.
Used in Antibacterial Applications:
1H-Indole-2,3-dione, 6-fluoro-1-methylis used as an antibacterial agent for its potential to inhibit the growth of bacteria. Its unique chemical structure may provide a new approach to combating bacterial infections, particularly in cases of antibiotic resistance.

Check Digit Verification of cas no

The CAS Registry Mumber 134640-74-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,6,4 and 0 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 134640-74:
(8*1)+(7*3)+(6*4)+(5*6)+(4*4)+(3*0)+(2*7)+(1*4)=117
117 % 10 = 7
So 134640-74-7 is a valid CAS Registry Number.

134640-74-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-fluoro-1-methylindole-2,3-dione

1.2 Other means of identification

Product number -
Other names 6-fluoro-1-methyl-2,3-dihydro-1H-indole-2,3-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:134640-74-7 SDS

134640-74-7Downstream Products

134640-74-7Relevant articles and documents

Metal-free synthesis of benzimidazo[1,2-c]quinazolin-6-ones with indole and benzenediamine oxidized by I2/TBHP

Dai, Zhen,Li, Songhua,Li, Yunyi,Feng, Lei,Ma, Chen

, p. 2012 - 2017 (2019/02/20)

A variety of benzimidazo[1,2-c]quinazolin-6-ones derivatives can be accessed in moderate to good yields under simple and metal-free reaction conditions using indoles and o-benzenediamines oxidized by iodine and TBHP. This procedure works in reasonable yields for different indoles as well as o-benzenediamines thus may provide a good synthesis of quinazolinones. A TBHP oxidized ring expansion reaction mechanism that explains the synthesis of benzimidazo[1,2-c]quinazolin-6-ones were reported.

PYRIDINONE DERIVATIVES AND THEIR USE AS SELECTIVE ALK-2 INHIBITORS

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Page/Page column 45-46; 74, (2019/06/11)

The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Organocatalytic double arylation of 3-isothiocyanato oxindoles: Stereocontrolled synthesis of complex spirooxindoles

Zhang, Lin-Lin,Da, Bing-Chao,Xiang, Shao-Hua,Zhu, Shuai,Yuan, Zi-Yun,Guo, Zhen,Tan, Bin

supporting information, p. 1689 - 1696 (2018/11/25)

Quinones, precursors of aromatic structures, were firstly employed as the electrophiles for the organocatalytic Michael addition/cyclization cascade reaction with versatile 3-isothiocyanato oxindoles. Chiral bifunctional organocatalyst was appropriate for this enantioselective transformation to afford a variety of novel spirooxindoles, possessing a spirocyclic stereocenter adjacent to the aromatic ring, via asymmetric double arylation. These synthesized spirooxindoles are very difficult to access by the reported methods and were obtained in excellent chemical yields with excellent enantioselectivities.

ISOXAZOLYL-CARBONYLOXY AZABICYCLO[3.2.1]OCTANYL COMPOUNDS AS FXR ACTIVATORS

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Paragraph 00470, (2018/09/25)

The disclosure relates to activators of FXR useful in the treatment of autoimmune disorders, liver disease, intestinal disease, kidney disease, cancer, and other diseases in which FXR plays a role, having the Formula (I): wherein L1, L2, A, B, R1, R2, R3, and R4 are described herein.

BROMODOMAIN INHIBITORS

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Page/Page column 67, (2018/11/22)

Compounds of formula (I), wherein R 1, R 2, R 3, R 5, R 6, R 7, A 1, A 2, A 3, A 4, X 1, and X 2 have any of the values defined in the specification and pharmaceutically acceptable salts thereof, which are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS are provided. Pharmaceutical compositions comprising of compounds of formula (I) are also provided.

Iodine-Catalyzed Oxidation of N-Substituted Indoles by using Chloramine-B: A Facile and Practical Approach to Isatins

Liu, Peijun,Guo, Jiajing,Wei, Wentao,Liu, Xiaozu,Sun, Pinghua

supporting information, p. 2105 - 2109 (2016/05/09)

An efficient method for the iodine-catalyzed oxidation of N-substituted indoles by using chloramine-B under mild reaction conditions was explored. This reaction was found to be tolerant to a variety of functional groups and provided the corresponding isatins in moderate to excellent yields. In addition, application of this method to the one-pot synthesis of 3-hydroxyoxindole and N-methylisatin oxime was realized.

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