t-Boc-N-amido-PEG5-acid is a PEG (polyethylene glycol) linker that features a terminal carboxylic acid and a Boc-protected amino group. This molecule is designed to enhance solubility in aqueous media due to the hydrophilic PEG spacer. The terminal carboxylic acid is capable of reacting with primary amine groups in the presence of activators, such as EDC or HATU, to form a stable amide bond. Additionally, the Boc group can be removed under mild acidic conditions, revealing the free amine.
1347750-78-0 Suppliers
Post Buying RequestRecommended suppliersmore
-
-
Basic information
- Product Name: t-Boc-N-amido-PEG5-acid
- Synonyms: Boc-N-amido-PEG5-acid;t-boc-N-amido-PEG5-propionic acid;BOC-PEG5-CH2CH2COOH
- CAS NO:1347750-78-0
- Molecular Formula: C18H35NO9
- Molecular Weight: 409.4718
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1347750-78-0.mol
-
Chemical Properties
- Melting Point: N/A
- Boiling Point: 536.9±50.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.123±0.06 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: N/A
- PKA: 4.28±0.10(Predicted)
- CAS DataBase Reference: t-Boc-N-amido-PEG5-acid(CAS DataBase Reference)
- NIST Chemistry Reference: t-Boc-N-amido-PEG5-acid(1347750-78-0)
- EPA Substance Registry System: t-Boc-N-amido-PEG5-acid(1347750-78-0)
-
Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1347750-78-0(Hazardous Substances Data)
1347750-78-0 Usage
Uses
Used in Bioconjugation:t-Boc-N-amido-PEG5-acid is used as a bioconjugation agent for the formation of stable amide bonds between molecules. The application reason is its ability to react with primary amine groups in the presence of activators, creating a stable linkage that can be useful in various biological and pharmaceutical applications.
Used in Drug Delivery Systems:
In the pharmaceutical industry, t-Boc-N-amido-PEG5-acid is used as a component in drug delivery systems for improving the solubility and bioavailability of drugs. The reason for its application is the hydrophilic PEG spacer, which increases the solubility of the drug in aqueous media and can potentially enhance the drug's therapeutic efficacy.
Used in Protein Modification:
t-Boc-N-amido-PEG5-acid is used as a protein modification agent to introduce PEGylation, a process that can improve the stability, solubility, and half-life of proteins in biological systems. The application reason is the ability to form stable amide bonds with primary amine groups on the protein, as well as the Boc group's deprotection under mild acidic conditions to reveal the free amine.
Used in Chemical Synthesis:
In the field of chemical synthesis, t-Boc-N-amido-PEG5-acid is used as an intermediate for the synthesis of various PEGylated compounds. The application reason is its versatile reactivity, allowing for the formation of stable amide bonds and the deprotection of the Boc group to access free amines for further reactions.
Check Digit Verification of cas no
The CAS Registry Mumber 1347750-78-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,7,7,5 and 0 respectively; the second part has 2 digits, 7 and 8 respectively.Calculate Digit Verification of CAS Registry Number 1347750-78:
(9*1)+(8*3)+(7*4)+(6*7)+(5*7)+(4*5)+(3*0)+(2*7)+(1*8)=180
180 % 10 = 0
So 1347750-78-0 is a valid CAS Registry Number.
1347750-78-0Upstream product
1347750-78-0Downstream Products
Post a RFQ
1
What can I do for you?
Get Best Price
Get Best Price for 1347750-78-0
t-Boc-N-amido-PEG5-acid
